Reactome | SPSB2 [cytosol]

SPSB2 [cytosol]

Stable Identifier

R-HSA-976048

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SPRY domain-containing SOCS box protein 2, SPSB2_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB2 [cytosol] (Homo sapiens)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB2 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB2 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB2 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB2 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB2 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB2 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB2 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB2 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99619 SPSB2

Gene Names

SPSB2, GRCC9, SSB2

Chain

chain:1-263

Reference Genes

BioGPS Gene:84727 SPSB2

COSMIC (genes):SPSB2 SPSB2

CTD Gene:84727 SPSB2

dbSNP Gene:84727 SPSB2

ENSEMBL:ENSG00000111671 SPSB2

HGNC:29522 SPSB2

KEGG:hsa:84727 SPSB2

Monarch:84727 SPSB2

NCBI Gene:84727 SPSB2

OMIM:611658 SPSB2

UCSC:Q99619 SPSB2

Reference Transcript

Other Identifiers

105369632

11728534_a_at

11747431_at

11757357_x_at

16760636

223580_PM_at

223580_at

3442346

3442347

3442348

3442349

3442350

3442351

3442352

3442353

3442355

3442356

3442357

3442358

3442359

3442360

3442361

3442364

7960709

84727

A_23_P151098

A_33_P3218188

GE88591

GO:0005515

GO:0005737

GO:0005829

GO:0006511

GO:0016567

GO:0019005

GO:0030163

GO:0035556

GO:0043161

GO:0060090

GO:1990756

HMNXSV003026694

HMNXSV003048994

ILMN_1787541

PH_hs_0022196

g12804248_3p_at

g12804248_3p_x_at

Participates

as a member of

CUL5-box protein [cytosol] (Homo sapiens)

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

Homologues of SPSB2 [cytosol] (Caenorhabditis elegans)

Homologues of SPSB2 [cytosol] (Danio rerio)

spsb-1 [cytosol] (Caenorhabditis elegans)

spsb4 [cytosol] (Xenopus tropicalis)

spsb-2 [cytosol] (Caenorhabditis elegans)

spsb4a [cytosol] (Danio rerio)

SPSB4 [cytosol] (Gallus gallus)

SPSB2 [cytosol] (Bos taurus)

SPSB2 [cytosol] (Canis familiaris)

SPSB2 [cytosol] (Dictyostelium discoideum)

SPSB2 [cytosol] (Sus scrofa)

gus [cytosol] (Drosophila melanogaster)

spsb4b [cytosol] (Danio rerio)

Spsb2 [cytosol] (Mus musculus)

Spsb2 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001139788.1, NP_116030.1, NP_001306599.1

ENSEMBL

ENSP00000430872, ENSP00000431037, ENST00000524270, ENSP00000428338, ENST00000519357, ENST00000523102

OpenTargets

ENSG00000111671

HPA

ENSG00000111671-SPSB2

ZINC - Substances

SPSB2_HUMAN

ZINC target

Q99619

PRO

Q99619

Pharos - Targets

Q99619

ZINC - Predictions - Purchasable

SPSB2_HUMAN

PDB

6JWN, 6JWM, 6DN6, 3EMW, 5XN3, 6KEY, 6DN5, 6JKJ

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15369 ELOC	2	TCEB1 [nucleoplasm] (R-HSA-112422) ELOC [cytosol] (R-HSA-180535)	0.669	4
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.643	5
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.556	3
UniProt:P16284 PECAM1	5	PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:Q15370 ELOB	2	TCEB2 [nucleoplasm] (R-HSA-112423) ELOB [cytosol] (R-HSA-180551)	0.527	3
UniProt:Q9UBF6 RNF7	1	RNF7 (RBX2) [cytosol] (R-HSA-8863132)	0.527	3
UniProt:Q99873 PRMT1	2	PRMT1 [nucleoplasm] (R-HSA-3215140) PRMT1 [cytosol] (R-HSA-9632173)	0.508	2