Reactome | SMARCD1 [nucleoplasm]

SMARCD1 [nucleoplasm]

Stable Identifier

R-HSA-389255

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

BAF60a

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
        
        RUNX1 binds the SWI/SNF complex (Homo sapiens)
        
        RUNX1:CBFB:SWI/SNF [nucleoplasm] (Homo sapiens)
        
        SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
        
        SWI/SNF additional components [nucleoplasm] (Homo sapiens)
        
        SMARCD1 [nucleoplasm] (Homo sapiens)
        
        SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
        
        SWI/SNF additional components [nucleoplasm] (Homo sapiens)
        
        SMARCD1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96GM5 SMARCD1

Gene Names

SMARCD1, BAF60A

Chain

chain:1-515

Reference Genes

BioGPS Gene:6602 SMARCD1

COSMIC (genes):SMARCD1 SMARCD1

CTD Gene:6602 SMARCD1

dbSNP Gene:6602 SMARCD1

ENSEMBL:ENSG00000066117 SMARCD1

ENSEMBL:ENSG00000066117.15 SMARCD1

HGNC:11106 SMARCD1

KEGG Gene (Homo sapiens):6602 SMARCD1

Monarch:6602 SMARCD1

NCBI Gene:6602 SMARCD1

OMIM:601735 SMARCD1

UCSC:Q96GM5 SMARCD1

Reference Transcript

Other Identifiers

11741620_a_at

11751008_a_at

11755827_a_at

16751020

203183_PM_s_at

203183_s_at

209518_PM_at

209518_at

3414391

3414392

3414393

3414394

3414395

3414396

3414397

3414398

3414399

3414400

3414401

3414402

3414403

3414404

3414406

3414407

3414409

3414411

3414412

3414413

3414414

3414415

3414416

3414417

3414418

37753_at

454_at

6602

7955331

A_23_P204745

A_24_P232696

GE59341

GO:0000278

GO:0000776

GO:0000785

GO:0002376

GO:0003682

GO:0003712

GO:0003713

GO:0005102

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006281

GO:0006325

GO:0006337

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0007059

GO:0007155

GO:0007399

GO:0008284

GO:0016363

GO:0016514

GO:0016586

GO:0030071

GO:0030154

GO:0035060

GO:0043226

GO:0043231

GO:0045582

GO:0045596

GO:0045597

GO:0045663

GO:0045815

GO:0045893

GO:0048856

GO:0060090

GO:0070316

GO:0071398

GO:0071564

GO:0071565

GO:0140014

GO:0140110

GO:0140288

GO:1902459

GO:2000045

GO:2000781

GO:2000819

HMNXSV003050983

Hs.79335.1.S2_3p_at

ILMN_1727173

ILMN_1728845

PH_hs_0004588

TC12000387.hg

U66617_at

g4507082_3p_a_at

Participates

as a candidate of

SWI/SNF additional components [nucleoplasm] (Homo sapiens)

Inferred To

SNF12 [nucleoplasm] (Saccharomyces cerevisiae)

SMARCD1 [nucleoplasm] (Bos taurus)

SMARCD1 [nucleoplasm] (Canis familiaris)

SMARCD1 [nucleoplasm] (Gallus gallus)

SMARCD1 [nucleoplasm] (Sus scrofa)

snf12-1 [nucleoplasm] (Dictyostelium discoideum)

asic1 [nucleoplasm] (Xenopus tropicalis)

ham-3 [nucleoplasm] (Caenorhabditis elegans)

ssr3 [nucleoplasm] (Schizosaccharomyces pombe)

Bap60 [nucleoplasm] (Drosophila melanogaster)

wu:fa10h07 [nucleoplasm] (Danio rerio)

Smarcd1 [nucleoplasm] (Mus musculus)

Smarcd1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_620710.2, NP_003067.3

OpenTargets

ENSG00000066117

HPA

ENSG00000066117-SMARCD1

GeneCards

Q96GM5

Ensembl

ENSP00000370924, ENSP00000378414, ENSG00000066117, ENST00000394963, ENST00000381513

PRO

Q96GM5

Pharos - Targets

Q96GM5

Orphanet

26514

PDB

6LTJ, 6LTH, 7VDV, 7Y8R

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.784	9
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.718	6
UniProt:Q14145 KEAP1	3	Ub-KEAP1 [cytosol] (R-HSA-6782766) ub-KEAP1 [cytosol] (R-HSA-9766647) KEAP1 [cytosol] (R-HSA-976038)	0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q6ZMU5 TRIM72	1	TRIM72 [cytoplasmic vesicle membrane] (R-HSA-5263653)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	12
UniProt:Q96CV9 OPTN	5	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907)	0.556	3
UniProt:Q00994 BEX3	1	NGFRAP1 [cytosol] (R-HSA-194333)	0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:P08123 COL1A2	20	GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023602) 3x4Hyp-3Hyp-GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023558) GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023547) 3x4Hyp-GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023674) 3x4Hyp-GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023580) 3x4Hyp-3Hyp-GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023663) 3x4Hyp-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022070) 3x4Hyp-3Hyp-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022501) 3x4Hyp-5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022977) 3x4Hyp-3Hyp-5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022966) 5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022455) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396490) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396080) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396375) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396493) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396241) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396064) Dehydrolysinonorlysyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396361) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396431) Dehydrolysinonorlysyl 4-Hyp Glu-Gal-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396174)	0.556	3
UniProt:Q9H3P2 NELFA	1	NELFA [nucleoplasm] (R-HSA-112426)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q9BRX5 GINS3	1	GINS3 [nucleoplasm] (R-HSA-5688046)	0.556	3
UniProt:P31249 HOXD3	1	HOXD3 [nucleoplasm] (R-HSA-5617674)	0.556	3
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3

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