Reactome | CFH [extracellular region]

CFH [extracellular region]

Stable Identifier

R-HSA-976788

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Complement factor H, CFAH_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P08603 CFH

Gene Names

CFH, HF, HF1, HF2

Chain

signal peptide:1-18, chain:19-1231

Reference Genes

COSMIC (genes):CFH CFH

dbSNP Gene:3075 CFH

ENSEMBL:ENSG00000000971 CFH

Participates

as an output of

Factor I inactivates plasma Factor H-bound C3b (Homo sapiens)

as a component of

as an input of

as a member of

CFH, CFHR3 [extracellular region] (Homo sapiens)

Inferred To

cfh [extracellular region] (Danio rerio)

svep1l [extracellular region] (Xenopus tropicalis)

Homologues of CFH [extracellular region] (Bos taurus)

Homologues of CFH [extracellular region] (Danio rerio)

Homologues of CFH [extracellular region] (Xenopus tropicalis)

f13b [extracellular region] (Xenopus tropicalis)

LOC100336868 [extracellular region] (Bos taurus)

cfhl2 [extracellular region] (Danio rerio)

CFH [extracellular region] (Bos taurus)

CFH [extracellular region] (Canis familiaris)

CFH [extracellular region] (Gallus gallus)

CFH [extracellular region] (Sus scrofa)

cfhl1 [extracellular region] (Danio rerio)

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02741 CRP	1	CRP(19-224) [extracellular region] (R-HSA-976719)	0.976	39
IntAct:EBI-12735745 C3B			0.957	13
UniProt:P01024-PRO_0000005911 C3			0.869	10
UniProt:P26022-PRO_0000023545 PTX3			0.756	8
UniProt:P01024 C3	20	C3d fragment [extracellular region] (R-HSA-198999) C3 alpha chain [azurophil granule lumen] (R-HSA-6799161) C3 beta chain [azurophil granule lumen] (R-HSA-6799159) C3 alpha chain [secretory granule lumen] (R-HSA-6800982) C3 beta chain [secretory granule lumen] (R-HSA-6801014) p-C3 [endoplasmic reticulum lumen] (R-HSA-8957056) C3 [endoplasmic reticulum lumen] (R-HSA-8956774) C3c alpha' chain fragment 1 precursor [extracellular region] (R-HSA-976816) C3c alpha' chain fragment 2 [extracellular region] (R-HSA-976818) C3c alpha' chain fragment 1 [extracellular region] (R-HSA-3266502) C3a-desArg [extracellular region] (R-HSA-8852808) C3dg [plasma membrane] (R-HSA-3266505) C3d [plasma membrane] (R-HSA-8853248) C3f [extracellular region] (R-HSA-976779) C3 beta chain [plasma membrane] (R-HSA-977593) C3c alpha' chain fragment 1 precursor [plasma membrane] (R-HSA-977595) C3c alpha' chain fragment 2 [plasma membrane] (R-HSA-977594) C3 alpha chain [extracellular region] (R-HSA-166820) C3b alpha' [extracellular region] (R-HSA-166830) C3 beta chain [extracellular region] (R-HSA-166821)	0.743	6
UniProt:P26022 PTX3	3	PTX3 [tertiary granule lumen] (R-HSA-6800932) PTX3 [extracellular region] (R-HSA-6806290) PTX3 [specific granule lumen] (R-HSA-6799620)	0.734	15
UniProt:P05156 CFI	2	CFI(340-583) [extracellular region] (R-HSA-976750) CFI(19-335) [extracellular region] (R-HSA-976782)	0.73	6
UniProt:P08603 CFH	1	CFH [extracellular region] (R-HSA-976788)	0.713	5
UniProt:A0A024A2C9 A0A024A2C9			0.71	6
ChEBI:28304 HEPARIN			0.702	5
UniProt:P01024-PRO_0000005908 C3			0.676	4
UniProt:P02649 APOE	10	APOE [endoplasmic reticulum lumen] (R-HSA-6784908) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [extracellular region] (R-HSA-174646) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE-4 [extracellular region] (R-HSA-9711070) APOE [plasma membrane] (R-HSA-174615) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [endosome membrane] (R-HSA-174766) APOE [endosome lumen] (R-HSA-174804) APOE [early endosome] (R-HSA-2429687)	0.672	8
UniProt:P02769 ALB	1	Serum albumin [extracellular region] (R-BTA-879495)	0.672	10
UniProt:Q9JXV4 FHBP			0.655	6
UniProt:Q932F7 SDRE			0.655	4
UniProt:Q03591 CFHR1	1	CFHR1 [extracellular region] (R-HSA-8851432)	0.636	3
UniProt:P13605	11	FMOD [Golgi lumen] (R-BTA-2046263) FMOD [Golgi lumen] (R-BTA-2046193) FMOD [Golgi lumen] (R-BTA-2046217) FMOD [Golgi lumen] (R-BTA-2046236) FMOD [Golgi lumen] (R-BTA-2046308) FMOD [Golgi lumen] (R-BTA-2046208) FMOD [Golgi lumen] (R-BTA-2046229) FMOD [Golgi lumen] (R-BTA-2046259) FMOD [extracellular region] (R-BTA-2046223) FMOD [lysosomal lumen] (R-BTA-2105016) FMOD [lysosomal lumen] (R-BTA-2046247)	0.618	4
UniProt:HIB_11110 E1X6C6			0.611	4
phosphocholine [ChEBI:18132]	3	ChoP [extracellular region] (R-ALL-6814794) ChoP [endoplasmic reticulum lumen] (R-ALL-1606280) ChoP [cytosol] (R-ALL-194358)	0.609	2
UniProt:P05156-PRO_0000027569 CFI			0.544	2
UniProt:P05156-PRO_0000027570 CFI			0.544	2
ChEBI:39026 LOW-DENSITY LIPOPROTEIN			0.524	5

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