Reactome | KLC2 [cytosol]

KLC2 [cytosol]

Stable Identifier

R-HSA-983191

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Kinesin light chain 2, KLC2_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate KTN1 (Homo sapiens)
        
        KTN1 binds Kinesin-1 (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC2 [cytosol] (Homo sapiens)
        
        RHOA,RHOG,RAC1,CDC42:GTP:KTN1:Kinesin-1 [endoplasmic reticulum membrane] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC2 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC2 [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC2 [cytosol] (Homo sapiens)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC2 [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H0B6 KLC2

Gene Names

KLC2

Chain

chain:1-622

Reference Genes

BioGPS Gene:64837 KLC2

COSMIC (genes):KLC2 KLC2

CTD Gene:64837 KLC2

dbSNP Gene:64837 KLC2

ENSEMBL:ENSG00000174996.12 KLC2

HGNC:20716 KLC2

KEGG Gene (Homo sapiens):64837 KLC2

Monarch:64837 KLC2

NCBI Gene:64837 KLC2

OMIM:611729 KLC2

UCSC:Q9H0B6 KLC2

Reference Transcript

Other Identifiers

11741614_x_at

11755410_x_at

16727324

218906_PM_x_at

218906_x_at

3336044

3336045

3336048

3336049

3336056

3336057

3336058

3336059

3336060

3336061

3336062

3336063

3336064

3336065

3336066

3336067

3336068

3336069

3336071

3336072

3336073

3336075

54439_at

64837

7941565

A_24_P227211

A_33_P3219895

A_33_P3288805

GE88516

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005764

GO:0005765

GO:0005773

GO:0005829

GO:0005856

GO:0005871

GO:0005874

GO:0005886

GO:0007018

GO:0008092

GO:0016020

GO:0016938

GO:0019894

GO:0032418

GO:0032991

GO:0043226

GO:0045296

HMNXSV003032784

ILMN_1774493

ILMN_1779064

PH_hs_0014454

TC11000656.hg

Participates

as a member of

KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)

Inferred To

klc-1 [cytosol] (Caenorhabditis elegans)

Klc2 [cytosol] (Mus musculus)

Klc2 [cytosol] (Rattus norvegicus)

klc-2 [cytosol] (Caenorhabditis elegans)

Homologues of KLC2 [cytosol] (Caenorhabditis elegans)

Klc [cytosol] (Drosophila melanogaster)

KLC2 [cytosol] (Bos taurus)

KLC2 [cytosol] (Canis familiaris)

KLC2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001128248.1, XP_005274240.1, NP_073733.1, NP_001128247.1, NP_001128246.1, NP_001305663.1

OpenTargets

ENSG00000174996

HPA

ENSG00000174996-KLC2

GeneCards

Q9H0B6

Ensembl

ENST00000394066, ENSP00000399403, ENSP00000377630, ENSG00000174996, ENST00000316924, ENSP00000377631, ENSP00000408484, ENST00000417856, ENST00000394067, ENSP00000314837, ENST00000421552

PRO

Q9H0B6

Pharos - Targets

Q9H0B6

Orphanet

23633

PDB

3EDT, 3CEQ

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.688	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.601	4