Reactome | ICOS [plasma membrane]

Stable Identifier

R-HSA-9845023

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Inducible T-cell costimulator, ICOS_HUMAN

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Disease (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y6W8 ICOS

Gene Names

ICOS, AILIM

Chain

signal peptide:1-20, chain:21-199

Reference Genes

ENSEMBL:ENSG00000163600 ICOS

Participates

as a component of

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75144 ICOSLG	1	ICOSLG [plasma membrane] (R-HSA-197910)	0.733	8
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.623	5
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397)	0.499	5

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