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phospho-p-S177,S181-IKBKB [cytosol]
Stable Identifier
R-MMU-202506
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
O88351
Locations in the PathwayBrowser for interactor UniProt:Q14145 KEAP1
Expand all
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
IKBA is phosphorylated by Phospho IKKB kinase (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:O88351
Reference Genes
BioGPS Gene:16150
ENSEMBL:ENSMUSG00000031537
KEGG:mmu:16150
Monarch:16150
NCBI Gene:16150
UCSC:O88351
Reference Transcript
RefSeq:NM_010546.2
Participates
as a component of
Phospho-IKK-beta homdimer [cytosol] (Mus musculus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
Other forms of this molecule
IKBKB [cytosol]
Inferred From
p-S177,S181-IKBKB [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 177 (in Homo sapiens)
Coordinate
177
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 181 (in Homo sapiens)
Coordinate
181
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_034676.1
ZINC - Substances
IKKB_MOUSE
ZINC target
O88351
PRO
O88351
GlyGen
O88351
MGI
1338071
ZINC - Predictions - Purchasable
IKKB_MOUSE
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O88522
5
IKBKG [cytosol]
(R-MMU-168108)
Ub-285-IKBKG [cytosol]
(R-MMU-741397)
K63polyUb-IKBKG [cytosol]
(R-MMU-202530)
IKBKG [nucleoplasm]
(R-MMU-4755413)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-MMU-4755449)
0.896
8
UniProt:Q60680
4
phospho-p-Y187,Y198-CHUK [cytosol]
(R-MMU-9861501)
phospho-p-T23-CHUK [cytosol]
(R-MMU-198615)
phospho-p-S176,S180-CHUK [cytosol]
(R-MMU-177667)
CHUK [cytosol]
(R-MMU-168104)
0.656
4
UniProt:Q14145 KEAP1
3
KEAP1 [cytosol]
(R-HSA-976038)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
0.508
2
UniProt:P01375 TNF
5
TNF(1-233) [plasma membrane]
(R-HSA-66220)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
0.499
3
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