Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
THBS1 [platelet alpha granule lumen]
Stable Identifier
R-HSA-114701
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
platelet alpha granule lumen
Synonyms
Thrombospondin 1 precursor
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
THBS1 trimer [platelet alpha granule lumen] (Homo sapiens)
THBS1 [platelet alpha granule lumen] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)
THBS1 trimer [platelet alpha granule lumen] (Homo sapiens)
THBS1 [platelet alpha granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07996 THBS1
Gene Names
THBS1, TSP, TSP1
Chain
signal peptide:1-18, chain:19-1170
Reference Genes
BioGPS Gene:7057 THBS1
COSMIC (genes):THBS1 THBS1
CTD Gene:7057 THBS1
dbSNP Gene:7057 THBS1
ENSEMBL:ENSG00000137801 THBS1
HGNC:11785 THBS1
KEGG Gene (Homo sapiens):7057 THBS1
Monarch:7057 THBS1
NCBI Gene:7057 THBS1
OMIM:188060 THBS1
UCSC:P07996 THBS1
Reference Transcript
RefSeq:NM_003246.3 THBS1
Other Identifiers
0004480278
115_at
11721090_at
11721091_a_at
11721092_a_at
11721093_a_at
11758842_at
16799315
1LSL
1UX6
1Z78
1ZA4
201107_s_at
201108_s_at
201109_s_at
201110_s_at
235086_at
2ERF
2ES3
2OUH
2OUJ
33678
3589467
3589468
3589469
3589470
3589472
3589473
3589474
3589475
3589479
3589482
3589484
3589486
3589487
3589489
3589491
3589493
3589495
3589497
3589498
3589500
3589501
3589504
3589505
3589509
3589510
3589511
3589512
3589513
3589514
3589515
3589516
3R6B
53546_at
59756
5FOE
7057
7982597
867_s_at
A8MZG1
A_14_P135563
A_23_P206212
A_33_P3415820
AAA36741
AAA61178
AAA61237
AAB59366
AAI36470
AAI36471
AB209912
AC037198
AK291639
AK304754
BAD93149
BAF84328
BAG65509
BC136469
BC136470
CAA28370
CAA32889
CAB033678
CCDS32194
ENSG00000137801
ENSP00000260356
ENST00000260356
ENST00000260356.5
EntrezGene:7057
EntrezGene:THBS1
g4507484_3p_a_at
GE81252
GE86195
GO:0000187
GO:0001666
GO:0001786
GO:0001937
GO:0001953
GO:0001968
GO:0002040
GO:0002376
GO:0002544
GO:0002576
GO:0002581
GO:0002605
GO:0003674
GO:0005178
GO:0005198
GO:0005201
GO:0005509
GO:0005515
GO:0005575
GO:0005576
GO:0005577
GO:0005615
GO:0005622
GO:0005623
GO:0005737
GO:0005783
GO:0005788
GO:0005886
GO:0006412
GO:0006464
GO:0006810
GO:0006950
GO:0006954
GO:0006955
GO:0006986
GO:0007049
GO:0007050
GO:0007155
GO:0007165
GO:0008150
GO:0008201
GO:0008219
GO:0008283
GO:0008284
GO:0008289
GO:0009058
GO:0009612
GO:0009749
GO:0009897
GO:0009986
GO:0010595
GO:0010596
GO:0010748
GO:0010751
GO:0010754
GO:0010757
GO:0010759
GO:0010763
GO:0016192
GO:0016477
GO:0016525
GO:0016529
GO:0017134
GO:0018149
GO:0022607
GO:0030141
GO:0030154
GO:0030169
GO:0030194
GO:0030198
GO:0030335
GO:0030511
GO:0031012
GO:0031091
GO:0031093
GO:0031410
GO:0032026
GO:0032570
GO:0032695
GO:0032914
GO:0032991
GO:0033574
GO:0034330
GO:0034605
GO:0034641
GO:0034976
GO:0040011
GO:0040037
GO:0042327
GO:0042493
GO:0042535
GO:0042802
GO:0043032
GO:0043066
GO:0043154
GO:0043167
GO:0043226
GO:0043236
GO:0043394
GO:0043536
GO:0043537
GO:0043652
GO:0045652
GO:0045727
GO:0045766
GO:0048266
GO:0048646
GO:0048661
GO:0048856
GO:0048870
GO:0050431
GO:0050840
GO:0050921
GO:0051592
GO:0051604
GO:0051895
GO:0051897
GO:0051918
GO:0055085
GO:0061024
GO:0062023
GO:0070051
GO:0070052
GO:0070062
GO:0071356
GO:0071363
GO:0071636
GO:0090051
GO:1902043
GO:1903588
GO:1903671
GO:2000353
GO:2000379
GO:2001027
GO:2001237
HGNC:11785
HPA059756
Hs.42699.0.A1_3p_at
Hs.87409.0.A1_3p_a_at
Hs.87409.0.A2_3p_a_at
Hs.87409.0.A3_3p_a_at
ILMN_1686116
IPR000742
IPR000884
IPR001007
IPR001791
IPR001881
IPR003367
IPR008859
IPR013032
IPR013320
IPR017897
IPR028499
IPR028974
IPR036383
J04835
M14326
M25631
M99425
MIM:188060
NM_003246
NP_003237
PF00090
PF00093
PF02412
PF05735
PH_hs_0022773
PR01705
SM00179
SM00181
SM00209
SM00210
SM00214
TC15000270.hg
THBS1
THBS1-201
UPI00001FE219
X04665
X14787
X14787_at
XM_011521971
XP_011520273
Participant Of
hasComponent
THBS1 trimer [platelet alpha granule lumen]
Other forms of this molecule
THBS1 [endoplasmic reticulum lumen]
glc-fuc-THBS1 [endoplasmic reticulum lumen]
O-fuc-THBS1 [endoplasmic reticulum lumen]
THBS1 [extracellular region]
Inferred To
THBS1 [platelet alpha granule lumen] (Canis familiaris)
THBS1 [platelet alpha granule lumen] (Danio rerio)
THBS1 [platelet alpha granule lumen] (Drosophila melanogaster)
THBS1 [platelet alpha granule lumen] (Gallus gallus)
THBS1 [platelet alpha granule lumen] (Mus musculus)
THBS1 [platelet alpha granule lumen] (Rattus norvegicus)
THBS1 [platelet alpha granule lumen] (Sus scrofa)
THBS1 [platelet alpha granule lumen] (Xenopus tropicalis)
Cross References
RefSeq
NP_003237.2
OpenTargets
ENSG00000137801
GeneCards
P07996
PRO
P07996
PDB
2ERF
,
1UX6
,
1LSL
,
2OUJ
,
2OUH
,
1Z78
,
5FOE
,
1ZA4
,
2ES3
,
3R6B
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02751 FN1
8
FN1(32-271) [extracellular region]
(R-HSA-3787935)
FN1(32-2386) [platelet alpha granule lumen]
(R-HSA-114620)
FN1(272-2386) [extracellular region]
(R-HSA-3788024)
FN1(32-?) [extracellular region]
(R-HSA-2533850)
FN1(?-2386) [extracellular region]
(R-HSA-2533841)
p-FN1 [endoplasmic reticulum lumen]
(R-HSA-8956937)
FN1 [endoplasmic reticulum lumen]
(R-HSA-8956708)
FN1(32-2386) [extracellular region]
(R-HSA-54851)
0.609
2
UniProt:Q15113 PCOLCE
1
PCOLCE [extracellular region]
(R-HSA-2002444)
0.558
3
UniProt:P01137 TGFB1
6
TGFB1 [Golgi lumen]
(R-HSA-177108)
TGFB1 [extracellular region]
(R-HSA-170838)
TGFB1(30-390) [Golgi lumen]
(R-HSA-114705)
TGFB1 [plasma membrane]
(R-HSA-5146781)
TGFB1(30-278) [extracellular region]
(R-HSA-2395367)
TGFB1(30-278) [platelet alpha granule lumen]
(R-HSA-65936)
0.525
2
UniProt:P08567 PLEK
2
PLEK [cytosol]
(R-HSA-350715)
PLEK [extracellular region]
(R-HSA-350741)
0.462
3
© 2019
Reactome