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ASAP1 [cytosol]
Stable Identifier
R-HSA-5620905
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
DDEF1
Locations in the PathwayBrowser
Expand all
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Cargo trafficking to the periciliary membrane (Homo sapiens)
VxPx cargo-targeting to cilium (Homo sapiens)
ASAP1 dimer binds membrane proteins (Homo sapiens)
ASAP1 dimer [cytosol] (Homo sapiens)
ASAP1 [cytosol] (Homo sapiens)
ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
ASAP1 dimer [cytosol] (Homo sapiens)
ASAP1 [cytosol] (Homo sapiens)
ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Homo sapiens)
ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
ASAP1 dimer [cytosol] (Homo sapiens)
ASAP1 [cytosol] (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
ASAP1 dimer [cytosol] (Homo sapiens)
ASAP1 [cytosol] (Homo sapiens)
ASAP1 stimulates GTPase activity of ARF4 (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
ASAP1 dimer [cytosol] (Homo sapiens)
ASAP1 [cytosol] (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
ASAP1 dimer [cytosol] (Homo sapiens)
ASAP1 [cytosol] (Homo sapiens)
Cargo-carrying vesicles bud from the TGN (Homo sapiens)
RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
ASAP1 dimer [cytosol] (Homo sapiens)
ASAP1 [cytosol] (Homo sapiens)
RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
ASAP1 dimer [cytosol] (Homo sapiens)
ASAP1 [cytosol] (Homo sapiens)
RAB3IP and RAB8A bind to the ciliary targeting complex (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
ASAP1 dimer [cytosol] (Homo sapiens)
ASAP1 [cytosol] (Homo sapiens)
RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
ASAP1 dimer [cytosol] (Homo sapiens)
ASAP1 [cytosol] (Homo sapiens)
RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
ASAP1 dimer [cytosol] (Homo sapiens)
ASAP1 [cytosol] (Homo sapiens)
RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
ASAP1 dimer [cytosol] (Homo sapiens)
ASAP1 [cytosol] (Homo sapiens)
The exocyst complex binds to RAB3IP in the ciliary targeting complex (Homo sapiens)
RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
ASAP1 dimer [cytosol] (Homo sapiens)
ASAP1 [cytosol] (Homo sapiens)
exocyst complex:RAB8A:GTP:RAB3IP:RAB11:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
ASAP1 dimer [cytosol] (Homo sapiens)
ASAP1 [cytosol] (Homo sapiens)
VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Homo sapiens)
exocyst complex:RAB8A:GTP:RAB3IP:RAB11:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
ASAP1 dimer [cytosol] (Homo sapiens)
ASAP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9ULH1 ASAP1
Gene Names
ASAP1, DDEF1, KIAA1249, PAG2
Chain
chain:1-1129
Reference Genes
BioGPS Gene:50807 ASAP1
COSMIC (genes):ASAP1 ASAP1
CTD Gene:50807 ASAP1
dbSNP Gene:50807 ASAP1
ENSEMBL:ENSG00000153317 ASAP1
ENSEMBL_homo_sapiens_GENE:ENSG00000153317.15 ASAP1
HGNC:2720 ASAP1
KEGG Gene (Homo sapiens):50807 ASAP1
Monarch:50807 ASAP1
NCBI Gene:50807 ASAP1
OMIM:605953 ASAP1
UCSC:Q9ULH1 ASAP1
Reference Transcript
RefSeq:NM_001247996.1 ASAP1
RefSeq:XM_006716563.3 ASAP1
RefSeq:XM_011517052.2 ASAP1
RefSeq:NM_018482.3 ASAP1
RefSeq:XM_005250925.1 ASAP1
Other Identifiers
11717281_a_at
11717282_at
11717283_a_at
11755032_s_at
17081162
221039_PM_s_at
221039_s_at
224790_PM_at
224790_at
224791_PM_at
224791_at
224796_PM_at
224796_at
236533_PM_at
236533_at
3153429
3153430
3153431
3153432
3153433
3153434
3153435
3153438
3153440
3153444
3153447
3153453
3153454
3153468
3153469
3153473
3153475
3153476
3153477
3153478
3153481
3153482
3153483
3153485
3153486
3153487
3153489
3153505
3153506
3153514
3153515
3153528
3153530
3153531
3153532
3153535
3153549
3153556
3153614
3153621
3153622
3153628
3153629
48803_at
50807
60030_at
69516_at
8152867
A_23_P216278
A_23_P44831
A_23_P71526
A_33_P3775007
GE53850
GE82388
GO:0000139
GO:0001786
GO:0002102
GO:0005096
GO:0005515
GO:0005546
GO:0005547
GO:0005737
GO:0005794
GO:0005829
GO:0005856
GO:0008289
GO:0016020
GO:0030030
GO:0030154
GO:0032588
GO:0034330
GO:0043197
GO:0043226
GO:0043547
GO:0044782
GO:0045296
GO:0046872
GO:0048856
GO:0060271
GO:0061000
GO:0061024
GO:0061512
GO:0098772
GO:0098978
GO:0099175
GO:1903527
HMNXSV003043886
Hs.10669.1.S1_3p_at
Hs.10669.1.S2_3p_at
Hs.10669.1.S3_3p_at
Hs.199057.0.A1_3p_at
ILMN_1690963
ILMN_2233366
PH_hs_0024401
PH_hs_0036086
RNA147148|p0252_imsncRNA402
TC08001641.hg
TC08002532.hg
g8923867_3p_a_at
Participates
as a component of
ASAP1 dimer [cytosol] (Homo sapiens)
Inferred To
ASAP1 [cytosol]
(Bos taurus)
ASAP1 [cytosol]
(Canis familiaris)
ASAP1 [cytosol]
(Gallus gallus)
ASAP1 [cytosol]
(Sus scrofa)
Ghost homologue of ASAP1 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of ASAP1 [cytosol]
(Danio rerio)
Ghost homologue of ASAP1 [cytosol]
(Xenopus tropicalis)
Asap [cytosol]
(Drosophila melanogaster)
Asap1 [cytosol]
(Mus musculus)
Asap1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001234925.1
,
NP_060952.2
,
XP_005250982.1
,
XP_006716626.1
,
XP_011515354.1
OpenTargets
ENSG00000153317
HPA
ENSG00000153317-ASAP1
GeneCards
Q9ULH1
Ensembl
ENSP00000429900
,
ENST00000518721
,
ENSG00000153317
PRO
Q9ULH1
Pharos - Targets
Q9ULH1
HMDB Protein
HMDBP10723
PDB
2ED1
,
2D1X
,
2DA0
,
2RQT
,
2RQU
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.906
12
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [plasma membrane]
(R-HSA-182955)
SH3KBP1 [cytosol]
(R-HSA-182957)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.848
13
UniProt:Q14247 CTTN
2
CTTN [cytosol]
(R-HSA-201894)
p-S113-CTTN [cytosol]
(R-HSA-442842)
0.765
7
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.669
5
UniProt:P16333 NCK1
2
NCK1 [cytosol]
(R-HSA-197954)
NCK1 [plasma membrane]
(R-HSA-202992)
0.609
6
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.609
3
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.609
3
UniProt:P08631 HCK
2
p-HCK [cytosol]
(R-HSA-9676060)
HCK [cytosol]
(R-HSA-167708)
0.609
2
UniProt:P19174 PLCG1
6
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
0.602
3
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.527
2
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.524
2
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