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HECTD1 [cytosol]
Stable Identifier
R-HSA-5688966
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase HECTD1 ecNumber6.3.2.-/ecNumber, HECD1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9ULT8 HECTD1
Gene Names
HECTD1, KIAA1131
Chain
chain:1-2610
Reference Genes
BioGPS Gene:25831 HECTD1
COSMIC (genes):HECTD1 HECTD1
CTD Gene:25831 HECTD1
dbSNP Gene:25831 HECTD1
ENSEMBL:ENSG00000092148 HECTD1
HGNC:20157 HECTD1
KEGG:hsa:25831 HECTD1
Monarch:25831 HECTD1
NCBI Gene:25831 HECTD1
OMIM:618649 HECTD1
UCSC:Q9ULT8 HECTD1
Reference Transcript
RefSeq:XM_054375770.1 HECTD1
RefSeq:NM_015382.4 HECTD1
RefSeq:XM_005267502.4 HECTD1
Other Identifiers
11727479_a_at
1557100_PM_s_at
1557100_s_at
1570251_PM_at
1570251_at
16791669
224481_PM_s_at
224481_s_at
241683_PM_at
241683_at
241955_PM_at
241955_at
242349_PM_at
242349_at
25831
3559573
3559574
3559575
3559576
3559577
3559578
3559579
3559580
3559581
3559582
3559583
3559584
3559585
3559586
3559587
3559588
3559592
3559593
3559595
3559597
3559598
3559599
3559600
3559601
3559602
3559604
3559605
3559606
3559607
3559608
3559609
3559610
3559611
3559612
3559613
3559614
3559615
3559616
3559617
3559618
3559619
3559620
3559621
3559622
3559623
3559624
3559625
3559626
3559627
3559629
3559630
3559631
3559632
3559634
3559635
3559636
3559639
3559640
3559641
3559642
3559643
3559644
3559645
3559646
3559647
3559648
3559649
3559651
3559654
3559655
3559656
3559657
3559658
3559659
3559660
3559661
3559662
45304_at
68210_at
72016_at
7978449
85047_at
86985_i_at
86988_r_at
A_23_P54006
A_24_P547659
A_24_P923076
GE61739
GE730115
GO:0003170
GO:0003281
GO:0003824
GO:0004842
GO:0005515
GO:0006511
GO:0016567
GO:0016740
GO:0032436
GO:0035904
GO:0046872
GO:0048856
GO:0061630
GO:0140096
HMNXSV003021011
Hs.190223.0.S1_3p_at
Hs.314346.0.S1_3p_at
Hs.322848.0.A1_3p_at
Hs2.407239.1.S1_3p_at
Hs2.421481.1.S1_3p_x_at
ILMN_1706094
PH_hs_0012222
TC14001009.hg
g13623274_3p_s_at
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_056197.3
,
XP_005267559.2
,
XP_054231745.1
ENSEMBL
ENSG00000092148
,
ENSP00000382269
,
ENST00000399332
,
ENSP00000450697
,
ENST00000553700
OpenTargets
ENSG00000092148
GeneCards
HECTD1
HPA
ENSG00000092148-HECTD1
PRO
Q9ULT8
Pharos - Targets
Q9ULT8
GlyGen
Q9ULT8
PDB
3DKM
,
2LC3
,
2DK3
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.536
3
UniProt:Q7Z624 CAMKMT
1
CAMKMT [cytosol]
(R-HSA-6786199)
0.527
2
UniProt:O75496 GMNN
2
GMNN [nucleoplasm]
(R-HSA-113554)
PolyUb-GMNN [nucleoplasm]
(R-HSA-68585)
0.527
2
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.483
2
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