Reactome | YWHAZ [nucleoplasm]

YWHAZ [nucleoplasm]

Stable Identifier

R-HSA-450469

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

14-3-3zeta

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P63104 YWHAZ

Gene Names

YWHAZ

Chain

chain:1-245

Reference Genes

BioGPS Gene:7534 YWHAZ

COSMIC (genes):YWHAZ YWHAZ

CTD Gene:7534 YWHAZ

dbSNP Gene:7534 YWHAZ

ENSEMBL:ENSG00000164924 YWHAZ

ENSEMBL:ENSG00000164924.18 YWHAZ

HGNC:12855 YWHAZ

KEGG Gene (Homo sapiens):7534 YWHAZ

Monarch:7534 YWHAZ

NCBI Gene:7534 YWHAZ

OMIM:601288 YWHAZ

UCSC:P63104 YWHAZ

Reference Transcript

Other Identifiers

11756181_x_at

11758667_x_at

11758711_x_at

11758750_x_at

11758751_at

11758752_x_at

1235_at

1556496_PM_a_at

1556496_a_at

17079711

17120418

200638_PM_s_at

200638_s_at

200639_PM_s_at

200639_s_at

200640_PM_at

200640_at

200641_PM_s_at

200641_s_at

214848_PM_at

214848_at

2574516

2574517

2924960

3146891

3146893

3146895

3146897

3146899

3146900

3146901

3146902

3146903

3146904

3146905

3146906

3146911

3146912

3146913

3146930

3146931

3146933

3146939

3146940

3146941

3146942

3146943

3146944

3146950

3146951

3146952

3146953

3146954

3146955

3204097

3204098

3238808

3238818

3238820

3262898

34642_at

36760_at

3694476

3749823

4005925

4005976

55272_at

7534

8152096

A_19_P00802601

A_24_P209571

A_24_P532478

GE548889

GE58115

GE59443

GE80033

GO:0000122

GO:0002376

GO:0003723

GO:0003824

GO:0004497

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005925

GO:0006351

GO:0006355

GO:0006468

GO:0007165

GO:0012501

GO:0016491

GO:0019901

GO:0023052

GO:0031410

GO:0031625

GO:0031982

GO:0034330

GO:0036211

GO:0042470

GO:0042802

GO:0043066

GO:0043226

GO:0044325

GO:0045296

GO:0045824

GO:0048856

GO:0050815

GO:0051683

GO:0070062

GO:0070372

GO:0072562

GO:0090128

GO:0090168

GO:0098542

GO:0098978

GO:0140297

GO:0140311

GO:0140313

GO:1900181

HMNXSV003006124

HMNXSV003052498

Hs.71848.0.S1_3p_at

Hs2.58429.1.S1_3p_s_at

ILMN_1669286

ILMN_1801928

M86400_at

PH_hs_0040263

TC08001485.hg

TC08002448.hg

TC08002449.hg

TC08002451.hg

TC10000164.hg

U79277_at

g13177678_3p_a_at

g4507952_3p_a_at

g899458_3p_a_at

p15857

Participates

as a component of

as an input of

Other forms of this molecule

YWHAZ [cytosol]

Inferred To

14-3-3zeta [nucleoplasm] (Drosophila melanogaster)

ywhaz [nucleoplasm] (Xenopus tropicalis)

ftt-2 [nucleoplasm] (Caenorhabditis elegans)

fttB [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of YWHAZ [nucleoplasm] (Danio rerio)

YWHAZ [nucleoplasm] (Bos taurus)

YWHAZ [nucleoplasm] (Canis familiaris)

YWHAZ [nucleoplasm] (Gallus gallus)

YWHAZ [nucleoplasm] (Sus scrofa)

Ywhaz [nucleoplasm] (Mus musculus)

Ywhaz [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_016869300.1, NP_001129172.1, NP_663723.1, NP_001129174.1, NP_003397.1, NP_001129173.1, NP_001129171.1, XP_016869299.1, XP_005251120.1, XP_005251118.1

OpenTargets

ENSG00000164924

HPA

ENSG00000164924-YWHAZ

GeneCards

P63104

Ensembl

ENST00000522542, ENSP00000395114, ENSP00000309503, ENSP00000430072, ENST00000395958, ENSP00000379288, ENSP00000379287, ENST00000395956, ENSG00000164924, ENST00000419477, ENST00000395953, ENST00000395957, ENST00000395951, ENSP00000379283, ENST00000353245, ENSP00000398599, ENST00000457309, ENSP00000379286, ENSP00000379281

PRO

P63104

Pharos - Targets

P63104

HMDB Protein

HMDBP02552

PDB

6ZFD, 6XAG, 3CU8, 8A9G, 1QJB, 5ULO, 6Q0K, 7MFE, 5M36, 7D8P, 6YO8, 7MFF, 6U2H, 6F08, 4N84, 6FNA, 5M35, 4FJ3, 5D3F, 4ZDR, 5EXA, 6FN9, 6YOS, 4IHL, 5J31, 7D9V, 8AH2, 6ZFG, 5JM4, 3NKX, 4BG6, 5EWZ, 6YMO, 4N7G, 6FNC, 2C1J, 6F09, 6FNB, 6EWW, 7ZIT, 5M37, 5XY9, 6EF5, 4WRQ, 7Q16, 2WH0, 6RLZ, 7D8H, 4HKC, 5WXN, 4N7Y, 5D2D, 3RDH, 1IB1, 7MFD, 2C1N, 5NAS, 1QJA, 2O02, 6EJL

Interactors (161)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.962	31
UniProt:P30305 CDC25B	3	p-S50,T69,S160,S321,S470-CDC25B [cytosol] (R-HSA-8863644) CDC25B [cytosol] (R-HSA-157412) CDC25B [nucleoplasm] (R-HSA-69734)	0.924	10
UniProt:P27448 MARK3	1	MARK3 [cytosol] (R-HSA-5672591)	0.922	12
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.91	11
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.907	11
UniProt:P49815 TSC2	4	p-S939,S1130,T1462-TSC2 [cytosol] (R-HSA-165164) p-S939,T1462-TSC2 [cytosol] (R-HSA-199484) TSC2 [cytosol] (R-HSA-2980548) p-S1387-TSC2 [cytosol] (R-HSA-3132769)	0.903	10
UniProt:Q7KZI7 MARK2			0.883	8
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.864	9
UniProt:O96013 PAK4	1	PAK4 [cytosol] (R-HSA-428461)	0.864	7
UniProt:Q92934 BAD	4	p-S99-BAD [cytosol] (R-HSA-198335) BAD [cytosol] (R-HSA-50662) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S91-BAD [cytosol] (R-HSA-217297)	0.851	8
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.845	7
UniProt:P54253 ATX1			0.845	12
UniProt:Q02241 KIF23	3	KIF23 [nucleoplasm] (R-HSA-156709) p-S911,S912-KIF23 [nucleoplasm] (R-HSA-156695) KIF23 [cytosol] (R-HSA-1015863)	0.836	6
UniProt:P56524 HDAC4	3	polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) HDAC4 [nucleoplasm] (R-HSA-351581)	0.809	6
UniProt:P46937 YAP1	7	p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322)	0.803	9
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.772	6
UniProt:P40818 USP8	2	USP8 [cytosol] (R-HSA-917720) p-T945-USP8 [cytosol] (R-HSA-1358714)	0.77	4
UniProt:P33176 KIF5B	3	KIF5B(2-575)-ALK(1063-1620) fusion [cytosol] (R-HSA-9711964) KIF5B(2-575)-p-7Y-ALK(1063-1620) fusion [cytosol] (R-HSA-9711937) KIF5B [cytosol] (R-HSA-265181)	0.77	4
UniProt:P26045 PTPN3	3	PTPN3 [plasma membrane] (R-HSA-5490317) p-S459 PTPN3 [cytosol] (R-HSA-8868111) PTPN3 [cytosol] (R-HSA-8867650)	0.763	5
UniProt:Q8WUI4 HDAC7	1	HDAC7 [nucleoplasm] (R-HSA-3004534)	0.744	4
UniProt:Q02156 PRKCE	2	p-T566,T710,S729-PRKCE [plasma membrane] (R-HSA-198260) PRKCE [cytosol] (R-HSA-58202)	0.729	7
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.725	7
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.725	5
UniProt:Q8TEW0 PARD3	3	PARD3 [plasma membrane] (R-HSA-419980) PARD3 [cytosol] (R-HSA-419993) PARD3 [cell junction] (R-HSA-2134481)	0.723	5
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT [cytosol] (R-HSA-201574)	0.723	8
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.716	4
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.702	3
UniProt:Q9NYL2 M3K20			0.696	5
UniProt:P06733 ENO1	1	ENO1 [cytosol] (R-HSA-71437)	0.692	3
UniProt:Q9NSK0 KLC4	1	KLC4 [cytosol] (R-HSA-983244)	0.688	3
UniProt:O43524 FOXO3	9	p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) p-S215 FOXO3 [cytosol] (R-HSA-5687014) FOXO3 [cytosol] (R-HSA-5687032) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) FOXO3 [nucleoplasm] (R-HSA-199305)	0.688	3
UniProt:Q86X27 RGPS2			0.688	4
UniProt:O95544 NADK	1	NADK [cytosol] (R-HSA-197282)	0.688	3
UniProt:Q5PRF9 SMAG2			0.688	3
UniProt:P25705 ATP5F1A	3	ATP5A1 [mitochondrial matrix] (R-HSA-164575) ATP5A1(1-553) [cytosol] (R-HSA-1267955) ATP5A1(1-553) [mitochondrial intermembrane space] (R-HSA-1267978)	0.688	4
UniProt:Q9P0K7 RAI14			0.688	3
UniProt:Q9H0B6 KLC2	1	KLC2 [cytosol] (R-HSA-983191)	0.688	3
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.678	4
UniProt:P57059 SIK1	1	SIK1 [nucleoplasm] (R-HSA-5656504)	0.677	5
UniProt:O95685 PPR3D			0.675	4
UniProt:P05783 KRT18	1	KRT18 [cytosol] (R-HSA-201582)	0.669	3
UniProt:Q92974 ARHGEF2	1	ARHGEF2 [cytosol] (R-HSA-195101)	0.669	3
UniProt:Q13625 TP53BP2	1	TP53BP2 [nucleoplasm] (R-HSA-6799780)	0.669	3
UniProt:Q9UQL6 HDAC5	1	HDAC5 [nucleoplasm] (R-HSA-3004533)	0.669	3
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.669	3
UniProt:Q9Y4H2 IRS2	4	IRS2 [plasma membrane] (R-HSA-2428927) IRS2 [cytosol] (R-HSA-57528) p-Y-IRS2 [cytosol] (R-HSA-74774) p-Y-IRS2 [plasma membrane] (R-HSA-198334)	0.669	3
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.656	3
UniProt:P61587 RND3	1	RND3 [plasma membrane] (R-HSA-9696265)	0.655	11
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.646	3
UniProt:Q9UQC2 GAB2	5	p-Y643-GAB2 [cytosol] (R-HSA-9677149) p-5Y-GAB2 [cytosol] (R-HSA-8855574) p-Y-GAB2 [cytosol] (R-HSA-912529) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) GAB2 [cytosol] (R-HSA-508239)	0.643	4
UniProt:Q61337 Bad	6	phospho-Bad [cytosol] (R-MMU-217297) Bad [mitochondrial outer membrane] (R-MMU-114242) p-S136-Bad [cytosol] (R-MMU-3139049) Bad [cytosol] (R-MMU-3139043) Bad [cytosol] (R-MMU-50662) phospho-Bad [cytosol] (R-MMU-198335)	0.643	3
UniProt:Q9P0L2 MARK1			0.643	3
UniProt:Q9Y2U5 M3K2			0.643	3
UniProt:P68431 H3C1	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791)	0.643	3
UniProt:Q9Y3M2 CBY1	3	pS20-CBY1 [nucleoplasm] (R-HSA-3769356) CBY1 [nucleoplasm] (R-HSA-3769210) pS20-CBY1 [cytosol] (R-HSA-3769354)	0.643	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.643	4
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.643	5
UniProt:Q01113 IL9R	2	p-Y407-IL9R [plasma membrane] (R-HSA-8985904) IL9R [plasma membrane] (R-HSA-449790)	0.635	5
UniProt:P67828 KC1A			0.632	4
UniProt:Q9P0K1 ADAM22	1	ADAM22 [plasma membrane] (R-HSA-5678678)	0.626	5
UniProt:P00519 ABL1	5	p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.623	3
UniProt:P54256-2 HAP1			0.619	4
UniProt:P10636-3 MAPT			0.618	9
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	14
UniProt:Q15831 STK11	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.61	6
UniProt:P30793 GCH1	1	GCH1 [cytosol] (R-HSA-1474127)	0.602	4
UniProt:Q29495 SNAT			0.602	3
UniProt:Q16890 TPD52L1	2	TPD52L1 [cytoplasmic vesicle lumen] (R-HSA-434220) TPD52L1 [Golgi lumen] (R-HSA-434331)	0.593	3
UniProt:P84198 VIME			0.591	5
UniProt:Q9UDY2 TJP2	4	TJP2 [cytosol] (R-HSA-2064412) TJP2 [nucleoplasm] (R-HSA-2064410) TJP2 [plasma membrane] (R-HSA-351862) TJP2(?-?) [plasma membrane] (R-HSA-351897)	0.589	2
UniProt:Q96F86 EDC3	1	EDC3 [cytosol] (R-HSA-429997)	0.589	2
UniProt:Q9Y2J2 EPB41L3	1	EPB41L3 [cytosol] (R-HSA-6797563)	0.589	2
UniProt:O00273 DFFA	6	DFFA [cytosol] (R-HSA-211221) DFFA(1-?) [nucleoplasm] (R-HSA-211228) DFFA(225-331) [nucleoplasm] (R-HSA-211188) DFFA(118-224) [nucleoplasm] (R-HSA-211205) DFFA(118-331) [nucleoplasm] (R-HSA-211199) DFFA(1-117) [nucleoplasm] (R-HSA-211185)	0.589	2
UniProt:P62995 TRA2B	2	TRA2B [cytosol] (R-HSA-9715137) TRA2B [nucleoplasm] (R-HSA-8850859)	0.589	2
UniProt:Q14978 NOLC1			0.589	2
UniProt:Q13310 PABP4			0.589	2
UniProt:Q9P0K1-3 ADAM22			0.581	3
UniProt:Q9Y2K2 SIK3			0.577	5
UniProt:P16104 H2AX	7	K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) H2AFX [nucleoplasm] (R-HSA-56151) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.577	6
UniProt:O94875 SRBS2			0.573	2
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [secretory granule lumen] (R-HSA-6801039) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [cytosol] (R-HSA-1181251)	0.573	2
UniProt:Q5T5U3 ARHGAP21	1	ARHGAP21 [cytosol] (R-HSA-8873918)	0.564	2
UniProt:O15151 MDM4	5	PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) MDM4 [nucleoplasm] (R-HSA-349430)	0.564	2
UniProt:Q71U36 TUBA1A	9	AcK-TUBA1A [cytosol] (R-HSA-5618312) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) TUBA1A folding intermediate [cytosol] (R-HSA-392805) TUBA1A unfolded [cytosol] (R-HSA-392767) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433) TUBA1A(1-450) [cytosol] (R-HSA-8955577)	0.564	4
UniProt:Q7L8J4 3BP5L			0.564	2
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.564	3
UniProt:Q9P2M7 CGN	1	CGN [cell junction] (R-HSA-2134478)	0.564	3
UniProt:Q16658 FSCN1	1	FSCN1 [cytosol] (R-HSA-6789835)	0.564	3
UniProt:O60343 TBC1D4	2	p-5S,T642-TBC1D4 [cytoplasmic vesicle membrane] (R-HSA-1445101) TBC1D4 [cytoplasmic vesicle membrane] (R-HSA-1445122)	0.564	2
UniProt:P68104 EEF1A1	7	Me3K79-EEF1A1 [cytosol] (R-HSA-8932212) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [lysosomal membrane] (R-HSA-9626022)	0.564	2
UniProt:P06576 ATP5F1B	6	ATP5B [mitochondrial inner membrane] (R-HSA-1299441) ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B [mitochondrial matrix] (R-HSA-164576)	0.564	2
UniProt:Q6ICG6 K0930			0.564	2
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.564	3
UniProt:O75044 SRGAP2	1	SRGAP2 [cytosol] (R-HSA-195131)	0.564	2
UniProt:Q7Z401 DENND4A	1	DENND4A [cytosol] (R-HSA-8876072)	0.564	2
UniProt:Q9Y4D8 HECD4			0.564	2
UniProt:P30307 CDC25C	8	p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654) p-S191-CDC25C [nucleoplasm] (R-HSA-6802968) p-S216-CDC25C [cytosol] (R-HSA-75003) p-S216-CDC25C [nucleoplasm] (R-HSA-156496) CDC25C [nucleoplasm] (R-HSA-69741) p-S198-CDC25C [cytosol] (R-HSA-8981697) CDC25C [cytosol] (R-HSA-157879) p-S198-CDC25C [nucleoplasm] (R-HSA-156668)	0.564	2
UniProt:P02545 LMNA	3	LMNA(1-646) [nuclear envelope] (R-HSA-535479) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537)	0.564	2
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.564	2
UniProt:Q99759 MAP3K3	1	MAP3K3 [cytosol] (R-HSA-507725)	0.564	2
UniProt:P31327 CPS1	1	CPS1 [mitochondrial matrix] (R-HSA-70544)	0.564	2
UniProt:Q12802 AKAP13	1	AKAP13 [cytosol] (R-HSA-2975983)	0.564	2
UniProt:Q7Z6B7 SRGAP1	1	SRGAP1 [cytosol] (R-HSA-428453)	0.564	2
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.564	2
UniProt:O60825 PFKFB2	1	PFKFB2 [cytosol] (R-HSA-71790)	0.564	2
UniProt:P0C0S8 H2AC11	11	K63polyUb-HIST1H2AG [nucleoplasm] (R-HSA-6783237) Ub-HIST1H2AG [nucleoplasm] (R-HSA-6782508) Ack6-HIST1H2AG [nucleoplasm] (R-HSA-4568595) Me2aR30-HIST1H2AG [nucleoplasm] (R-HSA-5244582) MeR30-HIST1H2AG [nucleoplasm] (R-HSA-5244560) Me2aR4-HIST1H2AG [nucleoplasm] (R-HSA-5244587) MeR4-HIST1H2AG [nucleoplasm] (R-HSA-5244623) Me2aR12-HIST1H2AG [nucleoplasm] (R-HSA-5229305) MeR12-HIST1H2AG [nucleoplasm] (R-HSA-5229206) HIST1H2AG [nucleoplasm] (R-HSA-212084) Ack-HIST1H2AG [nucleoplasm] (R-HSA-4551311)	0.564	2
UniProt:Q07866 KLC1	3	KLC1(1-420)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711978) KLC1(1-420)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711968) KLC1 [cytosol] (R-HSA-983284)	0.564	2
UniProt:O75592 MYCB2			0.564	2
UniProt:O00750 PIK3C2B	1	PIK3C2B [cytosol] (R-HSA-1604619)	0.564	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.564	2
UniProt:P23396 RPS3	2	RPS3 [nucleoplasm] (R-HSA-6798714) RPS3 [cytosol] (R-HSA-72369)	0.564	2
UniProt:O60292 SI1L3			0.564	2
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [lysosomal membrane] (R-HSA-196160) ACTB(1-375) [plasma membrane] (R-HSA-196016)	0.564	3
UniProt:Q00537 CDK17			0.564	3
UniProt:P62158 CALM			0.564	2
UniProt:Q6P597 KLC3	1	KLC3 [cytosol] (R-HSA-983232)	0.564	2
UniProt:Q6WCQ1 MPRIP	2	MPRIP(2-1015)-RAF1(279-648) fusion [cytosol] (R-HSA-6802406) MPRIP(2-1015)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802540)	0.564	2
UniProt:Q5VV41 ARHGEF16	1	ARHGEF16 [cytosol] (R-HSA-2976623)	0.564	2
UniProt:O14980 XPO1	2	XPO1 [nucleoplasm] (R-HSA-165529) XPO1 [cytosol] (R-HSA-165539)	0.564	2
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.564	2
UniProt:P10636-2 MAPT			0.558	2
UniProt:P36897 TGFBR1	13	Ub-TGFBR1 [plasma membrane] (R-HSA-8869461) p-4S,T185,T186-TGFBR1 W242* [plasma membrane] (R-HSA-3656504) p-4S,T185,T186-TGFBR1 P327Qfs8 [plasma membrane] (R-HSA-3656505) p-4S,T185,T186-TGFBR1 L354Nfs4 [plasma membrane] (R-HSA-3656506) p-4S,T185,T186-TGFBR1 R414* [plasma membrane] (R-HSA-3656508) p-4S,T185,T186-TGFBR1 D269_Q324del [plasma membrane] (R-HSA-3656509) TGFBR1 G52R [plasma membrane] (R-HSA-3656368) TGFBR1 C41Y [plasma membrane] (R-HSA-3656328) TGFBR1 N45S [plasma membrane] (R-HSA-3656348) TGFBR1 P83L [plasma membrane] (R-HSA-3656341) TGFBR1 P83S [plasma membrane] (R-HSA-3656326) TGFBR1 [plasma membrane] (R-HSA-170839) p-4S,T185,T186-TGFBR1 [plasma membrane] (R-HSA-170849)	0.556	4
UniProt:Q86Z20 CC125			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q9Y4H4 GPSM3	1	GPSM3 [cytosol] (R-HSA-8949486)	0.556	5
UniProt:Q9NRI5 DISC1			0.553	3
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.553	2
UniProt:P60520 GABARAPL2	3	GABARAPL2 [autophagosome membrane] (R-HSA-5683633) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [cytosol] (R-HSA-5671758)	0.547	2
UniProt:O43896 KIF1C	1	KIF1C [cytosol] (R-HSA-8849365)	0.547	2
UniProt:Q15884 EREP1			0.547	2
UniProt:P30304 CDC25A	6	PolyUb-CDC25A [cytosol] (R-HSA-6782810) CDC25A [nucleoplasm] (R-HSA-143487) CDC25A [cytosol] (R-HSA-157410) p-S124-CDC25A [nucleoplasm] (R-HSA-143488) p-S124-CDC25A [cytosol] (R-HSA-69588) p-S40,S116,S261-CDC25A [nucleoplasm] (R-HSA-8863634)	0.544	2
UniProt:P29172 TAU			0.544	2
UniProt:P30291 WEE1	3	p-WEE1 [nucleoplasm] (R-HSA-156491) p-S53-WEE1 [nucleoplasm] (R-HSA-156694) WEE1 [nucleoplasm] (R-HSA-69253)	0.544	3
UniProt:Q6P6S3 BSPRY			0.543	3
UniProt:Q9H1R3 MYLK2			0.527	3
UniProt:Q6R327 RICTOR	1	RICTOR [cytosol] (R-HSA-198632)	0.527	2
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.527	3
UniProt:Q63767	4	phospho-Bcar1 [cytosol] (R-RNO-372645) phospho-Bcar1 [cytosol] (R-RNO-5218739) phospho-Bcar1 [cytosol] (R-RNO-8848723) Bcar1 [cytosol] (R-RNO-201625)	0.527	2
UniProt:Q6VAB6 KSR2	1	KSR2 [cytosol] (R-HSA-5672589)	0.527	6
UniProt:Q5TCX8 M3K21			0.527	2
UniProt:Q9NQU5 PAK6	1	PAK6 [cytosol] (R-HSA-428454)	0.527	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	3
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) MAP2K1 Q56P [cytosol] (R-HSA-9652064) MAP2K1 E203K [cytosol] (R-HSA-9652023) MAP2K1 V60E [cytosol] (R-HSA-9652067) MAP2K1 P124S [cytosol] (R-HSA-9652062) MAP2K1 Y130C [cytosol] (R-HSA-9652101) MAP2K1 C121S [cytosol] (R-HSA-9652013) MAP2K1 G128V [cytosol] (R-HSA-9652047) MAP2K1 F53L [cytosol] (R-HSA-9652031) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026)	0.527	4
UniProt:P49796 RGS3	1	RGS3 [plasma membrane] (R-HSA-8849410)	0.527	2
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.527	2
UniProt:Q8WYL5 SSH1			0.527	2
UniProt:P07101 TH	1	TH [cytosol] (R-HSA-2980863)	0.527	2
UniProt:Q13470 TNK1			0.527	2
UniProt:P29074 PTPN4	2	PTPN4 [nucleoplasm] (R-HSA-9008925) PTPN4 [cytosol] (R-HSA-8877173)	0.527	2
UniProt:Q12778 FOXO1	5	p-S218-FOXO1 [nucleoplasm] (R-HSA-5692651) FOXO1 [nucleoplasm] (R-HSA-199300) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158) Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942)	0.527	3
UniProt:Q7L804 RAB11FIP2	1	RAB11FIP2 [cytoplasmic vesicle membrane] (R-HSA-2028707)	0.527	2
UniProt:Q00536 CDK16			0.527	2
UniProt:Q86VP3 PACS2			0.527	2
UniProt:P31946-2 YWHAB			0.527	2
UniProt:P29353 SHC1	5	SHC1 [cytosol] (R-HSA-74680) p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321)	0.527	2
UniProt:P07359 GP1BA	1	GP1BA [plasma membrane] (R-HSA-55861)	0.527	2
UniProt:Q8NFH8 REPS2	1	REPS2 [cytosol] (R-HSA-432938)	0.524	2
UniProt:O00257-3 CBX4			0.499	2
UniProt:Q51451 Q51451			0.469	2
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.462	3
UniProt:Q76353 Q76353			0.462	2

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