Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CDC40 [nucleoplasm]
Stable Identifier
R-HSA-72062
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
hPrp17, Pre-mRNA splicing factor PRP17 (hPRP17) (EH-binding protein 3) (Ehb3), Pre-mRNA splicing factor PRP17, hPRP17, Cell division cycle 40 homolog, EH-binding protein 3, Ehb3
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Transcription Termination (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
mRNA 3'-end processing (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Spliced mRNP [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
mRNA polyadenylation (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Disassembly of the Intron Lariat Spliceosome (new) (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Intron Lariat Spliceosome (ILS) [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal A complex (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B* complex (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Bact complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C complex containing intron lariat (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C* complex (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Pre-B complex (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
Intron Lariat Spliceosome (ILS) [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
CDC40 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60508 CDC40
Gene Names
CDC40, EHB3, PRP17, PRPF17
Chain
chain:1-579
Reference Genes
BioGPS Gene:51362 CDC40
COSMIC (genes):CDC40 CDC40
CTD Gene:51362 CDC40
dbSNP Gene:51362 CDC40
ENSEMBL:ENSG00000168438 CDC40
HGNC:17350 CDC40
KEGG:hsa:51362 CDC40
Monarch:51362 CDC40
NCBI Gene:51362 CDC40
OMIM:605585 CDC40
UCSC:O60508 CDC40
Reference Transcript
RefSeq:NM_015891.2 CDC40
Other Identifiers
11720428_a_at
11720429_at
11753196_a_at
17011635
203376_PM_at
203376_at
203377_PM_s_at
203377_s_at
2921091
2921092
2921093
2921094
2921095
2921097
2921099
2921100
2921101
2921103
2921104
2921105
2921106
2921107
2921108
2921110
2921115
2921118
2921119
2921120
2921122
2921125
2921126
2921127
2921128
2921129
2921130
2921131
2921132
2921136
2921137
37481_at
3976447
4007276
51362
61649_at
77496_at
8121461
91158_at
A_14_P113639
A_14_P121490
A_23_P33455
A_23_P351314
A_23_P351320
A_24_P414786
GE80118
GO:0000398
GO:0003723
GO:0003729
GO:0005515
GO:0005634
GO:0005654
GO:0005681
GO:0006397
GO:0008380
GO:0016071
GO:0016607
GO:0043226
GO:0048856
GO:0071007
GO:0071013
GO:1990403
HMNXSV003005259
HMNXSV003045444
Hs.116674.0.S2_3p_at
ILMN_1737651
PH_hs_0006393
TC06000882.hg
g7706656_3p_a_at
p33574
Participates
as an output of
Disassembly of the Intron Lariat Spliceosome (new) (Homo sapiens)
Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
as an input of
Formation of the Spliceosomal A complex (Homo sapiens)
as a component of
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
Intron Lariat Spliceosome (ILS) [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
Spliced mRNP [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
Inferred To
prp17 [nucleoplasm]
(Schizosaccharomyces pombe)
CDC40 [nucleoplasm]
(Bos taurus)
CDC40 [nucleoplasm]
(Canis familiaris)
CDC40 [nucleoplasm]
(Drosophila melanogaster)
CDC40 [nucleoplasm]
(Gallus gallus)
CDC40 [nucleoplasm]
(Plasmodium falciparum)
CDC40 [nucleoplasm]
(Saccharomyces cerevisiae)
CDC40 [nucleoplasm]
(Sus scrofa)
prp-17 [nucleoplasm]
(Caenorhabditis elegans)
cdc40 [nucleoplasm]
(Danio rerio)
cdc40 [nucleoplasm]
(Dictyostelium discoideum)
cdc40 [nucleoplasm]
(Xenopus tropicalis)
Cdc40 [nucleoplasm]
(Mus musculus)
Cdc40 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_056975.1
OpenTargets
ENSG00000168438
ENSEMBL
ENST00000368932
,
ENSP00000304370
,
ENST00000307731
,
ENSP00000357928
HPA
ENSG00000168438-CDC40
PRO
O60508
Pharos - Targets
O60508
PDB
8C6J
,
6ID0
,
6FF4
,
7AAV
,
6FF7
,
6ID1
,
6ICZ
,
7W59
,
7A5P
,
5MQF
,
7W5A
,
6QDV
,
5YZG
,
6ZYM
,
5Z57
,
7W5B
,
8CH6
,
5Z56
,
7ABI
,
5XJC
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UMS4 PRPF19
1
PRPF19 [nucleoplasm]
(R-HSA-5420907)
0.716
5
UniProt:P62306 SNRPF
2
SNRPF [cytosol]
(R-HSA-191852)
SNRPF [nucleoplasm]
(R-HSA-71907)
0.643
4
UniProt:Q9CSN1 Snw1
1
Snw1 [nucleoplasm]
(R-MMU-2065315)
0.564
2
UniProt:P14678 SNRPB
4
2xMe-SNRPB [cytosol]
(R-HSA-192218)
SNRPB [cytosol]
(R-HSA-191798)
Me2-R108,R112-SNRPB [nucleoplasm]
(R-HSA-192213)
SNRPB [nucleoplasm]
(R-HSA-71896)
0.527
2
UniProt:Q14562 DHX8
1
DHX8 [nucleoplasm]
(R-HSA-5688092)
0.527
2
UniProt:O95926 SYF2
1
SYF2 [nucleoplasm]
(R-HSA-8867884)
0.527
3
UniProt:P09661 SNRPA1
1
SNRPA1 [nucleoplasm]
(R-HSA-71958)
0.527
4
UniProt:P62304 SNRPE
2
SNRPE [cytosol]
(R-HSA-191782)
SNRPE [nucleoplasm]
(R-HSA-71905)
0.527
4
UniProt:Q12905 ILF2
5
ILF2 [cytosol]
(R-HSA-9836392)
ILF2 [specific granule lumen]
(R-HSA-6799611)
ILF2 [extracellular region]
(R-HSA-6799684)
ILF2 [tertiary granule lumen]
(R-HSA-6800995)
ILF2 [ficolin-1-rich granule lumen]
(R-HSA-6801001)
0.527
4
UniProt:Q96AT1 K1143
0.527
2
UniProt:Q9UHV9 PFDN2
1
PFDN2 [cytosol]
(R-HSA-379544)
0.527
2
UniProt:P63162 SNRPN
1
Me2-R108,R112-SNRPN [nucleoplasm]
(R-HSA-8865931)
0.527
2
UniProt:Q9BRX9 WDR83
1
WDR83 [endosome membrane]
(R-HSA-5672942)
0.527
4
UniProt:Q9BQ65 USB1
0.527
4
UniProt:Q86VM9 ZCH18
0.527
2
UniProt:Q9H307 PNN
1
PNN [nucleoplasm]
(R-HSA-9770779)
0.527
2
UniProt:Q86SE5 RALYL
0.527
2
UniProt:P09234 SNRPC
1
SNRPC [nucleoplasm]
(R-HSA-8865876)
0.527
2
UniProt:Q8TAD8 SNIP1
1
SNIP1 [nucleoplasm]
(R-HSA-3222315)
0.527
2
UniProt:Q99832 CCT7
1
CCT7 [cytosol]
(R-HSA-390451)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text