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EIF3A [cytosol]
Stable Identifier
R-HSA-72546
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF3-theta, eIF-3 theta, eIF3a, eIF3 p167, eIF3 p180, eIF3 p185, eukaryotic translation initiation factor 3 subunit 10, Eukaryotic translation initiation factor 3 subunit 10
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3A [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3A [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3A [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3A [cytosol] (Homo sapiens)
Formation of a pool of free 40S subunits (Homo sapiens)
eIF3 and eIF1A bind to the 40S subunit (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3A [cytosol] (Homo sapiens)
Formation of the ternary complex, and subsequently, the 43S complex (Homo sapiens)
Formation of the 43S pre-initiation complex (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3A [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3A [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3A [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3A [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3A [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3A [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3A [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14152 EIF3A
Gene Names
EIF3A, EIF3S10, KIAA0139
Chain
initiator methionine:, chain:2-1382
Reference Genes
BioGPS Gene:8661 EIF3A
COSMIC (genes):EIF3A EIF3A
CTD Gene:8661 EIF3A
dbSNP Gene:8661 EIF3A
ENSEMBL:ENSG00000107581 EIF3A
HGNC:3271 EIF3A
KEGG:hsa:8661 EIF3A
Monarch:8661 EIF3A
NCBI Gene:8661 EIF3A
OMIM:602039 EIF3A
UCSC:Q14152 EIF3A
Reference Transcript
RefSeq:NM_003750.2 EIF3A
Other Identifiers
11721470_s_at
11721471_a_at
16718870
17118774
200595_PM_s_at
200595_s_at
200596_PM_s_at
200596_s_at
200597_PM_at
200597_at
2558568
2844369
32785_at
3309244
3309245
3309246
3309247
3309248
3309249
3309250
3309256
3309258
3309259
3309262
3309264
3309265
3309266
3309267
3309268
3309269
3309270
3309271
3309272
3309273
3309274
3309276
3309280
3309282
3309283
3309284
3309285
3309286
3309288
3309290
3309291
72966_at
7893336
7936614
7936637
8661
A_21_P0000299
A_23_P86550
GE61440
GO:0001732
GO:0002183
GO:0002188
GO:0003723
GO:0003729
GO:0003743
GO:0005198
GO:0005515
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0005852
GO:0005874
GO:0006412
GO:0006413
GO:0014069
GO:0016020
GO:0016282
GO:0030971
GO:0032991
GO:0033290
GO:0043226
GO:0043614
GO:0045182
GO:0065003
GO:0070373
GO:0071540
GO:0071541
GO:0075522
GO:0075525
HMNXSV003009191
HMNXSV003057864
Hs.198899.0.S1_3p_a_at
Hs.198899.0.S1_3p_x_at
Hs.198899.0.S3_3p_at
ILMN_1708164
PH_hs_0027427
RNA33533|snoRNA_scaRNA_129_128
TC10001699.hg
U58046_s_at
g4503508_3p_a_at
Participates
as a component of
eIF3 subunits complex [cytosol] (Homo sapiens)
Inferred To
RPG1 [cytosol]
(Saccharomyces cerevisiae)
eIF3a [cytosol]
(Drosophila melanogaster)
egl-45 [cytosol]
(Caenorhabditis elegans)
eif3A [cytosol]
(Dictyostelium discoideum)
tif32 [cytosol]
(Schizosaccharomyces pombe)
eif3a [cytosol]
(Danio rerio)
eif3a [cytosol]
(Xenopus tropicalis)
EIF3A [cytosol]
(Bos taurus)
EIF3A [cytosol]
(Canis familiaris)
EIF3A [cytosol]
(Gallus gallus)
EIF3A [cytosol]
(Plasmodium falciparum)
EIF3A [cytosol]
(Sus scrofa)
Eif3a [cytosol]
(Mus musculus)
Eif3a [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_003741.1
ENSEMBL
ENST00000369144
,
ENSP00000358140
OpenTargets
ENSG00000107581
HPA
ENSG00000107581-EIF3A
PRO
Q14152
Pharos - Targets
Q14152
GlyGen
Q14152
PDB
7QP6
,
7QP7
,
6ZON
,
6ZP4
,
8OZ0
,
6YBD
,
6ZMW
,
7A09
,
6YBT
,
8XXN
,
3J8C
,
8PPL
,
6ZVJ
,
3J8B
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P23588 EIF4B
2
p-S422-EIF4B [cytosol]
(R-HSA-165773)
EIF4B [cytosol]
(R-HSA-72589)
0.667
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
11
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.569
7
UniProt:P06748 NPM1
11
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [granular component]
(R-HSA-9017702)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
0.527
2
UniProt:P47813 EIF1AX
1
EIF1AX [cytosol]
(R-HSA-72557)
0.525
2
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.488
2
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