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ZNF420 [nucleoplasm]
Stable Identifier
R-HSA-1247509
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Zinc finger protein 420, ZN420_HUMAN, Apak, ATM and p53-associated KZNF protein
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
KRAB-ZNF / KAP Interaction (Homo sapiens)
KRAB-ZNF / KAP Complex [nucleoplasm] (Homo sapiens)
KRAB-ZNF [nucleoplasm] (Homo sapiens)
ZNF420 [nucleoplasm] (Homo sapiens)
KRAB-ZNF [nucleoplasm] (Homo sapiens)
ZNF420 [nucleoplasm] (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
ATM phosphorylates ZNF420 (Homo sapiens)
ZNF420 [nucleoplasm] (Homo sapiens)
TP53 stimulates and ZNF420 inhibits TP53AIP1 expression (Homo sapiens)
ZNF420 [nucleoplasm] (Homo sapiens)
ZNF420:TP53AIP1 Gene [nucleoplasm] (Homo sapiens)
ZNF420 [nucleoplasm] (Homo sapiens)
ZNF420 binds TP53AIP1 gene (Homo sapiens)
ZNF420 [nucleoplasm] (Homo sapiens)
ZNF420:TP53AIP1 Gene [nucleoplasm] (Homo sapiens)
ZNF420 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TAQ5 ZNF420
Gene Names
ZNF420
Chain
chain:1-688
Reference Genes
BioGPS Gene:147923 ZNF420
COSMIC (genes):ZNF420 ZNF420
CTD Gene:147923 ZNF420
dbSNP Gene:147923 ZNF420
ENSEMBL:ENSG00000197050 ZNF420
HGNC:20649 ZNF420
KEGG Gene (Homo sapiens):147923 ZNF420
Monarch:147923 ZNF420
NCBI Gene:147923 ZNF420
UCSC:Q8TAQ5 ZNF420
Reference Transcript
RefSeq:NM_001329522.1 ZNF420
RefSeq:XM_011526503.2 ZNF420
RefSeq:XM_011526504.2 ZNF420
RefSeq:NM_144689.4 ZNF420
Other Identifiers
0006840722
11744188_at
147923
16861500
238937_at
242761_s_at
3831699
3831703
3831704
3831705
3831707
3831708
3831709
3831710
3831711
3831712
3831713
3831714
3831715
3831716
3831717
3831718
3831719
3831720
3831721
3831722
3831723
3831724
3871911
64224_at
76767_at
8028219
A_14_P105591
A_23_P380951
A_33_P3395389
A_33_P3395396
GE477890
GO:0000978
GO:0000981
GO:0003674
GO:0003677
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0006355
GO:0006357
GO:0008150
GO:0008219
GO:0009058
GO:0034641
GO:0042981
GO:0043167
GO:0043226
GO:0046872
HMNXSV003005573
HMNXSV003006014
Hs.133437.0.A1_3p_at
Hs.31511.0.A1_3p_at
ILMN_1720431
PH_hs_0008035
TC19000511.hg
Participates
as a candidate of
KRAB-ZNF [nucleoplasm] (Homo sapiens)
as an input of
ATM phosphorylates ZNF420 (Homo sapiens)
ZNF420 binds TP53AIP1 gene (Homo sapiens)
as a component of
ZNF420:TP53AIP1 Gene [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-S68-ZNF420 [nucleoplasm]
Inferred To
Dmel\CG8301 [nucleoplasm]
(Drosophila melanogaster)
ZNF383 [nucleoplasm]
(Bos taurus)
znf180 [nucleoplasm]
(Xenopus tropicalis)
Zfp420 [nucleoplasm]
(Mus musculus)
Zfp420 [nucleoplasm]
(Rattus norvegicus)
TFIIIA [nucleoplasm]
(Dictyostelium discoideum)
Homologues of ZNF420 [nucleoplasm]
(Bos taurus)
LOC100336984 [nucleoplasm]
(Bos taurus)
ZNF420 [nucleoplasm]
(Bos taurus)
ZNF420 [nucleoplasm]
(Canis familiaris)
ZNF420 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
XP_011524806.1
,
NP_653290.2
,
XP_011524805.1
,
NP_001316451.1
OpenTargets
ENSG00000197050
GeneCards
Q8TAQ5
HPA
ENSG00000197050-ZNF420
Ensembl
ENSP00000338770
,
ENSP00000306102
,
ENST00000304239
,
ENSG00000197050
,
ENST00000337995
PRO
Q8TAQ5
Pharos - Targets
Q8TAQ5
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8N726 CDKN2A
12
p14ARF [nucleoplasm]
(R-HSA-1629813)
p14ARF [cytosol]
(R-HSA-9645669)
p14ARF [mitochondrial matrix]
(R-HSA-9645695)
p14ARF R98L;R99S [cytosol]
(R-HSA-9645730)
p14ARF R82C [cytosol]
(R-HSA-9645750)
p14ARF R90H [cytosol]
(R-HSA-9645755)
p14ARF R88Q [cytosol]
(R-HSA-9645754)
p14ARF R87C [cytosol]
(R-HSA-9645759)
p14ARF R81G [cytosol]
(R-HSA-9645741)
p14ARF R98Q [cytosol]
(R-HSA-9645757)
p14ARF R99C [cytosol]
(R-HSA-9645756)
p14ARF R21RfsTER47 [cytosol]
(R-HSA-9646285)
0.644
8
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.591
4
UniProt:Q9NX04 CA109
0.556
3
UniProt:Q96LK0 CEP19
0.556
3
UniProt:P60409 KRTAP10-7
1
KRTAP10-7 [cytosol]
(R-HSA-6810279)
0.556
3
UniProt:P36508 ZNF76
0.556
3
UniProt:Q9NQT4 EXOSC5
2
EXOSC5 [cytosol]
(R-HSA-429889)
EXOSC5 [nucleoplasm]
(R-HSA-6791550)
0.556
3
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