Reactome | p-T180-STK3(1-491) [cytosol]

p-T180-STK3(1-491) [cytosol]

Stable Identifier

R-HSA-2028274

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-T180-STK3, p-STK3, phosphorylated Serine/threonine-protein kinase 3, p-MST2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13188 STK3

Gene Names

STK3, KRS1, MST2

Chain

chain:1-491, chain:1-322, chain:323-491

Reference Genes

BioGPS Gene:6788 STK3

COSMIC (genes):STK3 STK3

CTD Gene:6788 STK3

dbSNP Gene:6788 STK3

ENSEMBL:ENSG00000104375 STK3

HGNC:11406 STK3

KEGG:hsa:6788 STK3

Monarch:6788 STK3

NCBI Gene:6788 STK3

OMIM:605030 STK3

UCSC:Q13188 STK3

Reference Transcript

Other Identifiers

11721152_a_at

11721153_a_at

11721154_a_at

11758670_s_at

17079472

17079477

204068_PM_at

204068_at

211078_PM_s_at

211078_s_at

3146084

3146086

3146090

3146104

3146111

3146113

3146124

3146125

3146126

3146127

3146145

3146146

3146147

3146148

3146154

3146155

3146156

3146167

3146168

3146169

3146170

3146171

3146172

3146173

3146174

3146181

3146201

3146203

3146204

3146207

3146208

3146212

3146213

3146214

3146219

3146220

3146221

3146222

3146228

3146229

32142_at

6788

8151967

A_23_P215963

A_33_P3231363

A_33_P3260669

GE62016

GO:0000287

GO:0001841

GO:0003157

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006468

GO:0006606

GO:0006886

GO:0006913

GO:0006915

GO:0007165

GO:0007254

GO:0007417

GO:0008283

GO:0008285

GO:0008625

GO:0010468

GO:0012501

GO:0016301

GO:0016740

GO:0022414

GO:0030154

GO:0032991

GO:0035265

GO:0035329

GO:0035332

GO:0035556

GO:0042802

GO:0043065

GO:0043226

GO:0043408

GO:0043491

GO:0043539

GO:0045600

GO:0046330

GO:0046621

GO:0046872

GO:0048856

GO:0050673

GO:0050680

GO:0050821

GO:0051262

GO:0051897

GO:0060070

GO:0060215

GO:0060706

GO:0060800

GO:0065003

GO:0071539

GO:0090090

GO:0097284

GO:0098772

GO:0106310

GO:0140096

GO:0140537

GO:1902043

HMNXSV003012407

HMNXSV003016231

HMNXSV003034641

ILMN_1666453

PH_hs_0010029

TC08001463.hg

TC08002441.hg

TC08002442.hg

U26424_at

U60206_s_at

g405722_3p_s_at

g5454093_3p_at

p15849

Participates

as a component of

p-STK3 dimer [cytosol] (Homo sapiens)

Other forms of this molecule

STK3(1-491) [cytosol]

STK3(323-491) [cytosol]

p-T180-STK3(1-322) [cytosol]

Inferred To

Homologues of p-T180-STK3(1-491) [cytosol] (Caenorhabditis elegans)

phospho-p-T180-STK3(1-491) [cytosol] (Bos taurus)

phospho-p-T180-STK3(1-491) [cytosol] (Caenorhabditis elegans)

phospho-p-T180-STK3(1-491) [cytosol] (Danio rerio)

phospho-p-T180-STK3(1-491) [cytosol] (Drosophila melanogaster)

phospho-p-T180-STK3(1-491) [cytosol] (Mus musculus)

phospho-p-T180-STK3(1-491) [cytosol] (Rattus norvegicus)

phospho-p-T180-STK3(1-491) [cytosol] (Sus scrofa)

phospho-p-T180-STK3(1-491) [cytosol] (Xenopus tropicalis)

phospho-STK3 [cytosol] (Canis familiaris)

phospho-STK3 [cytosol] (Gallus gallus)

Modified Residues

Name

O-phospho-L-threonine at 180

Coordinate

180

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001243241.1, NP_006272.2

ZINC - World Drugs

STK3_HUMAN

Guide to Pharmacology - Targets

2219

OpenTargets

ENSG00000104375

ENSEMBL

ENSP00000390500, ENST00000523601, ENST00000419617, ENSP00000429744

ZINC - FDA approved

STK3_HUMAN

ZINC - Substances

STK3_HUMAN

ZINC - Biogenic

STK3_HUMAN

ZINC target

Q13188

PRO

Q13188

GlyGen

Q13188

PDB

4L0N, 4OH9, 4HKD, 8A66, 6AR2, 5DH3, 4LG4, 4LGD, 3WWS, 5BRM, 6AO5

ZINC - Investigational

STK3_HUMAN

HPA

ENSG00000104375-STK3

Pharos - Targets

Q13188

ZINC - Predictions - Purchasable

STK3_HUMAN

HMDB Protein

HMDBP01454

Interactors (48)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H4B6 SAV1	2	p-SAV1 [cytosol] (R-HSA-2028276) SAV1 [cytosol] (R-HSA-2028283)	0.957	29
UniProt:P50749 RASF2			0.951	21
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) STK4(327-487) [cytosol] (R-HSA-2028668) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682)	0.914	20
UniProt:Q9H2L5 RASF4			0.905	11
UniProt:Q8WWW0 RASF5			0.892	9
UniProt:Q9NS23-2 RASSF1			0.848	7
UniProt:Q9NS23 RASF1			0.827	9
UniProt:Q86WH2 RASF3			0.788	7
UniProt:Q14BN4 SLMAP			0.766	7
UniProt:Q8WWW0-1 RASSF5			0.753	6
UniProt:Q13188 STK3	4	STK3(1-491) [cytosol] (R-HSA-2028280) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274) STK3(323-491) [cytosol] (R-HSA-2028684) p-T180-STK3(1-322) [cytosol] (R-HSA-2028696)	0.737	13
UniProt:Q9P0L0 VAPA	4	VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [cytosol] (R-HSA-9609920)	0.725	5
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.718	6
UniProt:Q66K74 MAP1S			0.706	5
UniProt:Q7L9L4 MOB1B	2	p-T12,T35-MOB1B [cytosol] (R-HSA-2028643) MOB1B [cytosol] (R-HSA-2028569)	0.691	9
UniProt:Q6ZTQ3 RASF6			0.659	3
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.645	6
UniProt:P46821 MAP1B	1	MAP1B(2-2206) [cytosol] (R-HSA-9836954)	0.643	3
UniProt:Q9H8S9 MOB1A	2	p-T12,T35-MOB1A [cytosol] (R-HSA-2028628) MOB1A [cytosol] (R-HSA-2028568)	0.629	7
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [autophagosome membrane] (R-HSA-5683641)	0.591	5
UniProt:Q99MK9 RASF1			0.564	2
UniProt:Q99259 GAD1	2	PXLP-K405-GAD1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888580) PXLP-K405-GAD1 [plasma membrane] (R-HSA-947477)	0.556	3
UniProt:Q8IZU0 FAM9B			0.556	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:Q8TAD8 SNIP1	1	SNIP1 [nucleoplasm] (R-HSA-3222315)	0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:P0C1Z6-2 TFPT			0.556	3
UniProt:P0C1Z6 TFPT	1	TFPT [nucleoplasm] (R-HSA-5689542)	0.556	3
UniProt:Q53SE7 Q53SE7			0.556	3
UniProt:Q86TA1 MOB3B			0.556	3
UniProt:Q9H814 PHAX	2	PHAX [cytosol] (R-HSA-191804) PHAX [nucleoplasm] (R-HSA-191803)	0.547	2
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [cytosol] (R-HSA-5671757) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [autophagosome membrane] (R-HSA-5683637)	0.544	2
UniProt:Q9BXW4 MAP1LC3C	3	MAP1LC3C [cytosol] (R-HSA-5679223) MAP1LC3C(1-147) [cytosol] (R-HSA-5682653) MAP1LC3C [autophagosome membrane] (R-HSA-5683638)	0.544	2
UniProt:O95166 GABARAP	3	GABARAP [cytosol] (R-HSA-975521) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [autophagosome membrane] (R-HSA-5683634)	0.544	2
UniProt:P60520 GABARAPL2	3	GABARAPL2 [cytosol] (R-HSA-5671758) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [autophagosome membrane] (R-HSA-5683633)	0.544	2
UniProt:Q8N4N8 KIF2B	1	KIF2B [cytosol] (R-HSA-376259)	0.527	3
UniProt:Q9NZV7 ZIM2	1	ZIM2 [nucleoplasm] (R-HSA-974996)	0.527	2
UniProt:O95292 VAPB	2	VAPB [Golgi membrane] (R-HSA-9715115) VAPB [endoplasmic reticulum membrane] (R-HSA-429718)	0.527	4
UniProt:P18509 ADCYAP1	4	ADCYAP1(132-158) [extracellular region] (R-HSA-420144) ADCYAP1(82-129) [extracellular region] (R-HSA-420254) ADCYAP1(132-169) [extracellular region] (R-HSA-420282) ADCYAP1(2-742) [Golgi membrane] (R-HSA-187679)	0.527	2
UniProt:P53350 PLK1	4	PLK1 [cytosol] (R-HSA-164603) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [nucleoplasm] (R-HSA-156720)	0.527	2
UniProt:Q8TAQ5 ZNF420	2	p-S68-ZNF420 [nucleoplasm] (R-HSA-6799095) ZNF420 [nucleoplasm] (R-HSA-1247509)	0.527	2
UniProt:Q13309 SKP2	3	SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [cytosol] (R-HSA-975495)	0.527	2
UniProt:Q9Y3A3 PHOCN			0.483	3
UniProt:Q5VSL9 STRP1			0.483	3
UniProt:Q13033 STRN3			0.483	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	4
UniProt:Q9NRL3 STRN4			0.483	3
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.483	3

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