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FURIN [Golgi membrane]
Stable Identifier
R-HSA-157049
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
Furin
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
CD163 mediating an anti-inflammatory response (Homo sapiens)
FURIN cleaves ADAM17 (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Assembly Of The HIV Virion (Homo sapiens)
Synthesis and processing of ENV and VPU (Homo sapiens)
Cleavage of the viral Env gp160 precursor polyprotein (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Activation of Matrix Metalloproteinases (Homo sapiens)
Activation of MT-MMPs by FURIN (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
Activation of proMMP11 by FURIN (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
FURIN gene transcription is stimulated by SMAD2/SMAD3:SMAD4 (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
FURIN translocates to the plasma membrane (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501) (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Homo sapiens)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Homo sapiens)
Removal of aminoterminal propeptides from gamma-carboxylated proteins (Homo sapiens)
Furin cleaves pro-BGLAP to BGLAP (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
Furin cleaves pro-GAS6 to GAS6 (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
Furin cleaves pro-factor IX to factor IX (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
Furin cleaves pro-factor VII to factor VII (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
Furin cleaves pro-factor X to factor X (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
Furin cleaves pro-protein C to protein C (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
Furin cleaves pro-protein S to protein S (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
Furin cleaves pro-protein Z to protein Z (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
Furin cleaves pro-prothrombin to prothrombin (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Pre-NOTCH Expression and Processing (Homo sapiens)
Pre-NOTCH Processing in Golgi (Homo sapiens)
Fringe-modified Pre-NOTCH is cleaved by FURIN (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
NOTCH precursor cleaved to form mature NOTCH (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
PDGF-AA clevage by Furin (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
PDGF-AB clevage by Furin (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
PDGF-BB clevage by Furin (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Latent TGF-beta-1 is cleaved by FURIN (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
FURIN gene transcription is stimulated by SMAD2/SMAD3:SMAD4 (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
FURIN translocates to the plasma membrane (Homo sapiens)
FURIN [Golgi membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
1629222
Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage
Leduc, R
,
Molloy, S S
,
Thorne, BA
,
Thomas, G
J Biol Chem
1992
External Reference Information
External Reference
UniProt:P09958 FURIN
Gene Names
FURIN, FUR, PACE, PCSK3
Chain
signal peptide:1-26, propeptide:27-107, chain:108-794
Reference Genes
BioGPS Gene:5045 FURIN
COSMIC (genes):FURIN FURIN
CTD Gene:5045 FURIN
dbSNP Gene:5045 FURIN
ENSEMBL:ENSG00000140564 FURIN
HGNC:8568 FURIN
KEGG:hsa:5045 FURIN
Monarch:5045 FURIN
NCBI Gene:5045 FURIN
OMIM:136950 FURIN
UCSC:P09958 FURIN
Reference Transcript
RefSeq:NM_002569.3 FURIN
RefSeq:NM_001289823.1 FURIN
RefSeq:NM_001289824.1 FURIN
Other Identifiers
11716282_s_at
16804942
201945_PM_at
201945_at
35338_at
3608399
3608401
3608402
3608404
3608405
3608406
3608407
3608408
3608409
3608411
3608412
3608413
3608414
3608415
3608416
3608417
3608418
3608419
3608420
3608421
3608422
3608423
3608424
3608425
3608426
3608428
3608429
3608430
3608431
3608432
3608433
3608434
5045
7986092
A_23_P3368
GO:0000139
GO:0001825
GO:0002020
GO:0002862
GO:0003824
GO:0004175
GO:0004252
GO:0004867
GO:0005515
GO:0005576
GO:0005768
GO:0005783
GO:0005794
GO:0005796
GO:0005802
GO:0005886
GO:0006465
GO:0006508
GO:0007179
GO:0008201
GO:0008233
GO:0008236
GO:0009966
GO:0009986
GO:0010008
GO:0016020
GO:0016485
GO:0016486
GO:0016787
GO:0019058
GO:0019081
GO:0019082
GO:0022617
GO:0030140
GO:0030198
GO:0030574
GO:0031410
GO:0031638
GO:0032374
GO:0032804
GO:0032902
GO:0032911
GO:0032940
GO:0034369
GO:0042176
GO:0042277
GO:0043043
GO:0043226
GO:0045121
GO:0046598
GO:0046872
GO:0048406
GO:0051044
GO:0051604
GO:0052548
GO:0070062
GO:0090472
GO:0098772
GO:0140096
GO:0140447
GO:1904399
GO:1990000
HMNXSV003039920
ILMN_1790228
PH_hs_0003807
TC15000870.hg
TC15002368.hg
X17094_at
g4505578_3p_at
Participates
as an input of
FURIN translocates to the plasma membrane (Homo sapiens)
as an output of
FURIN gene transcription is stimulated by SMAD2/SMAD3:SMAD4 (Homo sapiens)
Other forms of this molecule
FURIN [extracellular region]
FURIN [plasma membrane]
FURIN [Golgi lumen]
FURIN [trans-Golgi network membrane]
FURIN [macropinosome membrane]
Inferred To
krp1 [Golgi membrane]
(Schizosaccharomyces pombe)
furin [Golgi membrane]
(Xenopus tropicalis)
Homologues of FURIN [Golgi membrane]
(Plasmodium falciparum)
SUB2 [Golgi membrane]
(Plasmodium falciparum)
Fur1 [Golgi membrane]
(Drosophila melanogaster)
FURIN [Golgi membrane]
(Bos taurus)
FURIN [Golgi membrane]
(Caenorhabditis elegans)
FURIN [Golgi membrane]
(Canis familiaris)
FURIN [Golgi membrane]
(Gallus gallus)
FURIN [Golgi membrane]
(Mus musculus)
FURIN [Golgi membrane]
(Plasmodium falciparum)
FURIN [Golgi membrane]
(Rattus norvegicus)
FURIN [Golgi membrane]
(Saccharomyces cerevisiae)
FURIN [Golgi membrane]
(Sus scrofa)
furina [Golgi membrane]
(Danio rerio)
Cross References
RefSeq
NP_001276753.1
,
NP_001276752.1
,
NP_002560.1
Guide to Pharmacology - Targets
2366
OpenTargets
ENSG00000140564
ENSEMBL
ENSP00000506143
,
ENST00000618099
,
ENSP00000484952
,
ENST00000268171
,
ENSP00000268171
,
ENST00000680053
,
ENSP00000483552
,
ENST00000610579
ZINC - Substances
FURIN_HUMAN
ZINC target
P09958
PRO
P09958
GlyGen
P09958
PDB
7QY1
,
7QXY
,
7QY0
,
7QY2
,
8OYH
,
8B4V
,
8B4X
,
7LCU
,
7O1U
,
7O1W
,
7QXZ
,
8B4W
,
7O20
,
5MIM
,
6YD7
,
5JMO
,
6YD3
,
6YD4
,
6EQX
,
6HLE
,
6HLD
,
6YD2
,
6EQV
,
4Z2A
,
6HLB
,
5JXJ
,
6EQW
,
5JXI
,
6HZD
,
6A8Y
,
7O1Y
,
4OMD
,
5JXG
,
6HZB
,
5JXH
,
6HZC
,
4RYD
,
7O22
,
4OMC
,
6HZA
IntEnz
3.4.21.75
HPA
ENSG00000140564-FURIN
Pharos - Targets
P09958
ZINC - Predictions - Purchasable
FURIN_HUMAN
HMDB Protein
HMDBP07695
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTC2 S
20
S(686-815) [plasma membrane]
(R-COV-9770188)
Spike S2' Fragment [plasma membrane]
(R-COV-9770189)
S1 [plasma membrane]
(R-COV-9769950)
fully glycosylated Spike [plasma membrane]
(R-COV-9733472)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9694796)
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9694459)
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696892)
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696875)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
(R-COV-9696880)
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9766369)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696943)
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696920)
complex N-glycan-PALM-Spike S1 Fragment [virion membrane]
(R-COV-9694638)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9694791)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9694343)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9694745)
fully glycosylated Spike [virion membrane]
(R-COV-9698327)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698330)
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
(R-COV-9769952)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696997)
0.854
5
UniProt:K9N5Q8 SPIKE
0.623
3
UniProt:O14793 MSTN
1
MSTN [extracellular region]
(R-HSA-9625529)
0.623
2
UniProt:P50281 MMP14
4
MMP14 [plasma membrane]
(R-HSA-1442472)
MMP14(21-582) [Golgi lumen]
(R-HSA-1604689)
MMP14 [Golgi lumen]
(R-HSA-1604724)
MMP14 [Golgi membrane]
(R-HSA-9858808)
0.564
3
UniProt:Q9H239 MMP28
0.556
3
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:P05154 SERPINA5
1
SERPINA5 [extracellular region]
(R-HSA-5591085)
0.527
2
UniProt:P55899 FCGRN
0.527
2
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