Reactome | DTX2 [cytosol]

DTX2 [cytosol]

Stable Identifier

R-HSA-1604436

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein deltex-2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q86UW9 DTX2

Gene Names

DTX2, KIAA1528, RNF58

Chain

chain:1-622

Reference Genes

BioGPS Gene:113878 DTX2

COSMIC (genes):DTX2 DTX2

CTD Gene:113878 DTX2

dbSNP Gene:113878 DTX2

ENSEMBL:ENSG00000091073 DTX2

ENSEMBL_homo_sapiens_GENE:ENSG00000091073.20 DTX2

HGNC:15973 DTX2

KEGG Gene (Homo sapiens):113878 DTX2

Monarch:113878 DTX2

NCBI Gene:113878 DTX2

OMIM:613141 DTX2

UCSC:Q86UW9 DTX2

Reference Transcript

Other Identifiers

113878

11740981_a_at

11755938_a_at

17124592

17124594

17124596

215732_3p_s_at

215732_PM_s_at

215732_s_at

3009473

3009474

3009477

3009478

3009481

3009488

3009489

3009490

3009491

3009492

3009502

3009503

3009504

3009507

3009512

3009514

3009516

3009517

3009518

3009519

3009723

3009724

3009725

3009730

3009731

3009733

3009734

3009735

3009736

3009738

3009741

3009744

3009745

3009747

3009752

37977_at

8133736

A_21_P0013244

A_23_P395033

A_33_P3502640

GE85812

GO:0003824

GO:0005515

GO:0005634

GO:0005635

GO:0005654

GO:0005737

GO:0007219

GO:0008270

GO:0016567

GO:0016740

GO:0023052

GO:0031965

GO:0036211

GO:0043226

GO:0046872

GO:0061630

GO:0140096

HMNXSV003029657

Hs.89135.2.S1_3p_a_at

Hs.89135.2.S1_3p_x_at

ILMN_1744129

ILMN_2275098

PH_hs_0027181

TC07003309.hg

Participates

as a candidate of

DTX [cytosol] (Homo sapiens)

Inferred To

Dtx2 [cytosol] (Mus musculus)

Dtx2 [cytosol] (Rattus norvegicus)

dx [cytosol] (Drosophila melanogaster)

DTX2 [cytosol] (Bos taurus)

DTX2 [cytosol] (Canis familiaris)

DTX2 [cytosol] (Gallus gallus)

DTX2 [cytosol] (Sus scrofa)

dtx2 [cytosol] (Danio rerio)

dtx2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_011514075.1, XP_016867215.1, XP_011514074.1, XP_016867214.1, NP_001096066.1, XP_005250188.1, NP_001096065.1, XP_005250189.1, XP_016867213.1, NP_065943.2, XP_011514077.1, NP_001096064.1, XP_016867212.1, XP_011514076.1, XP_016867216.1

OpenTargets

ENSG00000091073

IntEnz

2.3.2.27

GeneCards

Q86UW9

HPA

ENSG00000091073-DTX2

Ensembl

ENSP00000322885, ENST00000446820, ENST00000413936, ENST00000430490, ENSP00000390218, ENSP00000411986, ENST00000324432, ENSG00000091073, ENSP00000392545

PRO

Q86UW9

Pharos - Targets

Q86UW9

PDB

6IR0, 6Y2X, 6Y22, 6Y3J

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51668 UBE2D1	3	UBE2D1 [cytosol] (R-HSA-174236) UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160)	0.781	7
UniProt:Q8IVS8 GLYCTK	1	GLYCTK [cytosol] (R-HSA-6799244)	0.718	6
UniProt:P61077 UBE2D3	3	UBE2D3 [nucleoplasm] (R-HSA-205341) UBE2D3 [cytosol] (R-HSA-934630) Ub-C85-UBE2D3 [cytosol] (R-HSA-8864191)	0.718	9
UniProt:Q9HBZ2 ARNT2	1	ARNT2 [nucleoplasm] (R-HSA-8936838)	0.666	4
UniProt:P14652 HOXB2	1	HOXB2 [nucleoplasm] (R-HSA-5617487)	0.556	3
UniProt:P28070 PSMB4	4	PSMB4(1-45) [cytosol] (R-HSA-9908122) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4 [nucleoplasm] (R-HSA-174343) PSMB4 [cytosol] (R-HSA-68750)	0.556	3
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) SUMO1 [nucleoplasm] (R-HSA-877304) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.556	3
UniProt:Q96RU7 TRIB3	3	TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [cytosol] (R-HSA-162411) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.556	3
UniProt:Q02548 PAX5	1	PAX5 [nucleoplasm] (R-HSA-158583)	0.556	3
UniProt:Q15436 SEC23A	4	p-S738,T744 SEC23A [cytosol] (R-HSA-5685740) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) SEC23A [cytosol] (R-HSA-203972) SEC23A [endoplasmic reticulum membrane] (R-HSA-203976)	0.556	3
UniProt:O43521 BCL2L11	7	BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674) BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (R-HSA-6802276) BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol] (R-HSA-6802519) p-S69-BCL2L11 [cytosol] (R-HSA-2976671) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-BCL2L11 [cytosol] (R-HSA-140525) BCL2L11 [cytosol] (R-HSA-2976673)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	6
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.556	6
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.556	3

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