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What is Reactome ?
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PSMB4 [cytosol]
Stable Identifier
R-HSA-68750
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Proteasome subunit beta-7, Proteasome subunit beta-7
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
p53-Dependent G1 DNA Damage Response (Homo sapiens)
Stabilization of p53 (Homo sapiens)
Autodegradation of the E3 ubiquitin ligase COP1 (Homo sapiens)
Proteasome mediated degradation of COP1 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
p53-Independent G1/S DNA damage checkpoint (Homo sapiens)
p53-Independent DNA Damage Response (Homo sapiens)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Homo sapiens)
Proteolytic degradation of ubiquitinated-Cdc25A (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
Degradation of multiubiquitinated Securin (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Homo sapiens)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Proteasome-mediated degradation of PolyUb-FBXL7 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
The role of GTSE1 in G2/M progression after G2 checkpoint (Homo sapiens)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
Degradation of multiubiquitinated cell cycle proteins (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of Securin (Homo sapiens)
Degradation of multiubiquitinated Securin (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Homo sapiens)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Homo sapiens)
Degradation multiubiquitinated Cyclin A (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
SCF-beta-TrCP mediated degradation of Emi1 (Homo sapiens)
SCF-mediated degradation of Emi1 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Ubiquitinated Cdc6 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Ubiquitinated Orc1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Ubiquitin-dependent degradation of Cyclin D (Homo sapiens)
Proteasome mediated degradation of Cyclin D1 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
26S proteasome degrades Ub-NFE2L2 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
ub UBXN7 is degraded by the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Proteasome proteolyzes ub-HIF-alpha (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Ubiquitinated Cdc6 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Ubiquitinated Orc1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
Proteasome degrades ubiquitinated ROBO3.1 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Hh mutants abrogate ligand secretion (Homo sapiens)
Hh mutants are degraded by ERAD (Homo sapiens)
processing defective Hh variants are degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
ABC transporter disorders (Homo sapiens)
Defective CFTR causes cystic fibrosis (Homo sapiens)
CFTR F508del is degraded by the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
Vif-mediated degradation of APOBEC3G (Homo sapiens)
Proteosome-mediated degradation of APOBEC3G (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Vpu mediated degradation of CD4 (Homo sapiens)
Degradation of ubiquitinated CD4 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
Proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
Cross-presentation of soluble exogenous antigens (endosomes) (Homo sapiens)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
Proteasomal cleavage of substrate (26S proteasome catalyst) (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Proteasomal cleavage of substrate (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
Ubiquitinated IkB is degraded (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
26Sproteasome degrades K48polyUb-NIK (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
NIK-->noncanonical NF-kB signaling (Homo sapiens)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of polyamines (Homo sapiens)
Regulation of ornithine decarboxylase (ODC) (Homo sapiens)
26S proteosome degrades ODC holoenzyme complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Homo sapiens)
AUF1:mRNA complex is destroyed (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
UCH proteinases (Homo sapiens)
ADRM1 binds 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
ADRM1:26S proteaseome binds UCHL5 (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
ADRM1:26S proteasome:UCHL5 [cytosol] (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
ADRM1:26S proteaseome binds USP14 (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
ADRM1:26S proteasome:USP14 [cytosol] (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Neddylation (Homo sapiens)
26S proteasome degrades HIFalpha (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
26S proteasome degrades Ub-NFE2L2 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
ub UBXN7 is degraded by the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Proteasome assembly (Homo sapiens)
Formation of the 26S proteasome (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Formation of the PA28-alpha-beta-20S proteasome (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
PA28-alpha-beta-20S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Formation of the PA28gamma-20S proteasome (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
PA28gamma-20S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Formation of the immunoproteasome (Homo sapiens)
20S immunoproteasome core particle [cytosol] (Homo sapiens)
20S CP immunoproteasome inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Immunoproteasome [cytosol] (Homo sapiens)
20S immunoproteasome core particle [cytosol] (Homo sapiens)
20S CP immunoproteasome inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Formation of the spermatoproteasome (Homo sapiens)
20S core particle of spermatoproteasome [cytosol] (Homo sapiens)
Mature half-spermatoproteasome [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Spermatoproteasome [cytosol] (Homo sapiens)
20S core particle of spermatoproteasome [cytosol] (Homo sapiens)
Mature half-spermatoproteasome [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Maturation of the 20S immunoproteasome core particle (Homo sapiens)
20S immunoproteasome core particle [cytosol] (Homo sapiens)
20S CP immunoproteasome inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Maturation of the 20S thymoproteasome core particle (Homo sapiens)
20S thymoproteasome core particle [cytosol] (Homo sapiens)
20S CP thymoproteasome inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Maturation of the canonical 20S core particle (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Maturation of the preholospermatoproteasome (Homo sapiens)
20S core particle of spermatoproteasome [cytosol] (Homo sapiens)
Mature half-spermatoproteasome [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
PSMF1 binds the 20S core particle (Homo sapiens)
20S CP:PSMF1 [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN stability and activity (Homo sapiens)
Proteasome degrades polyubiquitinated PTEN (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Regulation of RAS by GAPs (Homo sapiens)
NF1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
MAPK6 is degraded by the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
Degradation of GLI1 by the proteasome (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Degradation of GLI2 by the proteasome (Homo sapiens)
GLI2 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
GLI3 is processed to GLI3R by the proteasome (Homo sapiens)
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
ub-GLI is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Hedgehog ligand biogenesis (Homo sapiens)
Hh C-terminal fragments are degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
Asymmetric localization of PCP proteins (Homo sapiens)
PRICKLE1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
Degradation of ubiquitinated beta catenin by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Degradation of AXIN (Homo sapiens)
Ub-RibC-AXIN is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Ubiquitinated AXIN is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Degradation of DVL (Homo sapiens)
Ubiquitinated DVL is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Ubiquitinated DVL1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
misfolded CFTR is degraded by the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
20S core particle [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
PSMB4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P28070 PSMB4
Gene Names
PSMB4, PROS26
Chain
propeptide:1-45, chain:46-264
Reference Genes
BioGPS Gene:5692 PSMB4
COSMIC (genes):PSMB4 PSMB4
CTD Gene:5692 PSMB4
dbSNP Gene:5692 PSMB4
ENSEMBL:ENSG00000159377 PSMB4
ENSEMBL_homo_sapiens_GENE:ENSG00000159377.11 PSMB4
HGNC:9541 PSMB4
KEGG Gene (Homo sapiens):5692 PSMB4
Monarch:5692 PSMB4
NCBI Gene:5692 PSMB4
OMIM:602177 PSMB4
UCSC:P28070 PSMB4
Reference Transcript
RefSeq:NM_002796.2 PSMB4
Other Identifiers
11715407_s_at
11715408_x_at
11754271_a_at
1311_at
16670850
202243_PM_s_at
202243_s_at
202244_PM_at
202244_at
2358907
2358908
2358909
2358911
2358912
2358913
2358914
2358916
2358919
2358921
2358923
33154_at
5692
7905395
A_23_P761
D26600_at
GE81194
GO:0000502
GO:0001530
GO:0002376
GO:0002862
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005815
GO:0005829
GO:0005839
GO:0005856
GO:0005929
GO:0006954
GO:0008289
GO:0010498
GO:0019774
GO:0030163
GO:0036064
GO:0043161
GO:0043226
GO:0051603
GO:0070062
HMNXSV003013847
ILMN_1737862
PH_hs_0004994
g4506198_3p_at
Participates
as a component of
20S CP thymoproteasome inner ring [cytosol] (Homo sapiens)
20S CP immunoproteasome inner ring [cytosol] (Homo sapiens)
20S CP inner ring [cytosol] (Homo sapiens)
Other forms of this molecule
PSMB4(1-45) [cytosol]
pro-PSMB4 [cytosol]
PSMB4 [nucleoplasm]
Inferred To
psmB4-1 [cytosol]
(Dictyostelium discoideum)
PRE4 [cytosol]
(Saccharomyces cerevisiae)
Ghost homologue of PSMB4 [cytosol]
(Canis familiaris)
Ghost homologue of PSMB4 [cytosol]
(Danio rerio)
Ghost homologue of PSMB4 [cytosol]
(Sus scrofa)
Ghost homologue of PSMB4 [cytosol]
(Xenopus tropicalis)
Prosbeta7 [cytosol]
(Drosophila melanogaster)
bPSMB4 [cytosol]
(Bos taurus)
PSMB4 [cytosol]
(Gallus gallus)
PSMB4 [cytosol]
(Plasmodium falciparum)
PSMB4 [cytosol]
(Schizosaccharomyces pombe)
Psmb4 [cytosol]
(Mus musculus)
Psmb4 [cytosol]
(Rattus norvegicus)
pbs-7 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_002787.2
OpenTargets
ENSG00000159377
GeneCards
P28070
HPA
ENSG00000159377-PSMB4
Ensembl
ENSP00000290541
,
ENST00000290541
,
ENSG00000159377
PRO
P28070
Pharos - Targets
P28070
PDB
8QYN
,
5LE5
,
7NAN
,
7PG9
,
6MSH
,
8UD9
,
6RGQ
,
6REY
,
7W3A
,
6MSG
,
5LN3
,
7NAP
,
5T0C
,
8CVT
,
6WJD
,
5M32
,
7NAQ
,
8CVS
,
7W3C
,
5T0G
,
7W3F
,
8CVR
,
5GJQ
,
7QYA
,
5VFO
,
5T0H
,
7W3H
,
5LEX
,
7QY7
,
7W3I
,
5T0I
,
6R70
,
7QXN
,
5VFR
,
6MSB
,
6AVO
,
7W38
,
6KWY
,
6E5B
,
5VFS
,
5LF3
,
7W3B
,
5VFU
,
7AWE
,
6XMJ
,
4R67
,
7QXU
,
5L4G
,
5VFT
,
8BZL
,
7QXP
,
7NHT
,
7W3M
,
5LF4
,
5LF6
,
6MSJ
,
8QYS
,
6MSK
,
7QXX
,
7LXV
,
7NAO
,
8QYO
,
5LF7
,
7QXW
,
8CXB
,
7W37
,
7V5G
,
6WJN
,
5T0J
,
5VFQ
,
5GJR
,
7W3G
,
7B12
,
5VFP
,
5LEY
,
5A0Q
,
5LF0
,
4R3O
,
7W3J
,
5LF1
,
6MSE
,
7QYB
,
7V5M
,
7W39
,
6MSD
,
7W3K
,
5LEZ
Interactors (54)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P25786 PSMA1
2
PSMA1 [nucleoplasm]
(R-HSA-174333)
PSMA1 [cytosol]
(R-HSA-68724)
0.862
12
UniProt:P20618 PSMB1
7
PSMB1(1-28) [cytosol]
(R-HSA-9908143)
pro-PSMB1 [cytosol]
(R-HSA-9908139)
PSMB1 [secretory granule lumen]
(R-HSA-6803287)
PSMB1 [extracellular region]
(R-HSA-6806477)
PSMB1 [ficolin-1-rich granule lumen]
(R-HSA-6803340)
PSMB1 [nucleoplasm]
(R-HSA-174347)
PSMB1 [cytosol]
(R-HSA-68738)
0.8
9
UniProt:P25787 PSMA2
5
PSMA2 [secretory granule lumen]
(R-HSA-6803329)
PSMA2 [extracellular region]
(R-HSA-6806506)
PSMA2 [ficolin-1-rich granule lumen]
(R-HSA-6803285)
PSMA2 [nucleoplasm]
(R-HSA-174345)
PSMA2 [cytosol]
(R-HSA-68726)
0.788
8
UniProt:O14818 PSMA7
2
PSMA7 [nucleoplasm]
(R-HSA-174351)
PSMA7 [cytosol]
(R-HSA-68736)
0.725
5
UniProt:P49721 PSMB2
2
PSMB2 [nucleoplasm]
(R-HSA-174335)
PSMB2 [cytosol]
(R-HSA-68744)
0.725
5
UniProt:Q15797 SMAD1
4
Ub-SMAD1 [cytosol]
(R-HSA-6782768)
SMAD1 [cytosol]
(R-HSA-201468)
p-S463,S465-SMAD1 [cytosol]
(R-HSA-201464)
p-S463,S465-SMAD1 [nucleoplasm]
(R-HSA-201483)
0.666
4
UniProt:P25788 PSMA3
2
PSMA3 [nucleoplasm]
(R-HSA-174323)
PSMA3 [cytosol]
(R-HSA-68728)
0.666
5
UniProt:Q99436 PSMB7
7
PSMB7(1-43) [cytosol]
(R-HSA-9908129)
pro-PSMB7 [cytosol]
(R-HSA-9908145)
PSMB7 [secretory granule lumen]
(R-HSA-6803279)
PSMB7 [extracellular region]
(R-HSA-6806449)
PSMB7 [ficolin-1-rich granule lumen]
(R-HSA-6803312)
PSMB7 [nucleoplasm]
(R-HSA-174331)
PSMB7 [cytosol]
(R-HSA-68759)
0.659
4
UniProt:Q9Y244 POMP
1
POMP [cytosol]
(R-HSA-9908067)
0.659
4
UniProt:P28074 PSMB5
4
PSMB5(1-59) [cytosol]
(R-HSA-9908134)
pro-PSMB5 [cytosol]
(R-HSA-9908135)
PSMB5 [nucleoplasm]
(R-HSA-174344)
PSMB5 [cytosol]
(R-HSA-68753)
0.659
4
UniProt:Q06323 PSME1
1
PSME1 [cytosol]
(R-HSA-68812)
0.643
4
UniProt:P28066 PSMA5
5
PSMA5 [secretory granule lumen]
(R-HSA-6803316)
PSMA5 [extracellular region]
(R-HSA-6806459)
PSMA5 [ficolin-1-rich granule lumen]
(R-HSA-6803328)
PSMA5 [nucleoplasm]
(R-HSA-174340)
PSMA5 [cytosol]
(R-HSA-68732)
0.643
5
UniProt:P60900 PSMA6
2
PSMA6 [nucleoplasm]
(R-HSA-174314)
PSMA6 [cytosol]
(R-HSA-68734)
0.643
4
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.643
4
UniProt:Q14997 PSME4
1
PSME4 [cytosol]
(R-HSA-947606)
0.643
4
UniProt:P62333 PSMC6
2
PSMC6 [nucleoplasm]
(R-HSA-174319)
PSMC6 [cytosol]
(R-HSA-68783)
0.638
3
UniProt:Q9NX04 AIRIM
0.556
3
UniProt:Q9Y3C5 RNF11
0.556
3
UniProt:Q8TDC0 MYOZ3
0.556
3
UniProt:Q7Z4N8 P4HA3
1
P4HA3 [endoplasmic reticulum lumen]
(R-HSA-2980915)
0.556
3
UniProt:Q7Z6R9 TFAP2D
1
TFAP2D [nucleoplasm]
(R-HSA-5626817)
0.556
3
UniProt:Q99471 PFDN5
1
PFDN5 [cytosol]
(R-HSA-379548)
0.556
3
UniProt:Q9NZD8 SPG21
0.556
3
UniProt:Q3LI72 KRTAP19-5
1
KRTAP19-5 [cytosol]
(R-HSA-6810300)
0.556
3
UniProt:Q96M29 TEKT5
0.556
3
UniProt:Q99697-2 PITX2
0.556
3
UniProt:Q08117-2 TLE5
0.556
5
UniProt:Q13148 TADBP
0.556
3
UniProt:Q5JUK2 SOLH1
0.556
3
UniProt:Q2TAC2-2 CCDC57
0.556
3
UniProt:Q9H0R8 GABARAPL1
3
GABARAPL1 [autophagosome membrane]
(R-HSA-5683637)
GABARAPL1(1-117) [cytosol]
(R-HSA-5682659)
GABARAPL1 [cytosol]
(R-HSA-5671757)
0.556
3
UniProt:O60260-5 PRKN
0.556
3
UniProt:Q86UW9 DTX2
1
DTX2 [cytosol]
(R-HSA-1604436)
0.556
3
UniProt:A1L4K1 FSD2
0.556
3
UniProt:Q9NZN8 CNOT2
1
CNOT2 [cytosol]
(R-HSA-429902)
0.556
3
UniProt:P54253 ATX1
0.556
6
UniProt:O75360 PROP1
0.556
3
UniProt:Q63ZY3 KANK2
0.556
3
UniProt:Q9H987-2 SYNPO2L
0.556
3
UniProt:P28676 GCA
2
GCA [extracellular region]
(R-HSA-6806174)
GCA [azurophil granule lumen]
(R-HSA-6799167)
0.556
3
UniProt:Q9Y5R4 HEMK1
0.556
3
UniProt:Q16512 PKN1
3
p-T774-PKN1 [nucleoplasm]
(R-HSA-5625721)
p-T774-PKN1 [cytosol]
(R-HSA-5623651)
PKN1 [cytosol]
(R-HSA-5623613)
0.556
3
UniProt:P41182 BCL6
1
BCL6 [nucleoplasm]
(R-HSA-5223066)
0.556
3
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
UniProt:Q92530 PSMF1
1
PSMF1 [cytosol]
(R-HSA-68818)
0.527
3
UniProt:Q9Y3I1 FBXO7
1
FBXO7 [cytosol]
(R-HSA-8862627)
0.527
3
UniProt:Q969U7 PSMG2
1
PSMG2 [cytosol]
(R-HSA-9908053)
0.527
3
UniProt:P49720 PSMB3
2
PSMB3 [nucleoplasm]
(R-HSA-174341)
PSMB3 [cytosol]
(R-HSA-68747)
0.527
4
UniProt:Q9UL46 PSME2
2
PSME2 [nucleoplasm]
(R-HSA-174350)
PSME2 [cytosol]
(R-HSA-68814)
0.527
3
UniProt:P25789 PSMA4
2
PSMA4 [nucleoplasm]
(R-HSA-174324)
PSMA4 [cytosol]
(R-HSA-68730)
0.527
3
UniProt:P28072 PSMB6
4
PSMB6(1-34) [cytosol]
(R-HSA-9908141)
pro-PSMB6 [cytosol]
(R-HSA-9908130)
PSMB6 [nucleoplasm]
(R-HSA-174342)
PSMB6 [cytosol]
(R-HSA-68756)
0.527
3
UniProt:O43242 PSMD3
5
PSMD3 [secretory granule lumen]
(R-HSA-6800873)
PSMD3 [extracellular region]
(R-HSA-6806443)
PSMD3 [ficolin-1-rich granule lumen]
(R-HSA-6800408)
PSMD3 [nucleoplasm]
(R-HSA-174328)
PSMD3 [cytosol]
(R-HSA-68798)
0.527
2
UniProt:P28065 PSMB9
3
PSMB9(1-20) [cytosol]
(R-HSA-9908132)
PSMB9 [cytosol]
(R-HSA-68765)
pro-PSMB9 [cytosol]
(R-HSA-9908136)
0.527
4
UniProt:O00231 PSMD11
5
PSMD11 [secretory granule lumen]
(R-HSA-6800943)
PSMD11 [extracellular region]
(R-HSA-6806441)
PSMD11 [ficolin-1-rich granule lumen]
(R-HSA-6800436)
PSMD11 [nucleoplasm]
(R-HSA-174327)
PSMD11 [cytosol]
(R-HSA-68790)
0.527
2
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