Reactome | lysyl-G97-SUMO1 [viral capsid]

lysyl-G97-SUMO1 [viral capsid]

Stable Identifier

R-HSA-9762386

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

viral capsid

Synonyms

Small ubiquitin-related modifier 1, SUMO1_HUMAN

Icon

External Reference Information

External Reference

UniProt:P63165 SUMO1

Gene Names

SUMO1, SMT3C, SMT3H3, UBL1, OK/SW-cl.43

Chain

initiator methionine:, chain:2-97, propeptide:98-101

Reference Genes

BioGPS Gene:7341 SUMO1

COSMIC (genes):SUMO1 SUMO1

CTD Gene:7341 SUMO1

dbSNP Gene:7341 SUMO1

ENSEMBL:ENSG00000116030 SUMO1

ENSEMBL_homo_sapiens_GENE:ENSG00000116030.17 SUMO1

HGNC:12502 SUMO1

KEGG Gene (Homo sapiens):7341 SUMO1

Monarch:7341 SUMO1

NCBI Gene:7341 SUMO1

OMIM:601912 SUMO1

UCSC:P63165 SUMO1

Reference Transcript

Other Identifiers

11724205_x_at

11740939_x_at

11744193_x_at

11746828_x_at

11753479_x_at

11763232_x_at

155_s_at

208761_PM_s_at

208761_s_at

208762_PM_at

208762_at

211069_PM_s_at

211069_s_at

2363075

2595254

2595255

2595256

2595257

2595258

2595259

2595260

2595261

2595262

2595264

2595265

2595266

2595274

3838378

457_s_at

7341

8058335

8180373

A_24_P319354

A_33_P3318459

A_33_P3318465

GE59489

GE81266

GO:0003723

GO:0005515

GO:0005634

GO:0005635

GO:0005643

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005886

GO:0006281

GO:0006351

GO:0006355

GO:0006886

GO:0006913

GO:0008076

GO:0008134

GO:0010621

GO:0015459

GO:0016020

GO:0016604

GO:0016605

GO:0016607

GO:0016925

GO:0019899

GO:0030163

GO:0031334

GO:0031386

GO:0031625

GO:0031965

GO:0032436

GO:0032880

GO:0034605

GO:0036211

GO:0042308

GO:0043226

GO:0043392

GO:0043433

GO:0044388

GO:0044389

GO:0045759

GO:0045892

GO:0048856

GO:0050821

GO:0055085

GO:0060021

GO:0065003

GO:0071276

GO:0097165

GO:0098772

GO:1902260

GO:1990381

HMNXSV003004183

Hs.302113.0.S1_3p_s_at

ILMN_1790105

ILMN_2379835

PH_hs_0029007

TC02002682.hg

U61397_s_at

U67122_s_at

X99586_s_at

g1762972_3p_s_at

g1769601_3p_at

Participates

as a repeated unit of

monoSUMO1 [viral capsid] (Homo sapiens)

Other forms of this molecule

lysyl-G97-SUMO1 [plasma membrane]

lysyl-G97-SUMO1 [nucleolus]

UBE2I-G97-SUMO1 [cytosol]

lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]

lysyl-G97-SUMO1 [cytosol]

UBE2I-G97-SUMO1 [nucleoplasm]

UBA2-G97-SUMO1 [nucleoplasm]

SUMO1 [nucleoplasm]

SUMO1(2-101) [nucleoplasm]

lysyl-G97-SUMO1 [nucleoplasm]

Modified Residues

Name

glycine amide at 97

Coordinate

PsiMod Name

glycine amide

PsiMod Definition

A protein modification that effectively converts a glycine residue to glycine amide.

Cross References

RefSeq

NP_001005782.1, NP_001005781.1, NP_003343.1

OpenTargets

ENSG00000116030

GeneCards

P63165

HPA

ENSG00000116030-SUMO1

Ensembl

ENST00000392246, ENSG00000116030, ENSP00000376076, ENST00000392245, ENST00000392244, ENSP00000376075, ENSP00000376077

PRO

P63165

Pharos - Targets

P63165

Orphanet

16822

PDB

1A5R, 6JXV, 1WYW, 5GHD, 6K5T, 6UYR, 8DJI, 1Y8R, 6UYQ, 3KYC, 3RZW, 2N1V, 3KYD, 6XOG, 1TGZ, 5B7A, 2IY0, 6V7Q, 6XOI, 2IO2, 6TRW, 6V7R, 2PE6, 1Z5S, 2N1A, 6JXU, 6UYO, 2BF8, 6V7S, 5ELJ, 3UIP, 2UYZ, 6UYP, 5AEK, 4WJO, 6J4I, 4WJN, 6EOP, 6EOT, 4WJP, 6UYS, 2KQS, 4WJQ, 6V7P, 6UYT, 2IY1, 6UYV, 2ASQ, 2VRR, 6UYU, 6UYX, 8ODR, 2LAS, 2G4D, 6XOH, 8DJH, 6WW3, 6UYY, 6UYZ, 2MW5

Interactors (79)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46060 RANGAP1	3	RANGAP1 [nuclear envelope] (R-HSA-167661) monoSUMO1-K524-RANGAP1 [nuclear envelope] (R-HSA-3000416) RANGAP1 [cytosol] (R-HSA-376255)	0.962	14
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481)	0.954	15
UniProt:Q9P0U3 SENP1	2	SENP1 [cytosol] (R-HSA-9715128) SENP1 [nucleoplasm] (R-HSA-2984299)	0.87	12
UniProt:Q9UBT2 UBA2	4	SUMO3-C173-UBA2 [nucleoplasm] (R-HSA-3730623) SUMO2-C173-UBA2 [nucleoplasm] (R-HSA-3730612) SUMO1-C173-UBA2 [nucleoplasm] (R-HSA-3730628) UBA2 [nucleoplasm] (R-HSA-947696)	0.85	9
UniProt:P29590 PML	5	polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) PML [nucleoplasm] (R-HSA-1031706) PML [cytosol] (R-HSA-5624327)	0.832	6
UniProt:Q96B23 ARK2N			0.788	7
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.783	7
UniProt:O75928 PIAS2	1	PIAS2 [nucleoplasm] (R-HSA-2993787)	0.782	8
UniProt:P23497 SP100	3	polySUMO2-K297-SP100 [nucleoplasm] (R-HSA-3000454) monoSUMO1-K297-SP100 [nucleoplasm] (R-HSA-3000382) SP100 [nucleoplasm] (R-HSA-1031705)	0.764	6
UniProt:Q9UBE0 SAE1	1	SAE1 [nucleoplasm] (R-HSA-947697)	0.734	4
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.722	3
UniProt:Q9Y4B4 ARIP4			0.718	6
UniProt:Q7KZS0 Q7KZS0			0.718	6
UniProt:Q6PEW1 ZCH12			0.718	6
UniProt:Q9HCK0 ZBT26			0.718	8
UniProt:P15336 ATF2	2	ATF2 [nucleoplasm] (R-HSA-450336) p-T69,T71-ATF2 [nucleoplasm] (R-HSA-450243)	0.718	6
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.718	6
UniProt:Q16665 HIF1A	7	HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.688	4
UniProt:Q13569 TDG	3	polySUMO2,3-K330-TDG [nucleoplasm] (R-HSA-4551628) monoSUMO1-K330-TDG [nucleoplasm] (R-HSA-4551718) TDG [nucleoplasm] (R-HSA-65812)	0.667	3
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.666	4
UniProt:P19419 ELK1	2	ELK1 [nucleoplasm] (R-HSA-3009346) p-4S,T336-ELK1 [nucleoplasm] (R-HSA-3009350)	0.656	5
UniProt:Q9HC62 SENP2	1	SENP2 [nucleoplasm] (R-HSA-2984298)	0.623	2
UniProt:Q5W0Q7 USPL1			0.611	5
UniProt:O00257 CBX4	2	monoSUMO1-K494-CBX4 [nucleoplasm] (R-HSA-4551626) CBX4 [nucleoplasm] (R-HSA-389118)	0.602	4
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.602	3
UniProt:P10275 AR	4	PolyUb-AR [nucleoplasm] (R-HSA-6782984) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082)	0.602	7
UniProt:P17676-1 CEBPB			0.599	5
UniProt:Q9UBC3 DNMT3B	2	SUMO1-K-DNMT3B [nucleoplasm] (R-HSA-4655334) DNMT3B [nucleoplasm] (R-HSA-212316)	0.59	4
UniProt:P51608 MECP2			0.564	2
UniProt:Q8TAD8 SNIP1	1	SNIP1 [nucleoplasm] (R-HSA-3222315)	0.564	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.564	3
UniProt:Q9ERU9 Ranbp2	5	Ranbp2 [nuclear envelope] (R-MMU-4551720) Ranbp2 [nuclear envelope] (R-MMU-4551599) Ranbp2 [nuclear envelope] (R-MMU-5228524) Ranbp2 [nuclear envelope] (R-MMU-2993756) Ranbp2 [cytosol] (R-MMU-157703)	0.564	2
UniProt:Q9BPY3 F118B			0.556	3
UniProt:Q53SE7 Q53SE7			0.556	3
UniProt:Q59GP6 Q59GP6			0.556	3
UniProt:Q12800 TFCP2			0.556	3
UniProt:Q15916 ZBTB6			0.556	3
UniProt:Q9UJ78 ZMYM5			0.556	3
UniProt:A0A0S2Z4M1 A0A0S2Z4M1			0.556	6
UniProt:Q9Y2F9 BTBD3			0.556	3
UniProt:A0A0S2Z3N6 A0A0S2Z3N6			0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:Q8N3Z6 ZCHC7			0.556	3
UniProt:Q8NDC0 MISSL			0.556	3
UniProt:Q9BQY4 RHXF2			0.556	3
UniProt:P23497-2 SP100			0.556	3
UniProt:Q86UW9 DTX2	1	DTX2 [cytosol] (R-HSA-1604436)	0.556	3
UniProt:O15169 AXIN1	11	AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) RibC-AXIN1 [cytosol] (R-HSA-3640841) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) AXIN1 [cytosol] (R-HSA-195249)	0.556	3
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.556	3
UniProt:Q8N680 ZBTB2			0.556	3
UniProt:O00463 TRAF5			0.556	3
UniProt:O75360 PROP1			0.556	3
UniProt:Q96MM3 ZFP42			0.556	3
UniProt:Q05D60 DEUP1			0.556	3
UniProt:O95073 FSBP			0.556	3
UniProt:G2XKQ0 SUMO5			0.556	3
UniProt:Q9BUZ4 TRAF4			0.556	3
IntAct:EBI-22344578 CCSB ORF ID			0.556	3
UniProt:Q8TES7-6 FBF1			0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:Q9H257 CARD9	3	CARD9 [cytosol] (R-HSA-561194) CARD9 [plasma membrane] (R-HSA-5607662) p-T231-CARD9 [plasma membrane] (R-HSA-5607623)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:P10276 RARA	3	SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.556	5
UniProt:Q8WWZ3 EDARADD	1	EDARADD [cytosol] (R-HSA-5675659)	0.556	5
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q02078-1 MEF2A			0.544	3
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.544	2
UniProt:P10914 IRF1	2	IRF1 [nucleoplasm] (R-HSA-983456) IRF1 [cytosol] (R-HSA-1015686)	0.544	2
UniProt:Q9H2X6 HIPK2	3	p-HIPK2 [nucleoplasm] (R-HSA-6799375) HIPK2 [nucleoplasm] (R-HSA-3215222) monoSUMO1-K32-HIPK2 [nucleoplasm] (R-HSA-4090405)	0.544	2
UniProt:P10242 MYB	1	MYB [nucleoplasm] (R-HSA-992697)	0.544	3
UniProt:Q12888 TP53BP1	3	monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) TP53BP1 [nucleoplasm] (R-HSA-61175)	0.536	2
UniProt:Q14974 KPNB1	5	KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [cytosol] (R-HSA-180733)	0.527	2
UniProt:P06748-1 NPM1			0.524	3
UniProt:Q9UIS9 MBD1	2	monoSUMO1-K499,K538-MBD1 [nucleoplasm] (R-HSA-4090331) MBD1 [nucleoplasm] (R-HSA-417134)	0.524	3
UniProt:Q01826 SATB1	5	polySUMO2,3-K744-SATB1 [nucleoplasm] (R-HSA-4615978) monoSUMO1-K744-SATB1 [nucleoplasm] (R-HSA-4615954) SATB1(255-763) [nucleoplasm] (R-HSA-352264) SATB1(1-254) [nucleoplasm] (R-HSA-352269) SATB1 [nucleoplasm] (R-HSA-201593)	0.508	2
UniProt:O00180 KCNK1	1	KCNK1 [plasma membrane] (R-HSA-1296345)	0.506	3
UniProt:O43290 SART1	1	SART1 [nucleoplasm] (R-HSA-4615999)	0.499	2
UniProt:P0C206 REX			0.488	2

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