Reactome | GNA13 [plasma membrane]

GNA13 [plasma membrane]

Stable Identifier

R-HSA-167451

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G protein alpha 13

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Signal amplification (Homo sapiens)
    - Thromboxane signalling through TP receptor (Homo sapiens)
      - Activated TP receptor binds G-protein G13 (Homo sapiens)
        
        Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (13):GDP [plasma membrane] (Homo sapiens)
        
        GNA13 [plasma membrane] (Homo sapiens)
        
        TP receptor:Thromboxane A2:G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (13):GDP [plasma membrane] (Homo sapiens)
        
        GNA13 [plasma membrane] (Homo sapiens)
      - Dissociation of the TP:G13 complex (Homo sapiens)
        
        G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
        
        GNA13 [plasma membrane] (Homo sapiens)
        
        TP receptor:Thromboxane A2:G-protein G13 (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein G13 (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
        
        GNA13 [plasma membrane] (Homo sapiens)
      - G13 activation by TP receptor (Homo sapiens)
        
        TP receptor:Thromboxane A2:G-protein G13 (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein G13 (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
        
        GNA13 [plasma membrane] (Homo sapiens)
        
        TP receptor:Thromboxane A2:G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (13):GDP [plasma membrane] (Homo sapiens)
        
        GNA13 [plasma membrane] (Homo sapiens)
  - Thrombin signalling through proteinase activated receptors (PARs) (Homo sapiens)
    - Thrombin-activated PARs activate G12/13 (Homo sapiens)
      - Thrombin activated PAR:G12/13 (active) [plasma membrane] (Homo sapiens)
        
        G-protein G12/G13 (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein G13 (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
        
        GNA13 [plasma membrane] (Homo sapiens)
      - Thrombin activated PAR:G12/13 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein G12/G13 (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (13):GDP [plasma membrane] (Homo sapiens)
        
        GNA13 [plasma membrane] (Homo sapiens)
    - Thrombin-activated PARs binds G-protein G12/13 (Homo sapiens)
      - G-protein G12/G13 (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (13):GDP [plasma membrane] (Homo sapiens)
        
        GNA13 [plasma membrane] (Homo sapiens)
      - Thrombin activated PAR:G12/13 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein G12/G13 (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (13):GDP [plasma membrane] (Homo sapiens)
        
        GNA13 [plasma membrane] (Homo sapiens)
    - Thrombin-activated PARs:G12/13 (active) dissociate (Homo sapiens)
      - G-protein alpha (12/13):GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
        
        GNA13 [plasma membrane] (Homo sapiens)
      - Thrombin activated PAR:G12/13 (active) [plasma membrane] (Homo sapiens)
        
        G-protein G12/G13 (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein G13 (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
        
        GNA13 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14344 GNA13

Gene Names

GNA13

Chain

chain:1-377

Reference Genes

BioGPS Gene:10672 GNA13

COSMIC (genes):GNA13 GNA13

CTD Gene:10672 GNA13

dbSNP Gene:10672 GNA13

ENSEMBL:ENSG00000120063 GNA13

ENSEMBL_homo_sapiens_GENE:ENSG00000120063.10 GNA13

HGNC:4381 GNA13

KEGG Gene (Homo sapiens):10672 GNA13

Monarch:10672 GNA13

NCBI Gene:10672 GNA13

OMIM:604406 GNA13

UCSC:Q14344 GNA13

Reference Transcript

Other Identifiers

10672

1139_at

11717681_at

11717682_a_at

11748689_a_at

11755222_a_at

16847921

206917_PM_at

206917_at

224761_PM_at

224761_at

227539_PM_at

227539_at

2674353

33635_at

3767340

3767341

3767342

3767343

3767344

3767345

3767347

3767355

3767358

3767359

3767360

3767361

47128_at

48764_at

58827_at

7893289

8017711

A_23_P78281

A_24_P150874

A_24_P941441

GE56024

GE80003

GO:0000166

GO:0001525

GO:0001569

GO:0001664

GO:0001701

GO:0003013

GO:0003824

GO:0003924

GO:0005085

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005834

GO:0005886

GO:0005925

GO:0007165

GO:0007186

GO:0007188

GO:0007189

GO:0007204

GO:0007266

GO:0008217

GO:0008360

GO:0010762

GO:0016020

GO:0016787

GO:0019001

GO:0023052

GO:0030154

GO:0030168

GO:0031410

GO:0031526

GO:0031683

GO:0031752

GO:0035556

GO:0042060

GO:0042470

GO:0043226

GO:0046872

GO:0048856

GO:0048870

GO:0051056

GO:0070062

GO:0098772

GO:1904706

GO:1904753

HMNXSV003031280

Hs.87518.0.A1_3p_at

Hs.9691.0.S1_3p_at

ILMN_1758906

ILMN_2176037

L22075_at

PH_hs_0001001

TC17001808.hg

g5729847_3p_at

Participates

as a candidate of

CDC42 GEFs [cytosol] (Homo sapiens)

as a member of

RAC1 GEFs [cytosol] (Homo sapiens)

as a component of

Inferred To

zgc:112436 [plasma membrane] (Danio rerio)

GNA13 [plasma membrane] (Bos taurus)

GNA13 [plasma membrane] (Caenorhabditis elegans)

GNA13 [plasma membrane] (Canis familiaris)

GNA13 [plasma membrane] (Dictyostelium discoideum)

GNA13 [plasma membrane] (Drosophila melanogaster)

GNA13 [plasma membrane] (Gallus gallus)

GNA13 [plasma membrane] (Rattus norvegicus)

GNA13 [plasma membrane] (Saccharomyces cerevisiae)

GNA13 [plasma membrane] (Schizosaccharomyces pombe)

GNA13 [plasma membrane] (Sus scrofa)

G-protein alpha 13 [plasma membrane] (Mus musculus)

gna13 [plasma membrane] (Xenopus tropicalis)

Homologues of GNA13 [plasma membrane] (Dictyostelium discoideum)

gbqA [plasma membrane] (Dictyostelium discoideum)

Cross References

RefSeq

NP_006563.2, NP_001269354.1

OpenTargets

ENSG00000120063

HPA

ENSG00000120063-GNA13

GeneCards

Q14344

Ensembl

ENSG00000120063, ENST00000541118, ENSP00000400717, ENST00000439174, ENSP00000439647

PRO

Q14344

Pharos - Targets

Q14344

Orphanet

26400

HMDB Protein

HMDBP11478

PDB

8H8J, 7SF8, 7T6B, 7SF7

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92888 ARHGEF1	1	ARHGEF1 [cytosol] (R-HSA-114526)	0.564	3

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