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EIF2S2 [cytosol]
Stable Identifier
R-HSA-72512
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF2-beta, eIF-2-beta, eukaryotic translation initiation factor 2 beta subunit, eukaryotic translation initiation factor 2, subunit 2, Eukaryotic translation initiation factor 2 subunit 2, Eukaryotic translation initiation factor 2 beta subunit
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to mitochondrial stress (Homo sapiens)
DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
Translation of ATF4 (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
Translation of DDIT3 (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
Response of EIF2AK1 (HRI) to heme deficiency (Homo sapiens)
Translation of ATF4 (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
Translation of ATF5 (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
Translation of DDIT3 (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
Translation of PPP1R15A (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
PERK regulates gene expression (Homo sapiens)
EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
Translation of ATF4 (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
PKR-mediated signaling (Homo sapiens)
p-PKR dimer phosphorylates eIF2-alpha (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
Formation of the ternary complex, and subsequently, the 43S complex (Homo sapiens)
De novo formation of eIF2:GTP (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
Formation of the 43S pre-initiation complex (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
Met-tRNAi binds to eIF2:GTP to form the ternary complex (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
eIF2:GDP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
Recycling of eIF2:GDP (Homo sapiens)
Formation of eIF2:GDP:eIF2B intermediate (Homo sapiens)
eIF2:GDP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
eIF2:GDP: eIF2B [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
eIF2 activation (Homo sapiens)
eIF2:GDP: eIF2B [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
ABCF1 binds EIF2 (Homo sapiens)
ABCF1:EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20042 EIF2S2
Gene Names
EIF2S2, EIF2B
Chain
initiator methionine:, chain:2-333
Reference Genes
BioGPS Gene:8894 EIF2S2
COSMIC (genes):EIF2S2 EIF2S2
CTD Gene:8894 EIF2S2
dbSNP Gene:8894 EIF2S2
ENSEMBL:ENSG00000125977 EIF2S2
HGNC:3266 EIF2S2
KEGG:hsa:8894 EIF2S2
Monarch:8894 EIF2S2
NCBI Gene:8894 EIF2S2
OMIM:603908 EIF2S2
UCSC:P20042 EIF2S2
Reference Transcript
RefSeq:NM_003908.4 EIF2S2
Other Identifiers
11723916_at
11723917_s_at
16918485
208725_PM_at
208725_at
208726_PM_s_at
208726_s_at
2514932
2514933
2514934
2514937
2708752
3300441
3903289
3903290
3903291
3903292
3903294
3903298
3903300
3903302
3903303
3903310
3903314
3903315
3903321
39368_at
8065730
8894
A_24_P48791
A_32_P157965
GE57907
GE61655
GO:0001701
GO:0001731
GO:0001732
GO:0002176
GO:0002183
GO:0003723
GO:0003729
GO:0003743
GO:0005515
GO:0005737
GO:0005829
GO:0005850
GO:0006412
GO:0006413
GO:0008135
GO:0008584
GO:0022414
GO:0031369
GO:0045182
GO:0045202
GO:0046872
GO:0048856
GO:0065003
HMNXSV003024987
Hs.12163.0.A2_3p_at
ILMN_1798014
M29536_at
PH_hs_0030152
TC20000779.hg
g12653382_3p_a_at
Participates
as a component of
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Inferred To
EIF2B [cytosol]
(Gallus gallus)
Eif2s2 [cytosol]
(Mus musculus)
Eif2s2 [cytosol]
(Rattus norvegicus)
EIF2S2 [cytosol]
(Bos taurus)
EIF2S2 [cytosol]
(Canis familiaris)
EIF2S2 [cytosol]
(Plasmodium falciparum)
EIF2S2 [cytosol]
(Sus scrofa)
eif-2beta [cytosol]
(Caenorhabditis elegans)
SUI3 [cytosol]
(Saccharomyces cerevisiae)
eif2s2 [cytosol]
(Danio rerio)
eif2s2 [cytosol]
(Dictyostelium discoideum)
eif2s2 [cytosol]
(Xenopus tropicalis)
eIF2beta [cytosol]
(Drosophila melanogaster)
tif212 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_003899.2
ENSEMBL
ENSP00000364119
,
ENST00000374980
OpenTargets
ENSG00000125977
HPA
ENSG00000125977-EIF2S2
PRO
P20042
Pharos - Targets
P20042
GlyGen
P20042
HMDB Protein
HMDBP08449
PDB
8PPL
,
7D43
,
6ZP4
,
6YBV
,
7A09
,
6ZMW
,
7QP6
,
6K71
,
8OZ0
,
6K72
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.666
4
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
6
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
12
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.556
3
UniProt:Q92673 SORL1
2
SORL1 [endosome membrane]
(R-HSA-8871475)
SORL1 [Golgi membrane]
(R-HSA-8871510)
0.556
3
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.556
3
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.556
3
UniProt:P01138 NGF
7
NGF [Golgi lumen]
(R-HSA-166515)
NGF(19-241) [extracellular region]
(R-HSA-187033)
NGF [cytosol]
(R-HSA-190059)
NGF(1-241) [endoplasmic reticulum lumen]
(R-HSA-187026)
NGF(19-241) [Golgi lumen]
(R-HSA-187036)
NGF(19-241) [endoplasmic reticulum lumen]
(R-HSA-187047)
NGF [extracellular region]
(R-HSA-167034)
0.556
3
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
6
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