Reactome | TAB1(1-444) [cytosol]

TAB1(1-444) [cytosol]

Stable Identifier

R-HSA-9729751

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Mitogen-activated protein kinase kinase kinase 7 interacting protein 1

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        SARS-CoV-2 3CLpro dimer cleaves TAB1 (Homo sapiens)
        
        TAB1(1-444) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15750 TAB1

Gene Names

TAB1, MAP3K7IP1

Chain

chain:1-504

Reference Genes

BioGPS Gene:10454 TAB1

COSMIC (genes):TAB1 TAB1

CTD Gene:10454 TAB1

dbSNP Gene:10454 TAB1

ENSEMBL:ENSG00000100324 TAB1

ENSEMBL_homo_sapiens_GENE:ENSG00000100324.14 TAB1

HGNC:18157 TAB1

KEGG Gene (Homo sapiens):10454 TAB1

Monarch:10454 TAB1

NCBI Gene:10454 TAB1

OMIM:602615 TAB1

UCSC:Q15750 TAB1

Reference Transcript

Other Identifiers

10454

11719090_at

11719091_a_at

11731875_at

11748478_a_at

16930238

16930256

16930262

203901_at

233679_3p_at

233679_PM_at

233679_at

235827_PM_at

235827_at

35634_at

3945819

3945820

3945824

3945825

3945826

3945828

3945830

3945831

3945832

3945833

3945834

3945835

3945838

3945839

3945840

3945841

3945842

3945843

3945844

3945845

3945846

3945850

3945851

3945852

3945853

48299_at

8073114

A_14_P113192

GE60441

GO:0001701

GO:0003007

GO:0003279

GO:0003824

GO:0004722

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005783

GO:0005829

GO:0006470

GO:0007179

GO:0008047

GO:0010008

GO:0016301

GO:0016310

GO:0016607

GO:0016740

GO:0016787

GO:0019209

GO:0023052

GO:0030324

GO:0031410

GO:0032991

GO:0035904

GO:0036211

GO:0038061

GO:0043226

GO:0043410

GO:0043539

GO:0044877

GO:0048273

GO:0048856

GO:0060090

GO:0060976

GO:0071902

GO:0098772

GO:0140096

HMNXSV003018038

HMNXSV003023970

Hs.31767.0.S1_3p_at

Hs.31767.0.S1_3p_x_at

Hs.87701.0.A1_3p_at

ILMN_1709114

ILMN_1772817

ILMN_1777980

PH_hs_0024621

TC22001112.hg

TC22001113.hg

TC22001470.hg

U49928_at

g5174702_3p_at

Participates

as an output of

SARS-CoV-2 3CLpro dimer cleaves TAB1 (Homo sapiens)

Other forms of this molecule

TAB1(445-504) [cytosol]

TAB1(133-504) [cytosol]

TAB1(1-132) [cytosol]

TAB1 [endosome membrane]

TAB1 [cytosol]

Cross References

RefSeq

NP_006107.1, NP_705717.1

OpenTargets

ENSG00000100324

GeneCards

Q15750

HPA

ENSG00000100324-TAB1

ZINC - Substances

TAB1_HUMAN

ZINC target

Q15750

ZINC - Biogenic

TAB1_HUMAN

Ensembl

ENST00000216160, ENST00000331454, ENSG00000100324, ENSP00000333049, ENSP00000216160

PRO

Q15750

Pharos - Targets

Q15750

ZINC - Predictions - Purchasable

TAB1_HUMAN

PDB

5E7R, 8XI8, 5GJD, 4L53, 2POM, 5O90, 5JH6, 5J8I, 5VVU, 4O91, 7NTI, 4L3P, 5GJF, 4GS6, 2YDS, 2POP, 5NZZ, 5J7S, 5JK3, 5JGB, 8GW3, 5JGA, 5GJG, 4KA3, 2YIY, 4AY6, 2J4O, 5DIY, 5V5N, 7NTH, 4L52, 5JGD, 4AY5, 5J9L

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NYJ8 TAB2	4	TAB2 [cytosol] (R-HSA-168117) TAB2 [endosome membrane] (R-HSA-450279) TAB2 [plasma membrane] (R-HSA-168116) TAB2 [nucleoplasm] (R-HSA-1253323)	0.902	9
UniProt:O43318 MAP3K7	10	PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) MAP3K7 [plasma membrane] (R-HSA-9012677) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) p-MAP3K7 [cytosol] (R-HSA-168163) p-T187-MAP3K7 [cytosol] (R-HSA-206014) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.899	10
UniProt:P98170 XIAP	3	XIAP [nucleoplasm] (R-HSA-3322366) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [cytosol] (R-HSA-50849)	0.748	5
UniProt:Q16539 MAPK14	7	MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.713	4
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.669	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.653	3
UniProt:Q8N5C8 TAB3	3	TAB3 [plasma membrane] (R-HSA-446879) TAB3 [endosome membrane] (R-HSA-450247) TAB3 [cytosol] (R-HSA-450264)	0.643	5
UniProt:O43318-2 MAP3K7			0.564	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.564	2
UniProt:P47929 LGALS7	1	LGALS7 [cytosol] (R-HSA-9861116)	0.556	3
UniProt:P34931 HSPA1L	2	HSPA1L [cytosol] (R-HSA-3371410) HSPA1L [nucleoplasm] (R-HSA-5082367)	0.536	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.528	4
UniProt:Q9Y6C2 EMILIN1	1	EMILIN1 [extracellular region] (R-HSA-2161355)	0.527	3
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.527	2
UniProt:Q12765 SCRN1			0.527	2
UniProt:P05120 SERPINB2	2	SERPINB2 [plasma membrane] (R-HSA-159004) SERPINB2 [extracellular region] (R-HSA-158997)	0.527	2
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.527	2
UniProt:Q8N4J0 CARNMT1	1	CARNMT1 [cytosol] (R-HSA-8876689)	0.527	3
UniProt:Q6ZMQ8 LMTK1			0.519	2
UniProt:Q01974 ROR2	2	ROR2 [plasma membrane] (R-HSA-197731) ROR2 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140729)	0.519	2
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.488	2
UniProt:Q8N448 LNX2			0.488	2
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.483	3
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.471	2

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