Reactome | SMAD1 [cytosol]

SMAD1 [cytosol]

Stable Identifier

R-HSA-201468

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

R-Smad1, Mothers against decapentaplegic homolog 1, SMA1_HUMAN

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)
        
        USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Homo sapiens)
        
        SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Homo sapiens)
        
        SMAD1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15797 SMAD1

Gene Names

SMAD1, BSP1, MADH1, MADR1

Chain

chain:1-465

Reference Genes

BioGPS Gene:4086 SMAD1

COSMIC (genes):SMAD1 SMAD1

CTD Gene:4086 SMAD1

dbSNP Gene:4086 SMAD1

ENSEMBL:ENSG00000170365 SMAD1

HGNC:6767 SMAD1

KEGG:hsa:4086 SMAD1

Monarch:4086 SMAD1

NCBI Gene:4086 SMAD1

OMIM:601595 SMAD1

UCSC:Q15797 SMAD1

Reference Transcript

Other Identifiers

11723044_at

11747501_a_at

1325_at

208015_PM_at

208015_at

210993_PM_s_at

210993_s_at

227798_PM_at

227798_at

2746118

2746120

2746121

2746122

2746123

2746124

2746125

2746126

2746127

2746130

2746131

2746132

2746135

2746138

2746139

2746140

2746141

2746142

2746143

2746144

2746147

2746148

2746150

2746151

37280_at

4086

50875_at

8097657

A_14_P103768

A_14_P105440

A_23_P212870

A_23_P334271

A_24_P71938

GE59266

GE84973

GO:0000165

GO:0000785

GO:0000978

GO:0000981

GO:0001228

GO:0001503

GO:0001649

GO:0001657

GO:0001710

GO:0002051

GO:0003161

GO:0003677

GO:0003700

GO:0003723

GO:0005515

GO:0005634

GO:0005637

GO:0005654

GO:0005667

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006954

GO:0007165

GO:0007179

GO:0007276

GO:0008283

GO:0008285

GO:0009653

GO:0009880

GO:0010468

GO:0010628

GO:0016020

GO:0017151

GO:0019901

GO:0022414

GO:0030154

GO:0030509

GO:0030901

GO:0030902

GO:0031053

GO:0031625

GO:0032991

GO:0042592

GO:0042802

GO:0043226

GO:0043565

GO:0045669

GO:0045944

GO:0046872

GO:0048856

GO:0051148

GO:0051216

GO:0060038

GO:0060348

GO:0060395

GO:0061036

GO:0070410

GO:0070411

GO:0070878

GO:0071141

GO:0071142

GO:0071144

GO:0071407

GO:0140110

GO:1902895

GO:1903672

HMNXSV003005904

Hs.322710.0.A1_3p_at

ILMN_1670540

ILMN_1705392

PH_hs_0024460

PH_hs_0032859

TC04000711.hg

U59423_at

g1332713_3p_a_at

g7661687_3p_at

p26270

Participates

as a member of

Other forms of this molecule

p-S463,S465-SMAD1 [nucleoplasm]

p-S463,S465-SMAD1 [cytosol]

Ub-SMAD1 [cytosol]

Inferred To

Homologues of SMAD1 [cytosol] (Caenorhabditis elegans)

smad1 [cytosol] (Xenopus tropicalis)

daf-14 [cytosol] (Caenorhabditis elegans)

SMAD1 [cytosol] (Bos taurus)

SMAD1 [cytosol] (Caenorhabditis elegans)

SMAD1 [cytosol] (Canis familiaris)

SMAD1 [cytosol] (Danio rerio)

SMAD1 [cytosol] (Drosophila melanogaster)

SMAD1 [cytosol] (Gallus gallus)

SMAD1 [cytosol] (Mus musculus)

SMAD1 [cytosol] (Rattus norvegicus)

SMAD1 [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_011530266.1, XP_011530264.1, XP_011530263.1, XP_011530265.1, XP_006714280.1, NP_001003688.1, NP_005891.1, XP_005263049.1

OpenTargets

ENSG00000170365

ENSEMBL

ENSP00000305769, ENST00000302085, ENSP00000377652, ENST00000394092, ENST00000515385, ENSP00000426568

HPA

ENSG00000170365-SMAD1

PRO

Q15797

Pharos - Targets

Q15797

PDB

2LB1, 2LB0, 3Q4A, 1KHU, 3Q47, 5ZOK, 2LAZ, 2LAX, 2LAY, 2LAW

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.946	12
UniProt:Q9HAU4 SMURF2	2	SMURF2 [nucleoplasm] (R-HSA-178202) SMURF2 [cytosol] (R-HSA-173537)	0.855	7
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.666	4
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.612	4
UniProt:P10275 AR	4	AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984)	0.602	6
UniProt:Q9HCE7 SMURF1	2	SMURF1 [cytosol] (R-HSA-975972) SMURF1 [nucleoplasm] (R-HSA-3004548)	0.573	2
UniProt:P49841 GSK3B	4	GSK3B [cytosol] (R-HSA-2997551) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [nucleoplasm] (R-HSA-2022823) GSK3B del304-316 [cytosol] (R-HSA-5339682)	0.571	2
UniProt:O43541 SMAD6	1	SMAD6 [cytosol] (R-HSA-3006350)	0.567	4
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.556	3
UniProt:O15397 IPO8	2	IPO8 [cytosol] (R-HSA-5578740) IPO8 [nucleoplasm] (R-HSA-5578747)	0.544	2
UniProt:P46937 YAP1	8	YAP1 [nucleoplasm] (R-HSA-1253322) YAP1 [cytosol] (R-HSA-1253345) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y407-YAP1 [cytosol] (R-HSA-9865208)	0.544	3

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