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ACTL6A [nucleoplasm]
Stable Identifier
R-HSA-2980912
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Actin-like protein 6A, ACL6A_HUMAN
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HATs acetylate histones (Homo sapiens)
NuA4 complex acetylates histone H2A, HIST1H4 (Homo sapiens)
NuA4 [nucleoplasm] (Homo sapiens)
ACTL6A [nucleoplasm] (Homo sapiens)
RMTs methylate histone arginines (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Homo sapiens)
SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
ACTL6A [nucleoplasm] (Homo sapiens)
COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Homo sapiens)
SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
ACTL6A [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
ACTL6A [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
ACTL6A [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
DNA Damage Recognition in GG-NER (Homo sapiens)
XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Homo sapiens)
INO80 complex [nucleoplasm] (Homo sapiens)
ACTL6A [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in pigmentation (Homo sapiens)
MITF-M and the SWI/SNF complex bind the TYR promoter (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
ACTL6A [nucleoplasm] (Homo sapiens)
M-MITF dimer:BAF complex:TYR gene [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
ACTL6A [nucleoplasm] (Homo sapiens)
MITF-M dimer and the SWI/SNF complex bind the TYRP1 promoter (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
ACTL6A [nucleoplasm] (Homo sapiens)
MITF-M dimer:BAF complex:TYRP1 gene [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
ACTL6A [nucleoplasm] (Homo sapiens)
MITF-M-dependent TYR gene expression (Homo sapiens)
M-MITF dimer:BAF complex:TYR gene [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
ACTL6A [nucleoplasm] (Homo sapiens)
MITF-M-dependent TYRP1 gene expression (Homo sapiens)
MITF-M dimer:BAF complex:TYRP1 gene [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
ACTL6A [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Regulation of endogenous retroelements (Homo sapiens)
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) (Homo sapiens)
DNMT3A:DNMT3L in nascent RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L methylates cytosine in DNA (Homo sapiens)
nascent LINE-1 RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
ACTL6A [nucleoplasm] (Homo sapiens)
PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
ACTL6A [nucleoplasm] (Homo sapiens)
nascent LINE-1 RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
ACTL6A [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
RUNX1 binds the SWI/SNF complex (Homo sapiens)
RUNX1:CBFB:SWI/SNF [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
ACTL6A [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
ACTL6A [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
UCH proteinases (Homo sapiens)
UCHL5 binds INO80 complex (Homo sapiens)
INO80 complex [nucleoplasm] (Homo sapiens)
ACTL6A [nucleoplasm] (Homo sapiens)
UCHL5:INO80 complex [nucleoplasm] (Homo sapiens)
INO80 complex [nucleoplasm] (Homo sapiens)
ACTL6A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O96019 ACTL6A
Gene Names
ACTL6A, BAF53, BAF53A, INO80K
Chain
initiator methionine:, chain:2-429
Reference Genes
BioGPS Gene:86 ACTL6A
COSMIC (genes):ACTL6A ACTL6A
CTD Gene:86 ACTL6A
dbSNP Gene:86 ACTL6A
ENSEMBL:ENSG00000136518 ACTL6A
HGNC:24124 ACTL6A
KEGG:hsa:86 ACTL6A
Monarch:86 ACTL6A
NCBI Gene:86 ACTL6A
OMIM:604958 ACTL6A
UCSC:O96019 ACTL6A
Reference Transcript
RefSeq:NM_004301.4 ACTL6A
RefSeq:NM_177989.3 ACTL6A
RefSeq:NM_178042.3 ACTL6A
Other Identifiers
11720784_a_at
16948278
202666_PM_s_at
202666_s_at
2654029
2654030
2654031
2654032
2654033
2654034
2654036
2654037
2654038
2654039
2654040
2654041
2654042
2654043
2654044
2654045
2654046
2654047
2654048
2654049
2654050
2654051
2654052
2654053
2654054
2654056
2654057
2654058
2654059
2654060
3107195
41278_at
8084067
86
A_14_P120471
A_23_P69249
GE79733
GE87452
GO:0000723
GO:0000776
GO:0000785
GO:0000786
GO:0001825
GO:0003407
GO:0003677
GO:0003682
GO:0003713
GO:0005515
GO:0005634
GO:0005654
GO:0005886
GO:0006275
GO:0006281
GO:0006282
GO:0006310
GO:0006325
GO:0006338
GO:0006355
GO:0006357
GO:0007165
GO:0007399
GO:0008284
GO:0016363
GO:0016514
GO:0016586
GO:0021510
GO:0030071
GO:0031011
GO:0031492
GO:0032200
GO:0032991
GO:0033044
GO:0035060
GO:0035267
GO:0042981
GO:0043226
GO:0045582
GO:0045596
GO:0045597
GO:0045663
GO:0045739
GO:0045893
GO:0045995
GO:0048856
GO:0051726
GO:0060090
GO:0060382
GO:0070316
GO:0071564
GO:0140110
GO:0140288
GO:1902459
GO:1904507
GO:1905168
GO:2000045
GO:2000779
GO:2000781
GO:2000819
HMNXSV003034934
ILMN_1749297
ILMN_2328280
PH_hs_0025396
TC03000955.hg
TC03002676.hg
g4757717_3p_s_at
Participates
as a component of
BAF complex [nucleoplasm] (Homo sapiens)
NuA4 [nucleoplasm] (Homo sapiens)
INO80 complex [nucleoplasm] (Homo sapiens)
as a candidate of
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
Inferred To
arpD [nucleoplasm]
(Dictyostelium discoideum)
ACTL6A [nucleoplasm]
(Bos taurus)
ACTL6A [nucleoplasm]
(Canis familiaris)
ACTL6A [nucleoplasm]
(Gallus gallus)
ACTL6A [nucleoplasm]
(Sus scrofa)
Homologues of ACTL6A [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of ACTL6A [nucleoplasm]
(Schizosaccharomyces pombe)
Actl6a [nucleoplasm]
(Mus musculus)
Actl6a [nucleoplasm]
(Rattus norvegicus)
swsn-6 [nucleoplasm]
(Caenorhabditis elegans)
alp5 [nucleoplasm]
(Schizosaccharomyces pombe)
ARP4 [nucleoplasm]
(Saccharomyces cerevisiae)
arp42 [nucleoplasm]
(Schizosaccharomyces pombe)
ARP7 [nucleoplasm]
(Saccharomyces cerevisiae)
Bap55 [nucleoplasm]
(Drosophila melanogaster)
actl6a [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_004292.1
,
NP_829888.1
,
NP_817126.1
OpenTargets
ENSG00000136518
ENSEMBL
ENSP00000376430
,
ENST00000429709
,
ENST00000392662
,
ENSP00000397552
,
ENST00000450518
,
ENSP00000394014
HPA
ENSG00000136518-ACTL6A
PRO
O96019
Pharos - Targets
O96019
Orphanet
ACTL6A
GlyGen
O96019
PDB
8X19
,
8X15
,
7VDV
,
8X1C
,
6LTJ
,
7Y8R
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y230 RUVBL2
1
RUVBL2 [nucleoplasm]
(R-HSA-418321)
0.857
11
UniProt:Q9Y265 RUVBL1
1
RUVBL1 [nucleoplasm]
(R-HSA-418323)
0.848
12
UniProt:P25490 YY1
1
YY1 [nucleoplasm]
(R-HSA-4086091)
0.829
8
UniProt:P51532 SMARCA4
1
SMARCA4 [nucleoplasm]
(R-HSA-201686)
0.669
6
UniProt:Q9Y4A5 TRRAP
1
TRRAP [nucleoplasm]
(R-HSA-3322951)
0.669
6
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.615
3
UniProt:Q96L91 EP400
1
EP400 [nucleoplasm]
(R-HSA-3321987)
0.564
3
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.527
3
UniProt:Q9H2F5 EPC1
1
EPC1 [nucleoplasm]
(R-HSA-3321978)
0.527
4
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.527
2
UniProt:P39748 FEN1
1
FEN1 [nucleoplasm]
(R-HSA-54745)
0.527
2
UniProt:O95619 YEATS4
1
YEATS4 [nucleoplasm]
(R-HSA-3322940)
0.527
5
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