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SMARCE1 [nucleoplasm]
Stable Identifier
R-HSA-389258
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
BAF57
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
RMTs methylate histone arginines (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Homo sapiens)
SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
SMARCE1 [nucleoplasm] (Homo sapiens)
COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Homo sapiens)
SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
SMARCE1 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
SMARCE1 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
SMARCE1 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in pigmentation (Homo sapiens)
MITF-M and the SWI/SNF complex bind the TYR promoter (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCE1 [nucleoplasm] (Homo sapiens)
M-MITF dimer:BAF complex:TYR gene [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCE1 [nucleoplasm] (Homo sapiens)
MITF-M dimer and the SWI/SNF complex bind the TYRP1 promoter (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCE1 [nucleoplasm] (Homo sapiens)
MITF-M dimer:BAF complex:TYRP1 gene [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCE1 [nucleoplasm] (Homo sapiens)
MITF-M-dependent TYR gene expression (Homo sapiens)
M-MITF dimer:BAF complex:TYR gene [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCE1 [nucleoplasm] (Homo sapiens)
MITF-M-dependent TYRP1 gene expression (Homo sapiens)
MITF-M dimer:BAF complex:TYRP1 gene [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCE1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Regulation of endogenous retroelements (Homo sapiens)
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) (Homo sapiens)
DNMT3A:DNMT3L in nascent RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L methylates cytosine in DNA (Homo sapiens)
nascent LINE-1 RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCE1 [nucleoplasm] (Homo sapiens)
PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCE1 [nucleoplasm] (Homo sapiens)
nascent LINE-1 RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCE1 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
RUNX1 binds the SWI/SNF complex (Homo sapiens)
RUNX1:CBFB:SWI/SNF [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
SMARCE1 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
SMARCE1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q969G3 SMARCE1
Gene Names
SMARCE1, BAF57
Chain
chain:1-411
Reference Genes
COSMIC (genes):SMARCE1 SMARCE1
dbSNP Gene:6605 SMARCE1
ENSEMBL:ENSG00000073584 SMARCE1
Participates
as a component of
BAF complex [nucleoplasm] (Homo sapiens)
as a candidate of
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
Inferred To
smarce1 [nucleoplasm]
(Xenopus tropicalis)
swsn-3 [nucleoplasm]
(Caenorhabditis elegans)
SMARCE1 [nucleoplasm]
(Bos taurus)
SMARCE1 [nucleoplasm]
(Canis familiaris)
SMARCE1 [nucleoplasm]
(Dictyostelium discoideum)
SMARCE1 [nucleoplasm]
(Gallus gallus)
SMARCE1 [nucleoplasm]
(Sus scrofa)
Bap111 [nucleoplasm]
(Drosophila melanogaster)
Smarce1 [nucleoplasm]
(Mus musculus)
Smarce1 [nucleoplasm]
(Rattus norvegicus)
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51532 SMARCA4
1
SMARCA4 [nucleoplasm]
(R-HSA-201686)
0.788
8
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.781
7
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.718
6
UniProt:Q9NPI1 BRD7
1
BRD7 [nucleoplasm]
(R-HSA-3222092)
0.643
4
UniProt:Q9NPJ6 MED4
1
MED4 [nucleoplasm]
(R-HSA-350263)
0.556
3
UniProt:P62333 PSMC6
2
PSMC6 [cytosol]
(R-HSA-68783)
PSMC6 [nucleoplasm]
(R-HSA-174319)
0.556
3
UniProt:Q7Z3S9 NOTCH2NLA
3
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
NOTCH2NLA(1-?) [extracellular region]
(R-HSA-9911493)
NOTCH2NLA(?-236) [extracellular region]
(R-HSA-9911490)
0.556
3
UniProt:P40222 TXLNA
1
TXLNA [cytosol]
(R-HSA-449124)
0.556
3
UniProt:Q13099 IFT88
8
PolyUb-Misfolded IFT88 [lysosomal lumen]
(R-HSA-9660026)
PolyUb-Misfolded IFT88 [cytosol]
(R-HSA-9641125)
Ub-Misfolded IFT88 [cytosol]
(R-HSA-9641114)
Misfolded IFT88 [cytosol]
(R-HSA-9640115)
Misfolded IFT88 [cilium]
(R-HSA-9640106)
IFT88 [cilium]
(R-HSA-5610385)
PolyUb-Misfolded IFT88 [late endosome lumen]
(R-HSA-9660031)
IFT88 [ciliary tip]
(R-HSA-5625371)
0.556
3
UniProt:Q9UPT5 EXOC7
2
EXOC7 [cytosol]
(R-HSA-5623386)
EXOC7 [plasma membrane]
(R-HSA-2872288)
0.556
5
UniProt:Q9BXU0 TEX12
1
TEX12 [nucleoplasm]
(R-HSA-912441)
0.556
3
UniProt:Q8N0S2 SYCE1
1
SYCE1 [nucleoplasm]
(R-HSA-912456)
0.556
3
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.527
2
UniProt:Q92769 HDAC2
2
HDAC2 [nucleoplasm]
(R-HSA-205135)
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
0.527
2
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.483
2
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.462
2
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