Reactome | PRDX6 [cytosol]

PRDX6 [cytosol]

Stable Identifier

R-HSA-3343670

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Peroxiredoxin-6, PRDX6_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P30041 PRDX6

Gene Names

PRDX6, AOP2, KIAA0106

Chain

initiator methionine:, chain:2-224

Reference Genes

BioGPS Gene:9588 PRDX6

COSMIC (genes):PRDX6 PRDX6

CTD Gene:9588 PRDX6

dbSNP Gene:9588 PRDX6

ENSEMBL:ENSG00000117592 PRDX6

HGNC:16753 PRDX6

KEGG:hsa:9588 PRDX6

Monarch:9588 PRDX6

NCBI Gene:9588 PRDX6

OMIM:602316 PRDX6

UCSC:P30041 PRDX6

Reference Transcript

RefSeq:NM_004905.2 PRDX6

Other Identifiers

11742998_at

11742999_x_at

11751799_a_at

11757806_x_at

16673945

200844_PM_s_at

200844_s_at

200845_PM_s_at

200845_s_at

2367744

2367745

2367746

2367749

2367750

2367751

2367754

2367755

2367757

2367758

2367759

2755552

39354_at

7907439

9588

A_14_P114905

A_23_P983

D14662_at

GE62305

GO:0003824

GO:0004601

GO:0004602

GO:0004623

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005739

GO:0005764

GO:0005773

GO:0005829

GO:0006629

GO:0006979

GO:0016020

GO:0016042

GO:0016209

GO:0016491

GO:0016740

GO:0016787

GO:0031625

GO:0035578

GO:0042802

GO:0043226

GO:0045296

GO:0045454

GO:0046475

GO:0047184

GO:0047499

GO:0048026

GO:0048471

GO:0051920

GO:0070062

GO:0098754

GO:0098869

HMNXSV003056975

Hs.120.0.A1_3p_a_at

ILMN_1803180

PH_hs_0000020

TC01001510.hg

g4758637_3p_a_at

Participates

as a component of

PRDX6:GSTP1 [cytosol] (Homo sapiens)

Other forms of this molecule

PRDX6 [extracellular region]

PRDX6 [azurophil granule lumen]

Inferred To

prdx-6 [cytosol] (Caenorhabditis elegans)

prdx6 [cytosol] (Danio rerio)

prdx6 [cytosol] (Xenopus tropicalis)

Prdx6 [cytosol] (Mus musculus)

Prdx6 [cytosol] (Rattus norvegicus)

PRDX6 [cytosol] (Bos taurus)

PRDX6 [cytosol] (Canis familiaris)

PRDX6 [cytosol] (Dictyostelium discoideum)

PRDX6 [cytosol] (Plasmodium falciparum)

PRDX6 [cytosol] (Sus scrofa)

Cross References

ENSEMBL

ENSP00000342026, ENST00000340385

OpenTargets

ENSG00000117592

IntEnz

3.1.1.4, 2.3.1.23, 1.11.1.27

HPA

ENSG00000117592-PRDX6

PRO

P30041

Pharos - Targets

P30041

GlyGen

P30041

HMDB Protein

HMDBP00281

PDB

5B6M, 5B6N, 1PRX

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.706	17
UniProt:P12004 PCNA	5	PCNA [nucleoplasm] (R-HSA-68439) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861)	0.573	2
UniProt:P48556 PSMD8	2	PSMD8 [cytosol] (R-HSA-68808) PSMD8 [nucleoplasm] (R-HSA-174318)	0.556	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:P21796 VDAC1	7	p-S65-Ub:VDAC1 [mitochondrial outer membrane] (R-HSA-9834991) K63polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-9834037) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) Ub-VDAC1 [mitochondrial outer membrane] (R-HSA-9834989) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079)	0.499	3
UniProt:Q7KZN9 COX15	1	COX15 [mitochondrial inner membrane] (R-HSA-2995350)	0.499	3

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