Reactome | GPS2 [nucleoplasm]

GPS2 [nucleoplasm]

Stable Identifier

R-HSA-351642

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

GPS2_HUMAN, G protein pathway suppressor 2, AMF1

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by MECP2 (Homo sapiens)
      - Regulation of MECP2 expression and activity (Homo sapiens)
        
        MECP2 binds the NCoR/SMRT complex (Homo sapiens)
        
        MECP2:NCoR/SMRT complex [nucleoplasm] (Homo sapiens)
        
        NCoR/SMRT complex [nucleoplasm] (Homo sapiens)
        
        NCOR1 complex [nucleoplasm] (Homo sapiens)
        
        NCOR1:GPS2 [nucleoplasm] (Homo sapiens)
        
        GPS2 [nucleoplasm] (Homo sapiens)
        
        NCOR2 complex [nucleoplasm] (Homo sapiens)
        
        NCOR2:GPS2 [nucleoplasm] (Homo sapiens)
        
        GPS2 [nucleoplasm] (Homo sapiens)
        
        NCoR/SMRT complex [nucleoplasm] (Homo sapiens)
        
        NCOR1 complex [nucleoplasm] (Homo sapiens)
        
        NCOR1:GPS2 [nucleoplasm] (Homo sapiens)
        
        GPS2 [nucleoplasm] (Homo sapiens)
        
        NCOR2 complex [nucleoplasm] (Homo sapiens)
        
        NCOR2:GPS2 [nucleoplasm] (Homo sapiens)
        
        GPS2 [nucleoplasm] (Homo sapiens)

Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Regulation of lipid metabolism by PPARalpha (Homo sapiens)
    - PPARA activates gene expression (Homo sapiens)
      - Expression of ABCA1 (Homo sapiens)
        
        ABCA1gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Homo sapiens)
        
        NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Homo sapiens)
        
        GPS2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13227 GPS2

Gene Names

GPS2

Chain

chain:1-327

Reference Genes

BioGPS Gene:2874 GPS2

COSMIC (genes):GPS2 GPS2

CTD Gene:2874 GPS2

dbSNP Gene:2874 GPS2

ENSEMBL:ENSG00000132522 GPS2

ENSEMBL:ENSG00000132522.16 GPS2

ENSEMBL:ENSG00000288325.1 GPS2

HGNC:4550 GPS2

KEGG Gene (Homo sapiens):2874 GPS2

Monarch:2874 GPS2

NCBI Gene:2874 GPS2

OMIM:601935 GPS2

UCSC:Q13227 GPS2

Reference Transcript

RefSeq:NM_004489.4 GPS2

Other Identifiers

11747851_a_at

16840620

209350_3p_s_at

209350_PM_s_at

209350_s_at

2874

3196764

3196765

3196771

35653_at

3743612

3743613

3743615

3743616

3743617

3743619

3743621

3743623

3743625

3743627

3743628

3743630

3743632

3743633

3743634

3743635

3743636

3743637

3743638

3743639

8012150

A_33_P3608172

GE85823

GO:0000122

GO:0002376

GO:0003712

GO:0003713

GO:0003714

GO:0005095

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0005739

GO:0005829

GO:0006351

GO:0006354

GO:0006355

GO:0006357

GO:0006629

GO:0006954

GO:0007254

GO:0010804

GO:0010875

GO:0017053

GO:0019216

GO:0023052

GO:0030154

GO:0030183

GO:0030332

GO:0032991

GO:0034122

GO:0035360

GO:0036211

GO:0043086

GO:0043226

GO:0045598

GO:0045599

GO:0045944

GO:0046329

GO:0048856

GO:0050728

GO:0050859

GO:0098772

GO:0098780

GO:1900045

HMNXSV003008563

ILMN_1815158

U28963_at

g7018539_3p_s_at

Participates

as a component of

as an input of

Oxysterol-induced binding of NR1H2,3:RXR to the ABCG1 gene (Homo sapiens)

Inferred To

Gps2 [nucleoplasm] (Mus musculus)

Gps2 [nucleoplasm] (Rattus norvegicus)

Dmel\CG17002 [nucleoplasm] (Drosophila melanogaster)

GPS2 [nucleoplasm] (Bos taurus)

GPS2 [nucleoplasm] (Canis familiaris)

GPS2 [nucleoplasm] (Danio rerio)

GPS2 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_004480.1

OpenTargets

ENSG00000132522

GeneCards

Q13227

HPA

ENSG00000132522-GPS2

Ensembl

ENSG00000132522, ENST00000380728, ENSG00000288325, ENSP00000500255, ENSP00000379841, ENST00000672046, ENST00000389167, ENSP00000370104, ENST00000673265, ENSP00000500677

PRO

Q13227

Pharos - Targets

Q13227

PDB

2L5G

Interactors (52)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.832	11
UniProt:P18848 ATF4	1	ATF4 [nucleoplasm] (R-HSA-381016)	0.83	13
UniProt:Q86VW0 SESD1			0.781	7
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.773	6
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.735	7
UniProt:P06463 VE6			0.729	6
UniProt:P06462 VE6			0.729	6
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.718	6
UniProt:O60907-2 TBL1X			0.656	6
UniProt:A0A024RBS3 A0A024RBS3			0.639	4
UniProt:P03122 VE2			0.593	5
UniProt:Q3LI66 KRTAP6-2	1	KRTAP6-2 [cytosol] (R-HSA-6810261)	0.556	5
UniProt:Q3LI64 KRTAP6-1	1	KRTAP6-1 [cytosol] (R-HSA-6810298)	0.556	3
UniProt:O76013-2 KRT36			0.556	3
UniProt:Q9BYR6 KRTAP3-3	1	KRTAP3-3 [cytosol] (R-HSA-6809859)	0.556	3
UniProt:Q5TA45 INTS11	1	CPSF3L [nucleoplasm] (R-HSA-6807411)	0.556	3
UniProt:Q15038 DAZP2			0.556	3
UniProt:Q05BL1 Q05BL1			0.556	3
UniProt:Q9BYR8 KRTAP3-1	1	KRTAP3-1 [cytosol] (R-HSA-6809868)	0.556	3
UniProt:Q9ULX6 AKP8L			0.556	3
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.556	3
IntAct:EBI-22412087 CCSB ORF ID			0.556	3
UniProt:Q93062 RBPMS			0.556	3
UniProt:Q5TD97 FHL5			0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q52LG2 KRTAP13-2	1	KRTAP13-2 [cytosol] (R-HSA-6810274)	0.556	3
UniProt:Q8IUC1 KRTAP11-1	1	KRTAP11-1 [cytosol] (R-HSA-6810294)	0.556	3
UniProt:Q9UHB4 NDOR1	1	NDOR1 [cytosol] (R-HSA-2564776)	0.556	5
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.556	3
UniProt:Q5BKX5-3 C19ORF54			0.556	3
UniProt:Q15654 TRIP6			0.556	3
UniProt:Q8WUN7 UBTD2			0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:A5D8V6 VPS37C	1	VPS37C [endosome membrane] (R-HSA-184438)	0.556	3
UniProt:A1KXE4-2 FAM168B			0.556	3
IntAct:EBI-22311199 CCSB ORF ID			0.556	3
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.556	5
UniProt:Q53HV7-2 SMUG1			0.556	3
UniProt:Q16633 OBF1			0.556	3
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126):p-8Y FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126):FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:Q9Y2D1 ATF5	1	ATF5 [nucleoplasm] (R-HSA-9653719)	0.556	3
UniProt:P03126 VE6			0.527	3
UniProt:P85037 FOXK1	1	FOXK1 [nucleoplasm] (R-HSA-5689673)	0.527	2
UniProt:P06929 VE6			0.527	2
UniProt:P06428 VE6			0.527	2
UniProt:Q9BZK7 TBL1XR1	1	TBL1XR1 [nucleoplasm] (R-HSA-351643)	0.527	2
UniProt:Q9WMX2-PRO_0000037551			0.508	2
UniProt:P57077 M3KCL			0.508	2
UniProt:P12504 VIF			0.499	2
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.499	2
UniProt:P06921 VE2			0.488	2