Reactome | monoSUMO1-K-DNMT1 [nucleoplasm]

monoSUMO1-K-DNMT1 [nucleoplasm]

Stable Identifier

R-HSA-4655353

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA, DNMT1_HUMAN

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External Reference Information

External Reference

UniProt:P26358 DNMT1

Gene Names

DNMT1, AIM, CXXC9, DNMT

Chain

chain:1-1616

Reference Genes

BioGPS Gene:1786 DNMT1

COSMIC (genes):DNMT1 DNMT1

CTD Gene:1786 DNMT1

dbSNP Gene:1786 DNMT1

ENSEMBL:ENSG00000130816 DNMT1

ENSEMBL:ENSG00000130816.17 DNMT1

HGNC:2976 DNMT1

KEGG Gene (Homo sapiens):1786 DNMT1

Monarch:1786 DNMT1

NCBI Gene:1786 DNMT1

OMIM:126375 DNMT1

UCSC:P26358 DNMT1

Reference Transcript

Other Identifiers

11736405_a_at

11756434_a_at

16868576

1786

201697_PM_s_at

201697_s_at

37333_at

3850070

3850071

3850073

3850076

3850077

3850078

3850079

3850081

3850083

3850084

3850085

3850088

3850090

3850092

3850093

3850096

3850098

3850101

3850102

3850103

3850105

3850107

3850108

3850109

3850110

3850111

3850112

3850113

3850114

3850115

3850116

3850117

3850118

3850120

3850122

3850125

3850128

3850129

3850133

3850134

3850135

3850137

3850138

3850140

3850141

3850142

3850143

3850151

3850152

3850153

8033912

A_24_P408083

A_33_P3329187

GE59898

GO:0000122

GO:0000792

GO:0001674

GO:0003677

GO:0003682

GO:0003723

GO:0003824

GO:0003886

GO:0005515

GO:0005634

GO:0005654

GO:0005657

GO:0005694

GO:0005721

GO:0006306

GO:0006325

GO:0006346

GO:0006351

GO:0006355

GO:0008168

GO:0008270

GO:0008327

GO:0009008

GO:0010424

GO:0010468

GO:0010628

GO:0010629

GO:0012501

GO:0016740

GO:0030154

GO:0032259

GO:0032776

GO:0042127

GO:0043045

GO:0043073

GO:0043226

GO:0044027

GO:0045892

GO:0046872

GO:0048856

GO:0071230

GO:0090116

GO:0140097

GO:1903926

GO:1904707

GO:1905460

GO:1905931

GO:1990841

HMNXSV003058293

ILMN_1760201

PH_hs_0023014

TC19001159.hg

X63692_at

g4503350_3p_a_at

p33939

Participates

as an output of

SUMOyation of DNMT1 with SUMO1 (Homo sapiens)

Other forms of this molecule

DNMT1 [nucleoplasm]

Inferred To

cb1075 [nucleoplasm] (Danio rerio)

monoSUMO1-K-DNMT1 [nucleoplasm] (Bos taurus)

monoSUMO1-K-DNMT1 [nucleoplasm] (Gallus gallus)

monoSUMO1-K-DNMT1 [nucleoplasm] (Mus musculus)

monoSUMO1-K-DNMT1 [nucleoplasm] (Rattus norvegicus)

dnmt1 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at unknown position

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_001370.1, NP_001305660.1, NP_001305659.1, NP_001124295.1

ZINC - World Drugs

DNMT1_HUMAN

Guide to Pharmacology - Targets

2605

OpenTargets

ENSG00000130816

ZINC - Substances

DNMT1_HUMAN

ZINC target

P26358

ZINC - Biogenic

DNMT1_HUMAN

PRO

P26358

PDB

6L1F, 7XIB, 7SFC, 5YDR, 3SWR, 5WVO, 4Z97, 7SFD, 4YOC, 3PTA, 6X9J, 7XI9, 6X9I, 6K3A, 7SFE, 4WXX, 6X9K, 7SFG, 3EPZ, 4Z96, 7SFF

ZINC - Investigational

DNMT1_HUMAN

ZINC - Metabolites

DNMT1_HUMAN

IntEnz

2.1.1.37

GeneCards

P26358

HPA

ENSG00000130816-DNMT1

Ensembl

ENST00000340748, ENSG00000130816, ENSP00000352516, ENSP00000345739, ENST00000359526

Pharos - Targets

P26358

Orphanet

20282

ZINC - Predictions - Purchasable

DNMT1_HUMAN

HMDB Protein

HMDBP05712

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.752	11
UniProt:Q8WTS6 SETD7	1	SETD7 [nucleoplasm] (R-HSA-1183221)	0.74	9
IntAct:EBI-4399559 UBIQ			0.702	3
UniProt:Q96T88 UHRF1	2	UHRF1 [cytosol] (R-HSA-9818452) UHRF1 [nucleoplasm] (R-HSA-212103)	0.696	12
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.693	8
UniProt:Q96JM7 LMBL3			0.674	11
UniProt:Q93009 USP7	2	USP7 [cytosol] (R-HSA-8853511) USP7 [nucleoplasm] (R-HSA-3215278)	0.669	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.628	8
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.623	3
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.611	6
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.597	7
UniProt:Q9UBC3 DNMT3B	2	SUMO1-K-DNMT3B [nucleoplasm] (R-HSA-4655334) DNMT3B [nucleoplasm] (R-HSA-212316)	0.597	5
UniProt:Q96JK2 DCAF5	1	DCAF5 [nucleoplasm] (R-HSA-8955189)	0.576	5
UniProt:Q9QR71 LANA1			0.544	2
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.537	6
UniProt:P0DTC8 8	2	8 [extracellular region] (R-COV-9755410) 8 [endoplasmic reticulum lumen] (R-COV-9727283)	0.527	2
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.508	2
UniProt:P48552 NRIP1	2	monoSUMO1-K756,K1154-NRIP1 [nucleoplasm] (R-HSA-4086057) NRIP1 [nucleoplasm] (R-HSA-4086031)	0.499	3
UniProt:Q77UV9 Q77UV9			0.499	2
IntAct:EBI-1265559 MYC			0.462	2
IntAct:EBI-5276484 ACTB			0.462	2
UniProt:Q9UBB5 MBD2	1	MBD2 [nucleoplasm] (R-HSA-427367)	0.462	3

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