Reactome | EED [nucleoplasm]

EED [nucleoplasm]

Stable Identifier

R-HSA-212278

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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External Reference Information

External Reference

UniProt:O75530 EED

Gene Names

EED

Chain

initiator methionine:, chain:2-441

Reference Genes

BioGPS Gene:8726 EED

COSMIC (genes):EED EED

CTD Gene:8726 EED

dbSNP Gene:8726 EED

ENSEMBL:ENSG00000074266 EED

HGNC:3188 EED

KEGG:hsa:8726 EED

Monarch:8726 EED

NCBI Gene:8726 EED

OMIM:605984 EED

UCSC:O75530 EED

Reference Transcript

Participates

as an output of

E2F1/2/3 stimulates EED transcription (Homo sapiens)

as an input of

Formation of PRC2-EZH2 complex (Homo sapiens)

as a component of

PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)

Inferred To

EED [nucleoplasm] (Bos taurus)

EED [nucleoplasm] (Canis familiaris)

EED [nucleoplasm] (Gallus gallus)

EED [nucleoplasm] (Sus scrofa)

escl [nucleoplasm] (Drosophila melanogaster)

Eed [nucleoplasm] (Mus musculus)

Eed [nucleoplasm] (Rattus norvegicus)

eed [nucleoplasm] (Danio rerio)

eed [nucleoplasm] (Xenopus tropicalis)

mes-6 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001294936.1, NP_003788.2

Guide to Pharmacology - Targets

2487

ENSEMBL

ENST00000327320, ENSP00000338186, ENST00000263360, ENSG00000074266, ENSP00000263360, ENST00000351625, ENSP00000500834, ENST00000672825, ENSP00000315587

OpenTargets

ENSG00000074266

GeneCards

EED

HPA

ENSG00000074266-EED

ZINC - Substances

EED_HUMAN

ZINC target

O75530

PRO

O75530

Pharos - Targets

O75530

PDB

4X3E, 3JZN, 7KXT, 6V3X, 8FYH, 5H19, 5H17, 5IJ8, 6W7F, 5WG6, 7SI5, 7QK4, 5TTW, 5GSA, 7QJG, 3K26, 7MSB, 3IJC, 3IIY, 7P3J, 3IIW, 7P3C, 3IJ1, 6SFC, 6YVI, 6SFB, 5K0M, 5U8F, 8EQV, 4W2R, 5U62, 7KSO, 5U5K, 6WKR, 7KSR, 5U5H, 6C23, 8TAS, 5H15, 3JZH, 5H13, 3IJ0, 6LO2, 3JZG, 5U6D, 7SI4, 6W7G, 5IJ7, 5U69, 3K27, 5HYN, 5H25, 5LS6, 3JPX, 7MSD, 7QJU, 5H24, 7P3G, 7TD5, 5WP3, 6YVJ, 5WUK, 6B3W, 7KTP, 5U8A, 6U4Y, 5U5T, 8T9G, 9C8U, 8TB9, 6C24, 5H14, 6V3Y

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.922	17
UniProt:Q15022 SUZ12	2	SUZ12 [nucleoplasm] (R-HSA-212217) monoSUMO1-K75-SUZ12 [nucleoplasm] (R-HSA-4615932)	0.909	12
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.788	8
UniProt:Q92800 EZH1			0.738	5
UniProt:O43189 PHF1	1	PHF1 [nucleoplasm] (R-HSA-5084105)	0.725	6
UniProt:Q9UBC3 DNMT3B	2	DNMT3B [nucleoplasm] (R-HSA-212316) SUMO1-K-DNMT3B [nucleoplasm] (R-HSA-4655334)	0.662	4
UniProt:Q6ZN18 AEBP2	1	AEBP2 [nucleoplasm] (R-HSA-5082342)	0.648	5
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.643	6
UniProt:Q92833 JARID2	1	JARID2 [nucleoplasm] (R-HSA-2160949)	0.643	4
UniProt:Q9Y483 MTF2	1	MTF2 [nucleoplasm] (R-HSA-5084119)	0.643	4
UniProt:Q5T6S3 PHF19	1	PHF19 [nucleoplasm] (R-HSA-5084115)	0.643	5
UniProt:P26358 DNMT1	2	DNMT1 [nucleoplasm] (R-HSA-212181) monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353)	0.623	3
IntAct:EBI-15887193 H3K27-1			0.618	3
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.564	4
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.564	2
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.558	7
IntAct:EBI-15697673 H4K20AC			0.558	2
IntAct:EBI-15887169 H1K26			0.558	2
IntAct:EBI-15887143 H3K79			0.558	2
IntAct:EBI-15643864 H3K9-1			0.558	5
UniProt:P63244 RACK1	1	RACK1 [cytosol] (R-HSA-5626956)	0.527	3
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.527	3
UniProt:Q6ZN18-2 AEBP2			0.527	2
UniProt:A6NHQ4 EPOP			0.527	3
UniProt:Q9JJY3	1	SMPD3 [plasma membrane] (R-MMU-1606265)	0.527	5
UniProt:Q96JN0 LCOR			0.527	4
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.525	2
UniProt:Q9Y6K1 DNMT3A	2	DNMT3A [nucleoplasm] (R-HSA-212287) monoSUMO1-K-DNMT3A [nucleoplasm] (R-HSA-4655415)	0.499	2
UniProt:Q92833-1 JARID2			0.499	4
UniProt:Q8IXJ9 ASXL1	1	ASXL1 [nucleoplasm] (R-HSA-5689645)	0.499	5
UniProt:Q15156 Q15156			0.499	2