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SLC25A6 [mitochondrial inner membrane]
Stable Identifier
R-HSA-49745
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
ADP/ATP translocase 3 monomer, ADP,ATP carrier protein, liver isoform T2, adenine nucleotide translocator 3, ADP/ATP translocase 3, Adenine nucleotide translocator 3, ANT 3
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
Interactions of Vpr with host cellular proteins (Homo sapiens)
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization (Homo sapiens)
Association of Vpr with ANT1 (Homo sapiens)
ADP/ATP translocase monomer (generic) [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 [mitochondrial inner membrane] (Homo sapiens)
ANT1:Vpr complex [mitochondrial inner membrane] (Homo sapiens)
ADP/ATP translocase monomer (generic) [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 [mitochondrial inner membrane] (Homo sapiens)
Influenza Infection (Homo sapiens)
Influenza Virus Induced Apoptosis (Homo sapiens)
PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis (Homo sapiens)
PB1-F2: ANT 3 Complex [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 [mitochondrial inner membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Mitochondrial protein degradation (Homo sapiens)
LONP1 binds mitochondrial inner membrane proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial inner membrane) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 [mitochondrial inner membrane] (Homo sapiens)
Substrate of LONP1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 [mitochondrial inner membrane] (Homo sapiens)
LONP1 degrades mitochondrial inner membrane proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial inner membrane) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 [mitochondrial inner membrane] (Homo sapiens)
Protein localization (Homo sapiens)
Mitochondrial protein import (Homo sapiens)
TIMM9:TIMM10 binds hydrophobic proteins (Homo sapiens)
TIMM9:TIMM10:Protein [mitochondrial inner membrane] (Homo sapiens)
Proteins Chaperoned by TIMM9:TIMM10 [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 [mitochondrial inner membrane] (Homo sapiens)
TIMM9:TIMM10 transfers proteins to TIMM22 (Homo sapiens)
TIMM9:TIMM10:Protein [mitochondrial inner membrane] (Homo sapiens)
Proteins Chaperoned by TIMM9:TIMM10 [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 [mitochondrial inner membrane] (Homo sapiens)
TIMM9:TIMM10:TIMM10B:TIM22:Protein [mitochondrial inner membrane] (Homo sapiens)
Proteins Chaperoned by TIMM9:TIMM10 [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 [mitochondrial inner membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of vitamins, nucleosides, and related molecules (Homo sapiens)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Homo sapiens)
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Homo sapiens)
SLC25A5,6 dimers [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 dimer [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 [mitochondrial inner membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
12450408
The human mitochondrial ADP/ATP carriers: kinetic properties and biogenesis of wild-type and mutant proteins in the yeast S. cerevisiae.
Brandolin, G
,
Lauquin, GJ
,
Dianoux, AC
,
De Marcos Lousa, C
,
Trézéguet, V
Biochemistry
2002
External Reference Information
External Reference
UniProt:P12236 SLC25A6
Gene Names
SLC25A6, AAC3, ANT3, CDABP0051
Chain
chain:1-298, initiator methionine:, chain:2-298
Reference Genes
COSMIC (genes):SLC25A6 SLC25A6
ENSEMBL:ENSG00000169100 SLC25A6
HGNC:10992 SLC25A6
UCSC:P12236 SLC25A6
Other Identifiers
11729584_a_at
11729585_x_at
17108705
17116720
212085_PM_at
212085_at
212826_PM_s_at
212826_s_at
293
3997375
3997376
3997377
3997378
3997379
3997380
3997381
3997386
3997387
3997388
3997390
4033176
4033177
4033178
4033179
4033180
4033181
4033182
4033187
4033188
4033189
4033191
40435_at
40436_g_at
8171111
8177003
88085_at
A_23_P33752
A_33_P3411397
A_33_P3589217
GO:0005215
GO:0005471
GO:0005515
GO:0005634
GO:0005739
GO:0005743
GO:0005744
GO:0006915
GO:0007005
GO:0012501
GO:0015297
GO:0016020
GO:0043226
GO:0055085
GO:0061024
GO:0140021
GO:1901029
GO:1990544
HMNXSV003028977
Hs.164280.0.A1_3p_a_at
Hs.164280.1.A1_3p_at
J03592_at
PH_hs_0016939
TC0X000798.hg
TC0Y000115.hg
Participates
as a member of
Substrate of LONP1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
Proteins Chaperoned by TIMM9:TIMM10 [mitochondrial inner membrane] (Homo sapiens)
ADP/ATP translocase monomer (generic) [mitochondrial inner membrane] (Homo sapiens)
as a component of
PB1-F2: ANT 3 Complex [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 dimer [mitochondrial inner membrane] (Homo sapiens)
as an input of
PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis (Homo sapiens)
Other forms of this molecule
SLC25A6 [mitochondrial intermembrane space]
Inferred To
slc25a5 [mitochondrial inner membrane]
(Danio rerio)
slc25a5 [mitochondrial inner membrane]
(Xenopus tropicalis)
Homologues of SLC25A5 [mitochondrial inner membrane]
(Caenorhabditis elegans)
Homologues of SLC25A5 [mitochondrial inner membrane]
(Drosophila melanogaster)
Homologues of SLC25A5 [mitochondrial inner membrane]
(Plasmodium falciparum)
Homologues of SLC25A5 [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
Ant2 [mitochondrial inner membrane]
(Drosophila melanogaster)
SLC25A6 [mitochondrial inner membrane]
(Bos taurus)
SLC25A6 [mitochondrial inner membrane]
(Canis familiaris)
SLC25A6 [mitochondrial inner membrane]
(Gallus gallus)
SLC25A6 [mitochondrial inner membrane]
(Sus scrofa)
SLC25A5 [mitochondrial inner membrane]
(Caenorhabditis elegans)
SLC25A5 [mitochondrial inner membrane]
(Dictyostelium discoideum)
SLC25A5 [mitochondrial inner membrane]
(Drosophila melanogaster)
SLC25A5 [mitochondrial inner membrane]
(Plasmodium falciparum)
SLC25A5 [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
SLC25A5 [mitochondrial inner membrane]
(Schizosaccharomyces pombe)
Cross References
Guide to Pharmacology - Targets
1064
ENSEMBL
ENSP00000370808
,
ENST00000381401
,
ENSP00000518609
,
ENST00000711214
OpenTargets
ENSG00000169100
HPA
ENSG00000169100-SLC25A6
PRO
P12236
Pharos - Targets
P12236
GlyGen
P12236
HMDB Protein
HMDBP03918
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63010 AP2B1
4
AP2B1 [endolysosome membrane]
(R-HSA-6784827)
AP2B1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130489)
AP2B1 [cytosol]
(R-HSA-182166)
AP2B1 [plasma membrane]
(R-HSA-167690)
0.666
4
UniProt:Q5JR59 MTUS2
0.666
4
UniProt:P0C0U1 PB1
2
PB1-F2 [mitochondrial intermembrane space]
(R-FLU-5146789)
PB1-F2 [cytosol]
(R-FLU-169216)
0.591
5
UniProt:P21796 VDAC1
7
p-S65-Ub:VDAC1 [mitochondrial outer membrane]
(R-HSA-9834991)
K63polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-9834037)
K48polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-5205624)
Ub-VDAC1 [mitochondrial outer membrane]
(R-HSA-9834989)
VDAC1 [mitochondrial outer membrane]
(R-HSA-1267988)
VDAC1 [mitochondrial intermembrane space]
(R-HSA-1267960)
PolyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-6783079)
0.564
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.564
2
UniProt:Q8WW24 TEKT4
0.556
3
UniProt:Q7Z3S9 NOTCH2NLA
3
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
NOTCH2NLA(1-?) [extracellular region]
(R-HSA-9911493)
NOTCH2NLA(?-236) [extracellular region]
(R-HSA-9911490)
0.556
3
UniProt:P36406 TRI23
0.556
3
UniProt:Q9UJV3-2 MID2
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:Q15654 TRIP6
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
2
UniProt:Q17R55 F187B
0.527
2
UniProt:P05141 SLC25A5
1
SLC25A5 [mitochondrial inner membrane]
(R-HSA-49743)
0.527
2
UniProt:Q9UBP4 DKK3
0.527
2
UniProt:Q07954 LRP1
2
LRP1 [endocytic vesicle membrane]
(R-HSA-2230981)
LRP1 [plasma membrane]
(R-HSA-1454844)
0.527
2
UniProt:O14498 ISLR
2
ISLR [extracellular region]
(R-HSA-8848919)
ISLR [platelet alpha granule lumen]
(R-HSA-8848912)
0.527
3
UniProt:Q77M19 Q77M19
0.527
3
UniProt:Q9Y279 VSIG4
0.527
2
UniProt:Q9HCL2 GPAM
1
GPAM(1-828) [mitochondrial outer membrane]
(R-HSA-61855)
0.499
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
5
UniProt:A0A0F6B5H5 A0A0F6B5H5
0.462
2
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