Reactome | NME4 [mitochondrial inner membrane]

NME4 [mitochondrial inner membrane]

Stable Identifier

R-HSA-60026

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

non-metastatic cells 4, protein expressed in, Nucleoside diphosphate kinase, mitochondrial, nm23-H4, NDP kinase, mitochondrial

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
10799505	The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase Milon, L, Meyer, P, Chiadmi, M, Munier, A, Johansson, M, Karlsson, A, Lascu, I, Capeau, J, Janin, J, Lacombe, ML	J Biol Chem	2000

External Reference Information

External Reference

UniProt:O00746 NME4

Gene Names

NME4, NM23D

Chain

transit peptide:1-28, chain:29-187

Reference Genes

BioGPS Gene:4833 NME4

COSMIC (genes):NME4 NME4

CTD Gene:4833 NME4

dbSNP Gene:4833 NME4

ENSEMBL:ENSG00000103202 NME4

HGNC:7852 NME4

KEGG:hsa:4833 NME4

Monarch:4833 NME4

NCBI Gene:4833 NME4

OMIM:601818 NME4

UCSC:O00746 NME4

Reference Transcript

Other Identifiers

11754486_a_at

16814211

212739_PM_s_at

212739_s_at

3642818

3642819

3642820

3642821

3642822

3642823

3642824

3642825

3642826

3642827

3642828

3642829

3642830

3642831

3642832

3642834

3642836

3642838

3642840

3642841

3642842

3642844

3642846

3642852

3642856

3642857

3642870

3642872

3642874

39089_at

4833

7991837

A_14_P136199

A_24_P210829

A_33_P3393408

GE60243

GE86871

GO:0000166

GO:0004550

GO:0005515

GO:0005524

GO:0005543

GO:0005739

GO:0005741

GO:0005743

GO:0005758

GO:0005759

GO:0006183

GO:0006228

GO:0006241

GO:0006869

GO:0008289

GO:0009116

GO:0009117

GO:0016020

GO:0016301

GO:0016740

GO:0034214

GO:0044877

GO:0046872

GO:0051020

GO:0055086

GO:0060090

GO:0065003

GO:0120010

GO:0140339

GO:0160204

GO:1901135

GO:1901612

HMNXSV003029418

Hs.9235.1.S1_3p_a_at

ILMN_1800634

PH_hs_0028747

PH_hs_0030972

TC16002049.hg

Y07604_at

Participates

as a component of

NME4 hexamer [mitochondrial inner membrane] (Homo sapiens)

Inferred To

YNK1 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

Homologues of NME4 [mitochondrial inner membrane] (Caenorhabditis elegans)

Homologues of NME4 [mitochondrial inner membrane] (Dictyostelium discoideum)

Homologues of NME4 [mitochondrial inner membrane] (Plasmodium falciparum)

awd [mitochondrial inner membrane] (Drosophila melanogaster)

NME4 [mitochondrial inner membrane] (Bos taurus)

NME4 [mitochondrial inner membrane] (Caenorhabditis elegans)

NME4 [mitochondrial inner membrane] (Canis familiaris)

NME4 [mitochondrial inner membrane] (Plasmodium falciparum)

NME4 [mitochondrial inner membrane] (Sus scrofa)

Nme4 [mitochondrial inner membrane] (Mus musculus)

ndk-1 [mitochondrial inner membrane] (Caenorhabditis elegans)

ndkC-1; ndkC-2 [mitochondrial inner membrane] (Dictyostelium discoideum)

ndk1 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

nme4 [mitochondrial inner membrane] (Danio rerio)

nme4 [mitochondrial inner membrane] (Xenopus tropicalis)

ndkM [mitochondrial inner membrane] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001273369.1, NP_001273367.1, NP_001273368.1, NP_001273362.1, NP_001273364.1, NP_005000.1, NP_001273365.1

OpenTargets

ENSG00000103202

ENSEMBL

ENSP00000479996, ENST00000219479, ENSP00000389048, ENST00000620944, ENST00000450036, ENSG00000103202, ENSP00000380834, ENSP00000219479, ENST00000397722

IntEnz

2.7.4.6

HPA

ENSG00000103202-NME4

GeneCards

NME4

PRO

O00746

Pharos - Targets

O00746

GlyGen

O00746

PDB

1EHW

HMDB Protein

HMDBP00106

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.675	20
UniProt:Q9UMX1 SUFU	3	SUFU [ciliary base] (R-HSA-5610424) SUFU [cytosol] (R-HSA-445455) SUFU [ciliary tip] (R-HSA-5610426)	0.556	3
UniProt:P06858 LPL	1	LPL [extracellular region] (R-HSA-174605)	0.556	3
UniProt:P40692 MLH1	3	MLH1 [nucleoplasm] (R-HSA-912495) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 S252* [nucleoplasm] (R-HSA-5444526)	0.556	3
UniProt:Q9UBU9 NXF1	2	NXF1 [nucleoplasm] (R-HSA-111690) NXF1 [cytosol] (R-HSA-156481)	0.556	3
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.556	3
UniProt:O15160 POLR1C	2	POLR1C [cytosol] (R-HSA-1964454) POLR1C [nucleoplasm] (R-HSA-63498)	0.556	5
UniProt:Q9BZL1 UBL5	1	UBL5 [nucleoplasm] (R-HSA-9770255)	0.556	3
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340)	0.556	3
UniProt:Q9NPB3 CABP2	1	CABP2 [plasma membrane] (R-HSA-9672352)	0.556	3
UniProt:P01019 AGT	7	AGT(25-32) [extracellular region] (R-HSA-374187) AGT(25-34) [extracellular region] (R-HSA-2022346) AGT [extracellular region] (R-HSA-1998759) AGT(25-31) [extracellular region] (R-HSA-2022351) AGT(25-33) [extracellular region] (R-HSA-2022348) AGT(26-32) [extracellular region] (R-HSA-2022354) AGT(27-32) [extracellular region] (R-HSA-2022355)	0.556	3
UniProt:P03952 KLKB1	5	KLKB1(20-638) [plasma membrane] (R-HSA-158385) KLKB1(20-390) [plasma membrane] (R-HSA-158213) KLKB1(391-638) [plasma membrane] (R-HSA-158277) KLKB1(391-638) [extracellular region] (R-HSA-158181) KLKB1(20-390) [extracellular region] (R-HSA-158239)	0.556	3
UniProt:Q6DKK2 TTC19	1	TTC19 [mitochondrial inner membrane] (R-HSA-9906047)	0.556	3
UniProt:P02042 HBD	1	HBD [cytosol] (R-HSA-1008218)	0.556	3
UniProt:Q07954 LRP1	2	LRP1 [plasma membrane] (R-HSA-1454844) LRP1 [endocytic vesicle membrane] (R-HSA-2230981)	0.527	2
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-573) [cytosol] (R-HSA-1267989)	0.483	3

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