Reactome | NME4 [mitochondrial inner membrane]

NME4 [mitochondrial inner membrane]

Stable Identifier

R-HSA-60026

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

non-metastatic cells 4, protein expressed in, Nucleoside diphosphate kinase, mitochondrial, nm23-H4, NDP kinase, mitochondrial

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
10799505	The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase Janin, J, Capeau, J, Milon, L, Munier, A, Lacombe, ML, Karlsson, A, Lascu, I, Meyer, P, Johansson, M, Chiadmi, M	J Biol Chem	2000

External Reference Information

External Reference

UniProt:O00746 NME4

Gene Names

NME4, NM23D

Chain

transit peptide:1-28, chain:29-187

Reference Genes

BioGPS Gene:4833 NME4

COSMIC (genes):NME4 NME4

CTD Gene:4833 NME4

dbSNP Gene:4833 NME4

ENSEMBL:ENSG00000103202 NME4

ENSEMBL_homo_sapiens_GENE:ENSG00000103202.13 NME4

HGNC:7852 NME4

KEGG Gene (Homo sapiens):4833 NME4

Monarch:4833 NME4

NCBI Gene:4833 NME4

OMIM:601818 NME4

UCSC:O00746 NME4

Reference Transcript

Other Identifiers

11754486_a_at

212739_PM_s_at

212739_s_at

3642818

3642819

3642820

3642822

3642824

3642826

3642828

3642829

3642830

3642831

3642832

3642834

3642836

3642870

39089_at

4833

7991837

A_14_P136199

A_24_P210829

GE60243

GE86871

GO:0000166

GO:0003824

GO:0004550

GO:0005515

GO:0005524

GO:0005739

GO:0005743

GO:0005758

GO:0005759

GO:0006183

GO:0006228

GO:0006241

GO:0006869

GO:0008289

GO:0009116

GO:0009117

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0043226

GO:0046872

GO:0055086

GO:1901135

GO:1901612

HMNXSV003029418

Hs.9235.1.S1_3p_a_at

ILMN_1800634

PH_hs_0028747

PH_hs_0030972

Y07604_at

Participates

as a component of

NME4 hexamer [mitochondrial inner membrane] (Homo sapiens)

Inferred To

Homologues of NME4 [mitochondrial inner membrane] (Caenorhabditis elegans)

Homologues of NME4 [mitochondrial inner membrane] (Dictyostelium discoideum)

NME4 [mitochondrial inner membrane] (Bos taurus)

NME4 [mitochondrial inner membrane] (Caenorhabditis elegans)

NME4 [mitochondrial inner membrane] (Canis familiaris)

NME4 [mitochondrial inner membrane] (Dictyostelium discoideum)

NME4 [mitochondrial inner membrane] (Drosophila melanogaster)

NME4 [mitochondrial inner membrane] (Gallus gallus)

NME4 [mitochondrial inner membrane] (Mus musculus)

NME4 [mitochondrial inner membrane] (Plasmodium falciparum)

NME4 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

NME4 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

NME4 [mitochondrial inner membrane] (Sus scrofa)

ndk-1 [mitochondrial inner membrane] (Caenorhabditis elegans)

nme4 [mitochondrial inner membrane] (Danio rerio)

Cross References

RefSeq

NP_001273368.1, NP_001273362.1, NP_001273365.1, NP_001273364.1, NP_005000.1, NP_001273369.1, NP_001273367.1

OpenTargets

ENSG00000103202

IntEnz

2.7.4.6

GeneCards

O00746

HPA

ENSG00000103202-NME4

Ensembl

ENSP00000389048, ENST00000397722, ENSP00000219479, ENSG00000103202, ENSP00000380834, ENST00000620944, ENSP00000479996, ENST00000450036, ENST00000219479

PRO

O00746

Pharos - Targets

O00746

HMDB Protein

HMDBP00106

PDB

1EHW

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.675	20
UniProt:Q9BZL1 UBL5	1	UBL5 [nucleoplasm] (R-HSA-9770255)	0.556	3
UniProt:Q9NPB3 CABP2	1	CABP2 [plasma membrane] (R-HSA-9672352)	0.556	3
UniProt:P40692 MLH1	3	MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 [nucleoplasm] (R-HSA-912495)	0.556	3
UniProt:Q9UBU9 NXF1	2	NXF1 [cytosol] (R-HSA-156481) NXF1 [nucleoplasm] (R-HSA-111690)	0.556	3
UniProt:P01019 AGT	7	AGT(36-41) [extracellular region] (R-HSA-2022355) AGT(35-41) [extracellular region] (R-HSA-2022354) AGT(34-40) [extracellular region] (R-HSA-2022351) AGT(34-42) [extracellular region] (R-HSA-2022348) AGT [extracellular region] (R-HSA-1998759) AGT(34-43) [extracellular region] (R-HSA-2022346) AGT(34-41) [extracellular region] (R-HSA-374187)	0.556	3
UniProt:O15160 POLR1C	2	POLR1C [nucleoplasm] (R-HSA-63498) POLR1C [cytosol] (R-HSA-1964454)	0.556	5
UniProt:P03952 KLKB1	5	KLKB1(391-638) [plasma membrane] (R-HSA-158277) KLKB1(20-390) [plasma membrane] (R-HSA-158213) KLKB1(20-638) [plasma membrane] (R-HSA-158385) KLKB1(391-638) [extracellular region] (R-HSA-158181) KLKB1(20-390) [extracellular region] (R-HSA-158239)	0.556	3
UniProt:Q9UMX1 SUFU	3	SUFU [ciliary base] (R-HSA-5610424) SUFU [cytosol] (R-HSA-445455) SUFU [ciliary tip] (R-HSA-5610426)	0.556	3
UniProt:P02042 HBD	1	HBD [cytosol] (R-HSA-1008218)	0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:P20618 PSMB1	7	PSMB1(1-28) [cytosol] (R-HSA-9908143) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [cytosol] (R-HSA-68738)	0.556	3
UniProt:Q6DKK2 TTC19	1	TTC19 [mitochondrial inner membrane] (R-HSA-9906047)	0.556	3
UniProt:P06858 LPL	1	LPL [extracellular region] (R-HSA-174605)	0.556	3
UniProt:Q07954 LRP1	2	LRP1 [plasma membrane] (R-HSA-1454844) LRP1 [endocytic vesicle membrane] (R-HSA-2230981)	0.527	2
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171)	0.483	3

Cite Us!