Reactome | LSM3 [nucleoplasm]

LSM3 [nucleoplasm]

Stable Identifier

R-HSA-6806807

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

U6 snRNA-associated Sm-like protein LSm3, LSM3_HUMAN

Locations in the PathwayBrowser

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Metabolism of RNA (Homo sapiens)

- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - mRNA Splicing (Homo sapiens)
    - mRNA Splicing - Major Pathway (Homo sapiens)
      - Formation of the Spliceosomal B complex (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        U4:U5:U6 tri-snRNP complex [nucleoplasm] (Homo sapiens)
        
        U4 snRNP:U6 snRNP complex [nucleoplasm] (Homo sapiens)
        
        U6 snRNP [nucleoplasm] (Homo sapiens)
        
        LSM2-8 complex [nucleoplasm] (Homo sapiens)
        
        LSM3 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Bact complex (Homo sapiens)
        
        LSM2-8 complex [nucleoplasm] (Homo sapiens)
        
        LSM3 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Pre-B complex (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        U4:U5:U6 tri-snRNP complex [nucleoplasm] (Homo sapiens)
        
        U4 snRNP:U6 snRNP complex [nucleoplasm] (Homo sapiens)
        
        U6 snRNP [nucleoplasm] (Homo sapiens)
        
        LSM2-8 complex [nucleoplasm] (Homo sapiens)
        
        LSM3 [nucleoplasm] (Homo sapiens)
        
        U4:U5:U6 tri-snRNP complex [nucleoplasm] (Homo sapiens)
        
        U4 snRNP:U6 snRNP complex [nucleoplasm] (Homo sapiens)
        
        U6 snRNP [nucleoplasm] (Homo sapiens)
        
        LSM2-8 complex [nucleoplasm] (Homo sapiens)
        
        LSM3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62310 LSM3

Gene Names

LSM3, MDS017

Chain

initiator methionine:, chain:2-102

Reference Genes

BioGPS Gene:27258 LSM3

COSMIC (genes):LSM3 LSM3

CTD Gene:27258 LSM3

dbSNP Gene:27258 LSM3

ENSEMBL:ENSG00000170860 LSM3

HGNC:17874 LSM3

KEGG:hsa:27258 LSM3

Monarch:27258 LSM3

NCBI Gene:27258 LSM3

OMIM:607283 LSM3

UCSC:P62310 LSM3

Reference Transcript

RefSeq:NM_014463.2 LSM3

Other Identifiers

11716311_x_at

11753808_s_at

11753809_x_at

11757092_s_at

16937930

202209_PM_at

202209_at

236363_PM_at

236363_at

2562120

2611820

2611822

2611824

2611825

2611826

2611828

2611830

2611832

27258

39009_at

8078008

88333_at

A_14_P201409

A_23_P132863

A_23_P421563

A_24_P29001

A_33_P3792328

GE61318

GE706003

GO:0000398

GO:0000932

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005688

GO:0005829

GO:0006397

GO:0008380

GO:0016071

GO:0030629

GO:0032991

GO:0033962

GO:0043226

GO:0046540

GO:0071005

GO:0071011

GO:0071013

GO:0120115

GO:1990726

HMNXSV003013641

HMNXSV003049961

Hs.5020.0.A1_3p_at

ILMN_1719032

ILMN_2229242

PH_hs_0036881

PH_hs_0037646

TC03000085.hg

TC03002231.hg

g7657314_3p_at

p26226

Participates

as a component of

LSM2-8 complex [nucleoplasm] (Homo sapiens)

Other forms of this molecule

LSM3 [cytosol]

Inferred To

lsm3 [nucleoplasm] (Dictyostelium discoideum)

lsm3 [nucleoplasm] (Schizosaccharomyces pombe)

lsm3 [nucleoplasm] (Xenopus tropicalis)

lsm-3 [nucleoplasm] (Caenorhabditis elegans)

Lsm3 [nucleoplasm] (Mus musculus)

Lsm3 [nucleoplasm] (Rattus norvegicus)

LSm3 [nucleoplasm] (Drosophila melanogaster)

LSM3 [nucleoplasm] (Bos taurus)

LSM3 [nucleoplasm] (Canis familiaris)

LSM3 [nucleoplasm] (Gallus gallus)

LSM3 [nucleoplasm] (Plasmodium falciparum)

LSM3 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_055278.1

OpenTargets

ENSG00000170860

ENSEMBL

ENST00000306024, ENSP00000302160

HPA

ENSG00000170860-LSM3

PRO

P62310

Pharos - Targets

P62310

GlyGen

P62310

PDB

8H6J, 8R0B, 8H6L, 8QXD, 3JCR, 8R0A, 5O9Z, 6QW6, 8QO9, 8R09, 6AH0, 8QZS, 7ABG, 8H6K, 6AHD, 8H6E, 8RM5, 6QX9, 8R08

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62318 SNRPD3	3	2xMe-SNRPD3 [cytosol] (R-HSA-191781) 2xMe-SNRPD3 [nucleoplasm] (R-HSA-192219) SNRPD3 [nucleoplasm] (R-HSA-71903)	0.742	5
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.718	6
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.666	4
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.621	3
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.573	2
UniProt:P62308 SNRPG	2	SNRPG [cytosol] (R-HSA-191827) SNRPG [nucleoplasm] (R-HSA-71909)	0.547	2
UniProt:P62314 SNRPD1	3	2xMe-SNRPD1 [cytosol] (R-HSA-192217) SNRPD1 [cytosol] (R-HSA-191890) 2xMe-SNRPD1 [nucleoplasm] (R-HSA-192215)	0.547	2
UniProt:P62304 SNRPE	2	SNRPE [cytosol] (R-HSA-191782) SNRPE [nucleoplasm] (R-HSA-71905)	0.547	2