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p-S32,S36-YBX1 [nucleoplasm]
Stable Identifier
R-HSA-9733227
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
COL1A2 gene expression is stimulated by p-2S-SMAD3:p-2S-SMAD3:SMAD4 (Homo sapiens)
p-2S-SMAD3:p-2S-SMAD3:SMAD4:p-S-YBX1:COL1A2 gene [nucleoplasm] (Homo sapiens)
p-S32,S36-YBX1 [nucleoplasm] (Homo sapiens)
p-S32,S36-YBX1 [nucleoplasm] (Homo sapiens)
YBX1 binds COL1A2 gene promoter (Homo sapiens)
p-2S-SMAD3:p-2S-SMAD3:SMAD4:p-S-YBX1:COL1A2 gene [nucleoplasm] (Homo sapiens)
p-S32,S36-YBX1 [nucleoplasm] (Homo sapiens)
p-S32,S36-YBX1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
COL1A2 gene expression is stimulated by p-2S-SMAD3:p-2S-SMAD3:SMAD4 (Homo sapiens)
p-2S-SMAD3:p-2S-SMAD3:SMAD4:p-S-YBX1:COL1A2 gene [nucleoplasm] (Homo sapiens)
p-S32,S36-YBX1 [nucleoplasm] (Homo sapiens)
p-S32,S36-YBX1 [nucleoplasm] (Homo sapiens)
YBX1 binds COL1A2 gene promoter (Homo sapiens)
p-2S-SMAD3:p-2S-SMAD3:SMAD4:p-S-YBX1:COL1A2 gene [nucleoplasm] (Homo sapiens)
p-S32,S36-YBX1 [nucleoplasm] (Homo sapiens)
p-S32,S36-YBX1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P67809 YBX1
Gene Names
YBX1, NSEP1, YB1
Chain
initiator methionine:1, chain:2-324
Reference Genes
BioGPS Gene:4904 YBX1
COSMIC (genes):YBX1 YBX1
CTD Gene:4904 YBX1
dbSNP Gene:4904 YBX1
ENSEMBL:ENSG00000065978 YBX1
HGNC:8014 YBX1
KEGG Gene (Homo sapiens):4904 YBX1
Monarch:4904 YBX1
NCBI Gene:4904 YBX1
OMIM:154030 YBX1
UCSC:P67809 YBX1
Reference Transcript
RefSeq:NM_004559.4 YBX1
Other Identifiers
11756972_x_at
16663317
208627_PM_s_at
208627_s_at
208628_PM_s_at
208628_s_at
2332635
2332667
2332668
2332669
2332670
2332671
2332672
2332673
2332679
2332680
2332689
2332691
2332692
2332694
2332695
2332697
2332698
3066582
3066583
3066590
3205034
3205037
3205038
3205039
3205040
3205042
32340_s_at
3568965
3568967
3568969
4904
7900585
A_23_P34767
GE57491
GO:0000122
GO:0001701
GO:0003674
GO:0003676
GO:0003677
GO:0003682
GO:0003690
GO:0003697
GO:0003723
GO:0003729
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005689
GO:0005737
GO:0005783
GO:0005829
GO:0005886
GO:0006355
GO:0006397
GO:0006412
GO:0006810
GO:0006950
GO:0007568
GO:0008150
GO:0008380
GO:0008544
GO:0009056
GO:0009058
GO:0009790
GO:0010468
GO:0010494
GO:0017148
GO:0019899
GO:0030154
GO:0032991
GO:0034641
GO:0034655
GO:0035198
GO:0043226
GO:0043231
GO:0045944
GO:0048255
GO:0048598
GO:0048856
GO:0050658
GO:0051020
GO:0051031
GO:0051154
GO:0051301
GO:0051781
GO:0062153
GO:0070062
GO:0070934
GO:0070937
GO:0071204
GO:0098761
GO:1900152
GO:1903608
GO:1990124
GO:1990428
GO:1990837
GO:1990904
GO:2000767
GO:2000773
HMNXSV003006738
Hs.74497.1.S1_3p_a_at
Hs.74497.2.S1_3p_a_at
Hs.74497.2.S1_3p_x_at
ILMN_1669424
ILMN_2124769
J03827_at
PH_hs_0028962
TC01000531.hg
Participates
as a component of
p-2S-SMAD3:p-2S-SMAD3:SMAD4:p-S-YBX1:COL1A2 gene [nucleoplasm] (Homo sapiens)
as an input of
YBX1 binds COL1A2 gene promoter (Homo sapiens)
Other forms of this molecule
YBX1 [nucleoplasm]
YBX1 [extracellular region]
Inferred To
Homologues of p-S32,S36-YBX1 [nucleoplasm]
(Canis familiaris)
phospho-yps [nucleoplasm]
(Drosophila melanogaster)
phospho-Ybx1 [nucleoplasm]
(Mus musculus)
phospho-Ybx1 [nucleoplasm]
(Rattus norvegicus)
phospho-cey-1 [nucleoplasm]
(Caenorhabditis elegans)
phospho-ybx1 [nucleoplasm]
(Danio rerio)
phospho-ybx1 [nucleoplasm]
(Xenopus tropicalis)
phospho-LOC479011 [nucleoplasm]
(Canis familiaris)
phospho-YBX1 [nucleoplasm]
(Bos taurus)
phospho-YBX1 [nucleoplasm]
(Canis familiaris)
phospho-YBX1 [nucleoplasm]
(Gallus gallus)
phospho-YBX1 [nucleoplasm]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 32
Coordinate
32
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 36
Coordinate
36
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_004550.2
OpenTargets
ENSG00000065978
GeneCards
P67809
HPA
ENSG00000065978-YBX1
Ensembl
ENSG00000065978
,
ENST00000321358
,
ENSP00000361626
PRO
P67809
Pharos - Targets
P67809
PDB
6KTC
,
6KUG
,
6A6L
,
5YTV
,
5YTX
,
5YTS
,
5YTT
,
6LMR
,
6LMS
,
1H95
Interactors (55)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q07021 C1QBP
3
C1QBP [plasma membrane]
(R-HSA-158123)
C1QBP [mitochondrial matrix]
(R-HSA-9645697)
C1QBP [cytosol]
(R-HSA-9645690)
0.8
7
UniProt:O60506 HNRPQ
0.773
5
UniProt:O43390 HNRNPR
1
HNRNPR [nucleoplasm]
(R-HSA-71951)
0.708
4
UniProt:Q08211 DHX9
2
DHX9 [cytosol]
(R-HSA-847700)
DHX9 [nucleoplasm]
(R-HSA-53517)
0.702
10
UniProt:Q96EY7 PTCD3
1
PTCD3 [mitochondrial inner membrane]
(R-HSA-5368165)
0.669
3
UniProt:Q12906 ILF3
0.662
6
UniProt:Q12905 ILF2
4
ILF2 [specific granule lumen]
(R-HSA-6799611)
ILF2 [tertiary granule lumen]
(R-HSA-6800995)
ILF2 [extracellular region]
(R-HSA-6799684)
ILF2 [ficolin-1-rich granule lumen]
(R-HSA-6801001)
0.662
6
UniProt:Q7Z6M2 FBX33
0.641
6
UniProt:Q9Y6M1 IGF2BP2
1
IGF2BP2 [cytosol]
(R-HSA-428302)
0.63
6
UniProt:P16989 YBOX3
0.623
3
UniProt:P05455 SSB
1
SSB [nucleoplasm]
(R-HSA-58418)
0.623
3
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.623
3
UniProt:O00571 DDX3X
3
DDX3X [secretory granule lumen]
(R-HSA-6801275)
DDX3X [extracellular region]
(R-HSA-6806507)
DDX3X [ficolin-1-rich granule lumen]
(R-HSA-6801273)
0.613
6
UniProt:P19712-PRO_0000038050
0.599
4
UniProt:Q6PKG0 LARP1
1
LARP1 [cytosol]
(R-HSA-9760421)
0.597
5
UniProt:P26196 DDX6
1
DDX6 [cytosol]
(R-HSA-430032)
0.597
5
UniProt:Q99IB8-PRO_0000045599
0.577
3
UniProt:Q9NZI8 IGF2BP1
1
IGF2BP1 [cytosol]
(R-HSA-428366)
0.577
7
UniProt:P62310 LSM3
2
LSM3 [cytosol]
(R-HSA-429894)
LSM3 [nucleoplasm]
(R-HSA-6806807)
0.573
2
UniProt:P13693 TCTP
0.567
4
UniProt:P37108 SRP14
4
SRP14 [cytosol]
(R-HSA-264941)
SRP14 [secretory granule lumen]
(R-HSA-6800938)
SRP14 [extracellular region]
(R-HSA-6806495)
SRP14 [ficolin-1-rich granule lumen]
(R-HSA-6800439)
0.564
2
UniProt:Q13616 CUL1
3
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [nucleoplasm]
(R-HSA-187551)
CUL1 [cytosol]
(R-HSA-174230)
0.564
2
UniProt:Q9NUL7 DDX28
0.564
2
UniProt:Q96AG4 LRC59
0.564
2
UniProt:Q7L2E3 DHX30
0.564
2
UniProt:Q14694 USP10
3
USP10 [cytosol]
(R-HSA-6782974)
K63polyUb-USP10 [cytosol]
(R-HSA-6782986)
USP10 [nucleoplasm]
(R-HSA-3222218)
0.564
2
IntAct:EBI-6857440 NS3
0.558
3
UniProt:Q86U42 PABPN1
1
PABPN1 [nucleoplasm]
(R-HSA-72008)
0.558
4
UniProt:O95613 PCNT
8
PCNT [cytosol]
(R-HSA-380290)
PolyUb-Misfolded PCNT [late endosome lumen]
(R-HSA-9660016)
PCNT [cilium]
(R-HSA-9639683)
Misfolded PCNT [cilium]
(R-HSA-9639705)
Misfolded PCNT [cytosol]
(R-HSA-9640102)
Ub-Misfolded PCNT [cytosol]
(R-HSA-9641122)
PolyUb-Misfolded PCNT [cytosol]
(R-HSA-9641112)
PolyUb-Misfolded PCNT [lysosomal lumen]
(R-HSA-9660027)
0.556
4
UniProt:Q13148 TADBP
0.556
6
UniProt:P16403 H1-2
1
HIST1H1C [nucleoplasm]
(R-HSA-211237)
0.527
3
UniProt:Q9HCE1 MOV10
1
MOV10 [cytosol]
(R-HSA-427772)
0.527
2
UniProt:P33469 NCAP
0.527
3
UniProt:P38919 EIF4A3
2
EIF4A3 [cytosol]
(R-HSA-927868)
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
0.527
2
UniProt:P14866 HNRNPL
1
HNRNPL [nucleoplasm]
(R-HSA-71947)
0.527
3
UniProt:Q9UKV8 AGO2
2
EIF2C2 [nucleoplasm]
(R-HSA-5578701)
AGO2 [cytosol]
(R-HSA-209723)
0.527
3
UniProt:P49406 MRPL19
1
MRPL19 [mitochondrial inner membrane]
(R-HSA-5368215)
0.527
2
UniProt:Q9H361 PABP3
0.527
2
UniProt:Q14103-4 HNRNPD
2
Ub-HNRNPD-4 [cytosol]
(R-HSA-451232)
HNRNPD-4 [cytosol]
(R-HSA-450442)
0.527
3
UniProt:Q4G0J3 LARP7
0.527
2
UniProt:Q8WWM7 ATX2L
0.527
2
UniProt:Q13310 PABP4
0.527
2
UniProt:Q9NZB2 F120A
0.527
2
UniProt:P51398 DAP3
1
DAP3 [mitochondrial inner membrane]
(R-HSA-5368174)
0.527
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.527
10
UniProt:P11940 PABPC1
1
PABPC1 [cytosol]
(R-HSA-156803)
0.527
2
UniProt:P22626 HNRNPA2B1
2
HNRNPA2B1 [extracellular exosome]
(R-HSA-8950304)
HNRNPA2B1 [nucleoplasm]
(R-HSA-71929)
0.527
2
UniProt:Q09161 NCBP1
2
NCBP1 [nucleoplasm]
(R-HSA-51469)
NCBP1 [cytosol]
(R-HSA-162459)
0.527
4
IntAct:EBI-5333277 DSDNA
0.499
4
IntAct:EBI-5333321 DSDNA
0.499
3
UniProt:Q6ZN17 LN28B
0.499
2
UniProt:Q8NC51 PAIRB
0.499
2
IntAct:EBI-5333296 DSDNA
0.499
2
UniProt:O75526 RMXL2
0.499
2
UniProt:Q99697 PITX2
1
PITX2 [nucleoplasm]
(R-HSA-8864726)
0.499
3
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