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COG6 [trans-Golgi network membrane]
Stable Identifier
R-HSA-6813872
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
trans-Golgi network membrane
Synonyms
Conserved oligomeric Golgi complex subunit 6, COG6_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Retrograde transport at the Trans-Golgi-Network (Homo sapiens)
Fusion of early-endosome derived vesicles at the TGN (Homo sapiens)
COG complex [trans-Golgi network membrane] (Homo sapiens)
COG6 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
COG complex [trans-Golgi network membrane] (Homo sapiens)
COG6 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Homo sapiens)
COG complex [trans-Golgi network membrane] (Homo sapiens)
COG6 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
COG complex [trans-Golgi network membrane] (Homo sapiens)
COG6 [trans-Golgi network membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y2V7 COG6
Gene Names
COG6, KIAA1134
Chain
chain:1-657
Reference Genes
BioGPS Gene:57511 COG6
COSMIC (genes):COG6 COG6
CTD Gene:57511 COG6
dbSNP Gene:57511 COG6
ENSEMBL:ENSG00000133103 COG6
HGNC:18621 COG6
KEGG:hsa:57511 COG6
Monarch:57511 COG6
NCBI Gene:57511 COG6
OMIM:606977 COG6
UCSC:Q9Y2V7 COG6
Reference Transcript
RefSeq:NM_020751.2 COG6
RefSeq:NM_001145079.1 COG6
Other Identifiers
11724048_a_at
11724049_a_at
11739210_at
16774188
225769_PM_at
225769_at
232786_PM_at
232786_at
3486384
3486385
3486386
3486387
3486388
3486389
3486390
3486391
3486392
3486393
3486394
3486395
3486396
3486397
3486400
3486401
3486402
3486403
3486404
3486408
3486412
3486413
3486414
3486417
3486418
3486419
3486425
3486426
3486427
3486428
3486429
3486430
3486435
3486436
3486441
48586_at
57511
7968711
84000_at
A_14_P102773
A_14_P105706
A_14_P113837
A_23_P53866
A_24_P290692
GE79281
GE87975
GO:0000139
GO:0000301
GO:0005515
GO:0005794
GO:0006891
GO:0007030
GO:0015031
GO:0016020
GO:0016192
GO:0017119
GO:0032588
GO:0043226
GO:0070085
HMNXSV003035609
HMNXSV003046217
Hs.18282.0.S1_3p_at
Hs.18282.1.S1_3p_at
ILMN_1779530
PH_hs_0025461
PH_hs_0041065
TC13000137.hg
TC13001031.hg
Participates
as a component of
COG complex [trans-Golgi network membrane] (Homo sapiens)
Other forms of this molecule
COG6 [Golgi membrane]
Inferred To
cogc-6 [trans-Golgi network membrane]
(Caenorhabditis elegans)
cog6 [trans-Golgi network membrane]
(Dictyostelium discoideum)
COG6 [trans-Golgi network membrane]
(Bos taurus)
COG6 [trans-Golgi network membrane]
(Canis familiaris)
COG6 [trans-Golgi network membrane]
(Gallus gallus)
COG6 [trans-Golgi network membrane]
(Saccharomyces cerevisiae)
COG6 [trans-Golgi network membrane]
(Sus scrofa)
Cog6 [trans-Golgi network membrane]
(Drosophila melanogaster)
Cog6 [trans-Golgi network membrane]
(Mus musculus)
Cog6 [trans-Golgi network membrane]
(Rattus norvegicus)
Cross References
ENSEMBL
ENSP00000397441
,
ENST00000416691
,
ENSP00000348983
,
ENSP00000403733
,
ENST00000356576
,
ENSG00000133103
,
ENST00000455146
OpenTargets
ENSG00000133103
GeneCards
COG6
HPA
ENSG00000133103-COG6
PRO
Q9Y2V7
Pharos - Targets
Q9Y2V7
Orphanet
COG6
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95999 BCL10
3
K48polyUb-BCL10 [cytosol]
(R-HSA-8939329)
BCL10 [cytosol]
(R-HSA-202447)
p-BCL10 [cytosol]
(R-HSA-202488)
0.696
5
UniProt:Q96GM5 SMARCD1
1
SMARCD1 [nucleoplasm]
(R-HSA-389255)
0.556
3
UniProt:P47897 QARS1
2
QARS [cytosol]
(R-HSA-379615)
QARS [mitochondrial matrix]
(R-HSA-379592)
0.556
3
UniProt:P55081 MFAP1
1
MFAP1 [nucleoplasm]
(R-HSA-2396419)
0.556
3
UniProt:P20618 PSMB1
7
PSMB1 [cytosol]
(R-HSA-68738)
PSMB1 [nucleoplasm]
(R-HSA-174347)
pro-PSMB1 [cytosol]
(R-HSA-9908139)
PSMB1(1-28) [cytosol]
(R-HSA-9908143)
PSMB1 [ficolin-1-rich granule lumen]
(R-HSA-6803340)
PSMB1 [extracellular region]
(R-HSA-6806477)
PSMB1 [secretory granule lumen]
(R-HSA-6803287)
0.556
3
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.556
3
UniProt:P25786 PSMA1
2
PSMA1 [cytosol]
(R-HSA-68724)
PSMA1 [nucleoplasm]
(R-HSA-174333)
0.556
3
UniProt:Q9BV20 MRI1
1
MRI1 [cytosol]
(R-HSA-1237095)
0.556
3
UniProt:Q93034 CUL5
2
CUL5 [cytosol]
(R-HSA-180528)
G76-NEDD8-K724-CUL5 [cytosol]
(R-HSA-8952014)
0.556
3
UniProt:P55040 GEM
1
GEM [plasma membrane]
(R-HSA-9769962)
0.556
3
UniProt:O95863 SNAI1
1
SNAI1 [nucleoplasm]
(R-HSA-2980903)
0.556
3
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
0.527
2
UniProt:O43752 STX6
2
STX6 [trans-Golgi network membrane]
(R-HSA-6811007)
STX6 [Golgi membrane]
(R-HSA-6811004)
0.527
2
UniProt:Q9NWB7 IFT57
2
IFT57 [cilium]
(R-HSA-5610389)
IFT57 [ciliary tip]
(R-HSA-5625363)
0.527
2
UniProt:O00471 EXOC5
2
EXOC5 [cytosol]
(R-HSA-265045)
EXOC5 [cytosol]
(R-HSA-5623383)
0.527
2
UniProt:A1L190 SYCE3
1
SYCE3 [nucleoplasm]
(R-HSA-8867779)
0.527
3
UniProt:O15287 FANCG
2
FANCG [cytosol]
(R-HSA-420788)
FANCG [nucleoplasm]
(R-HSA-419532)
0.488
2
UniProt:O75791 GRAP2
1
GRAP2 [cytosol]
(R-HSA-202367)
0.488
2
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.488
2
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