Reactome | SRSF2 [nucleoplasm]

SRSF2 [nucleoplasm]

Stable Identifier

R-HSA-72033

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SR2 / SC35, Splicing factor, arginine/serine-rich 2, Splicing factor SC35, SC-35, Splicing component, 35 kDa, PR264 protein

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Dengue Virus Infection (Homo sapiens)
      - Dengue Virus-Host Interactions (Homo sapiens)
        
        NS5 interacts with Spliceosome (Homo sapiens)
        
        NS5:Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - Formation of pre-mRNPs (Homo sapiens)
    - Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
      - nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
      - Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
  - Transport of Mature Transcript to Cytoplasm (Homo sapiens)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
      - Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
        
        NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
        
        capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Homo sapiens)
        
        NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
        
        capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
  - mRNA 3'-end processing (Homo sapiens)
    - TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - Spliced mRNP [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
    - mRNA Polyadenylation (Homo sapiens)
      - CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS) (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - CPSF3 cleaves pre-mRNA at distal 3'UTR PAS (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - CPSF3 cleaves pre-mRNA at proximal 3'UTR PAS (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - Core CPA complex binds capped pre-mRNA (Homo sapiens)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Homo sapiens)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Homo sapiens)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Homo sapiens)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - PP1 dephosphorylates RNA Pol II (Homo sapiens)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - RBBP6 activates CPSF complex (Homo sapiens)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - Recruitment of other CPA components to pre-mRNA-bound CPA core (Homo sapiens)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - U1 snRNP suppresses CPSF3-mediated pre-mRNA cleavage at intronic PAS (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
  - mRNA Splicing (Homo sapiens)
    - mRNA Splicing - Major Pathway (Homo sapiens)
      - Formation of the Spliceosomal A complex (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal E complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal B complex (Homo sapiens)
        
        Spliceosomal B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal B* complex (Homo sapiens)
        
        Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Bact complex (Homo sapiens)
        
        Spliceosomal B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal C complex containing intron lariat (Homo sapiens)
        
        Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal C complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal C* complex (Homo sapiens)
        
        Spliceosomal C complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal E complex (Homo sapiens)
        
        Spliceosomal E complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
        
        Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal P complex [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Pre-B complex (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
        
        Spliceosomal P complex [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
    - mRNA Splicing - Minor Pathway (Homo sapiens)
      - ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Homo sapiens)
        
        ATAC C Complex with lariat containing 5'-end cleaved mRNA [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        post exon ligation complex [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Homo sapiens)
        
        ATAC C Complex [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        ATAC C Complex with lariat containing 5'-end cleaved mRNA [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - Formation of AT-AC A complex (Homo sapiens)
        
        ATAC A Complex [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - Formation of AT-AC B Complex (Homo sapiens)
        
        ATAC A Complex [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        ATAC B Complex [nucleoplasm] (Homo sapiens)
        
        ATAC A Complex [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
      - Formation of AT-AC C complex (Homo sapiens)
        
        ATAC B Complex [nucleoplasm] (Homo sapiens)
        
        ATAC A Complex [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)
        
        ATAC C Complex [nucleoplasm] (Homo sapiens)
        
        SRSF2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q01130 SRSF2

Gene Names

SRSF2, SFRS2

Chain

initiator methionine:1, chain:2-221

Reference Genes

BioGPS Gene:6427 SRSF2

COSMIC - genes:SRSF2 SRSF2

CTD Gene:6427 SRSF2

dbSNP Gene:6427 SRSF2

ENSEMBL:ENSG00000161547 SRSF2

HGNC:10783 SRSF2

KEGG:hsa:6427 SRSF2

Monarch:6427 SRSF2

NCBI Gene:6427 SRSF2

OMIM:600813 SRSF2

UCSC:Q01130 SRSF2

Reference Transcript

Other Identifiers

11734933_s_at

11749302_s_at

11761530_x_at

16849321

200753_PM_x_at

200753_x_at

200754_PM_x_at

200754_x_at

214882_PM_s_at

214882_s_at

36111_s_at

36112_r_at

3771797

3771799

3771801

3771802

3771803

3771804

3771805

3771806

3771807

3771808

3771809

3771810

3771811

3771812

3771813

3771814

3771815

3771816

3771817

3771818

6427

8018803

A_23_P77776

A_33_P3412945

GE58129

GO:0000381

GO:0003676

GO:0003714

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006355

GO:0006397

GO:0008380

GO:0016071

GO:0016607

GO:0045892

HMNXSV003033091

HMNXSV003041592

Hs.73965.0.A1_3p_s_at

Hs.73965.1.A1_3p_a_at

ILMN_1696407

PH_hs_0031303

TC17001908.hg

TC17002792.hg

X75755_rna1_s_at

Participates

as a component of

as an input of

Formation of AT-AC A complex (Homo sapiens)

as a member of

nonshuttling SRSFs [nucleoplasm] (Homo sapiens)

as an output of

Docking of the TAP:EJC Complex with the NPC (Homo sapiens)

Inferred To

Srsf2 [nucleoplasm] (Mus musculus)

Srsf2 [nucleoplasm] (Rattus norvegicus)

srsf2a [nucleoplasm] (Danio rerio)

Homologues of SRSF2 [nucleoplasm] (Danio rerio)

SC35 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of SRSF2 [nucleoplasm] (Canis familiaris)

Ghost homologue of SRSF2 [nucleoplasm] (Xenopus tropicalis)

SRSF2 [nucleoplasm] (Bos taurus)

SRSF2 [nucleoplasm] (Gallus gallus)

SRSF2 [nucleoplasm] (Sus scrofa)

rsp-4 [nucleoplasm] (Caenorhabditis elegans)

srsf2b [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_003007.2, NP_001182356.1

OpenTargets

ENSG00000161547

ENSEMBL

ENST00000392485, ENST00000452355, ENST00000359995, ENSP00000376276, ENST00000585202, ENSP00000353089, ENST00000508921, ENSP00000391278, ENSP00000462425, ENSG00000161547, ENSP00000441780

HPA

ENSG00000161547-SRSF2

GeneCards

SRSF2

PRO

Q01130

Pharos - Targets

Q01130

Orphanet

SRSF2

GlyGen

Q01130

PDB

2KN4, 2LEC, 2LEA, 2LEB

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.643	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-ESR1 [cytosol] (R-HSA-9632177) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.597	4
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.544	3
UniProt:Q86X95 CIR1			0.543	4
UniProt:Q96SB4 SRPK1	2	SRPK1 [cytosol] (R-HSA-9729349) SRPK1 [nucleoplasm] (R-HSA-9821984)	0.527	2
UniProt:Q92731 ESR2	5	ESR2 [cytosol] (R-HSA-9020970) ESR2 [nucleoplasm] (R-HSA-446165) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979)	0.527	2
UniProt:Q01081 U2AF1	1	U2AF1 [nucleoplasm] (R-HSA-71985)	0.519	3
UniProt:Q9HD47 RANGRF	1	RANGRF [cytosol] (R-HSA-5216063)	0.499	2
UniProt:Q9JKL7 SREK1			0.482	2
IntAct:EBI-17172839 LNCRN			0.463	3
UniProt:P19338 NCL	4	NCL [cytosol] (R-HSA-450514) NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.463	2

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