Reactome | SRSF2 [nucleoplasm]

SRSF2 [nucleoplasm]

Stable Identifier

R-HSA-72033

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SR2 / SC35, Splicing factor, arginine/serine-rich 2, Splicing factor SC35, SC-35, Splicing component, 35 kDa, PR264 protein

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q01130 SRSF2

Gene Names

SRSF2, SFRS2

Chain

initiator methionine:, chain:2-221

Reference Genes

BioGPS Gene:6427 SRSF2

COSMIC (genes):SRSF2 SRSF2

CTD Gene:6427 SRSF2

dbSNP Gene:6427 SRSF2

ENSEMBL:ENSG00000161547 SRSF2

ENSEMBL_homo_sapiens_GENE:ENSG00000161547.17 SRSF2

HGNC:10783 SRSF2

KEGG Gene (Homo sapiens):6427 SRSF2

Monarch:6427 SRSF2

NCBI Gene:6427 SRSF2

OMIM:600813 SRSF2

UCSC:Q01130 SRSF2

Reference Transcript

Other Identifiers

11734933_s_at

11749302_s_at

11761530_x_at

16849321

200753_PM_x_at

200753_x_at

200754_PM_x_at

200754_x_at

214882_PM_s_at

214882_s_at

36111_s_at

36112_r_at

3771797

3771799

3771801

3771802

3771803

3771804

3771805

3771806

3771807

3771808

3771809

3771810

3771811

3771813

3771814

3771815

3771816

3771817

3771818

6427

8018803

A_23_P77776

A_33_P3412945

GE58129

GO:0000228

GO:0000381

GO:0000398

GO:0003676

GO:0003714

GO:0003723

GO:0005080

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005694

GO:0005726

GO:0005829

GO:0006351

GO:0006355

GO:0006397

GO:0008380

GO:0016071

GO:0016607

GO:0033197

GO:0035061

GO:0036002

GO:0043226

GO:0045892

GO:0140110

HMNXSV003041592

Hs.73965.0.A1_3p_s_at

Hs.73965.1.A1_3p_a_at

ILMN_1696407

PH_hs_0031303

TC17001908.hg

TC17002792.hg

X75755_rna1_s_at

Participates

as a component of

as an input of

Formation of AT-AC A complex (Homo sapiens)

as a member of

nonshuttling SRSFs [nucleoplasm] (Homo sapiens)

as an output of

Docking of the TAP:EJC Complex with the NPC (Homo sapiens)

Inferred To

Srsf2 [nucleoplasm] (Mus musculus)

Srsf2 [nucleoplasm] (Rattus norvegicus)

SC35 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of SRSF2 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of SRSF2 [nucleoplasm] (Xenopus tropicalis)

SRSF2 [nucleoplasm] (Bos taurus)

SRSF2 [nucleoplasm] (Canis familiaris)

SRSF2 [nucleoplasm] (Gallus gallus)

SRSF2 [nucleoplasm] (Schizosaccharomyces pombe)

SRSF2 [nucleoplasm] (Sus scrofa)

rsp-4 [nucleoplasm] (Caenorhabditis elegans)

srsf2b [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_001182356.1, XP_016880431.1, NP_003007.2

OpenTargets

ENSG00000161547

GeneCards

Q01130

HPA

ENSG00000161547-SRSF2

Ensembl

ENST00000452355, ENSP00000462425, ENST00000585202, ENSP00000391278, ENSP00000376276, ENST00000508921, ENSP00000353089, ENST00000392485, ENSG00000161547, ENST00000359995, ENSP00000441780

PRO

Q01130

Pharos - Targets

Q01130

Orphanet

24947

PDB

2KN4, 2LEC, 2LEA, 2LEB

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.597	4
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.544	3
UniProt:Q86X95 CIR1			0.543	4
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.527	2
UniProt:Q96SB4 SRPK1	2	SRPK1 [nucleoplasm] (R-HSA-9821984) SRPK1 [cytosol] (R-HSA-9729349)	0.527	2
UniProt:Q92731 ESR2	5	PalmS-ESR2 [cytosol] (R-HSA-9020979) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.527	2
UniProt:Q01081 U2AF1	1	U2AF1 [nucleoplasm] (R-HSA-71985)	0.519	3
UniProt:Q9HD47 RANGRF	1	RANGRF [cytosol] (R-HSA-5216063)	0.499	2
UniProt:Q9JKL7 SREK1			0.482	2
IntAct:EBI-17172839 LNCRN			0.463	3
UniProt:P19338 NCL	3	NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.463	2

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