Reactome | Me-PalmS-ESR2 [plasma membrane]

Me-PalmS-ESR2 [plasma membrane]

Stable Identifier

R-HSA-9637787

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Estrogen receptor beta, ESR2_HUMAN

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External Reference Information

External Reference

UniProt:Q92731 ESR2

Gene Names

ESR2, ESTRB, NR3A2

Chain

chain:1-530

Reference Genes

COSMIC (genes):ESR2 ESR2

dbSNP Gene:2100 ESR2

ENSEMBL:ENSG00000140009 ESR2

Participates

as a candidate of

Me-PalmS-ESRs [plasma membrane] (Homo sapiens)

Other forms of this molecule

ESR2 [cytosol]

ESR2 [nucleoplasm]

PalmS-ESR2 [plasma membrane]

PalmS-ESR2 [cytosol]

Inferred To

esr2a [plasma membrane] (Danio rerio)

kni [plasma membrane] (Drosophila melanogaster)

knrl [plasma membrane] (Drosophila melanogaster)

esr2 [plasma membrane] (Xenopus tropicalis)

Homologues of Me-PalmS-ESR2 [plasma membrane] (Drosophila melanogaster)

Me-PalmS-ESR2 [plasma membrane] (Gallus gallus)

ESR2 [plasma membrane] (Bos taurus)

ESR2 [plasma membrane] (Canis familiaris)

ESR2 [plasma membrane] (Sus scrofa)

Esr2 [plasma membrane] (Mus musculus)

Esr2 [plasma membrane] (Rattus norvegicus)

eg [plasma membrane] (Drosophila melanogaster)

ERR [plasma membrane] (Drosophila melanogaster)

Modified Residues

Name

S-palmitoyl-L-cysteine at 399

Coordinate

399

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Name

omega-N-methyl-L-arginine at unknown position

PsiMod Name

omega-N-methyl-L-arginine

PsiMod Definition

A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine.

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29279 CTGF	1	CTGF [extracellular region] (R-HSA-561148)	0.626	5
UniProt:P60709 ACTB	5	ACTB [plasma membrane] (R-HSA-196016) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [cytosol] (R-HSA-201861) ACTB [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462)	0.597	6
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.597	3
UniProt:O43524 FOXO3	11	FOXO3 [nucleoplasm] (R-HSA-199305) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) FOXO3 [cytosol] (R-HSA-5687032) p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010)	0.591	4
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.532	3
UniProt:Q01130 SRSF2	1	SRSF2 [nucleoplasm] (R-HSA-72033)	0.527	2
UniProt:Q15149 PLEC	3	PLEC(2396-4684) [cytosol] (R-HSA-350618) PLEC(1-2395) [cytosol] (R-HSA-350638) PLEC [cytosol] (R-HSA-201575)	0.527	2
UniProt:Q9UQ35 SRRM2	1	SRRM2 [nucleoplasm] (R-HSA-8865888)	0.527	2
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.527	5
UniProt:Q13243 SRSF5	1	SRSF5 [nucleoplasm] (R-HSA-72028)	0.527	2
UniProt:P20930 FLG	2	FLG(?-?) [cytosol] (R-HSA-6810859) FLG(1-4061) [cytosol] (R-HSA-8849818)	0.527	2
UniProt:O14744 PRMT5	3	PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609) p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300)	0.527	3
UniProt:Q99460 PSMD1	4	PSMD1 [extracellular region] (R-HSA-6806194) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [cytosol] (R-HSA-68786)	0.527	2
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.527	5
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.527	3
UniProt:P12814 ACTN1	3	ACTN1 [cytosol] (R-HSA-354096) ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [extracellular region] (R-HSA-349722)	0.527	2
UniProt:Q60974 Ncor1	3	Ncor1 [cytosol] (R-MMU-1253324) Ncor1 [nucleoplasm] (R-MMU-442459) Ncor1 [nucleoplasm] (R-MMU-442501)	0.508	6
UniProt:P53041 PPP5C	2	PPP5C [nucleoplasm] (R-HSA-5683410) PPP5C [cytosol] (R-HSA-5675402)	0.508	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.499	8
UniProt:Q9BQG0 MYBBP1A	1	MYBBP1A [nucleoplasm] (R-HSA-5250650)	0.462	2
UniProt:Q9Y6Q9 NCOA3	2	p-S857 NCOA3 [nucleoplasm] (R-HSA-5687005) NCOA3 [nucleoplasm] (R-HSA-442488)	0.462	2
UniProt:O60264 SMARCA5	1	SMARCA5 [nucleoplasm] (R-HSA-417140)	0.462	2
UniProt:P62280 RPS11	2	RPS11 [cytosol] (R-HSA-72327) RPS11 [nucleoplasm] (R-HSA-6791212)	0.462	2
UniProt:P46781 RPS9	2	RPS9 [cytosol] (R-HSA-72387) RPS9 [nucleoplasm] (R-HSA-6790663)	0.462	2
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.462	2
UniProt:Q9Y4W2 LAS1L	1	LAS1L [nucleoplasm] (R-HSA-6791521)	0.462	2
UniProt:P50416 CPT1A	1	CPT1A [mitochondrial outer membrane] (R-HSA-400161)	0.462	2
UniProt:P62249 RPS16	2	RPS16 [cytosol] (R-HSA-72337) RPS16 [nucleoplasm] (R-HSA-6791196)	0.462	2
UniProt:P62277 RPS13	2	RPS13 [cytosol] (R-HSA-72331) RPS13 [nucleoplasm] (R-HSA-6791198)	0.462	2
UniProt:Q71UM5 RPS27L	2	RPS27L [nucleoplasm] (R-HSA-6791197) RPS27L [cytosol] (R-HSA-8868849)	0.462	2
UniProt:P48552 NRIP1	2	NRIP1 [nucleoplasm] (R-HSA-4086031) monoSUMO1-K756,K1154-NRIP1 [nucleoplasm] (R-HSA-4086057)	0.462	2
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.462	2
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.462	2
UniProt:Q9NVC6 MED17	1	MED17 [nucleoplasm] (R-HSA-212401)	0.462	2
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.462	2
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940)	0.462	2
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.462	2
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.462	2

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