Reactome | U2AF1 [nucleoplasm]

U2AF1 [nucleoplasm]

Stable Identifier

R-HSA-71985

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

U2AF 35 kDa subunit, U2AG_HUMAN, Splicing factor U2AF 35 kDa subunit, U2 auxiliary factor 35 kDa subunit, U2 snRNP auxiliary factor small subunit

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        U2AF1,U2AF1L4 [nucleoplasm] (Homo sapiens)
        
        U2AF1 [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        U2AF1,U2AF1L4 [nucleoplasm] (Homo sapiens)
        
        U2AF1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q01081 U2AF1

Gene Names

U2AF1, U2AF35, U2AFBP, FP793

Chain

initiator methionine:, chain:2-240

Reference Genes

BioGPS Gene:102724594 U2AF1

BioGPS Gene:7307 U2AF1

COSMIC (genes):U2AF1 U2AF1

CTD Gene:7307 U2AF1

dbSNP Gene:102724594 U2AF1

dbSNP Gene:7307 U2AF1

ENSEMBL:ENSG00000160201 U2AF1

ENSEMBL_homo_sapiens_GENE:ENSG00000160201.12 U2AF1

HGNC:12453 U2AF1

KEGG Gene (Homo sapiens):102724594 U2AF1

KEGG Gene (Homo sapiens):7307 U2AF1

Monarch:102724594 U2AF1

Monarch:7307 U2AF1

NCBI Gene:102724594 U2AF1

NCBI Gene:7307 U2AF1

OMIM:191317 U2AF1

UCSC:Q01081 U2AF1

Reference Transcript

Other Identifiers

102724594

11719965_s_at

11719966_x_at

202858_PM_at

202858_at

3339488

3588381

36517_at

3934000

3934001

3934003

3934004

3934006

3934008

3934010

3934014

3934018

3934019

3934020

3934024

3934025

7307

8070655

A_23_P6303

A_23_P6307

GE62289

GO:0000398

GO:0003676

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0006397

GO:0008380

GO:0015030

GO:0016071

GO:0016607

GO:0030628

GO:0043226

GO:0046872

GO:0050733

GO:0071013

GO:0089701

HMNXSV003052699

ILMN_2362368

M96982_at

g5803206_3p_at

Participates

as a member of

U2AF1,U2AF1L4 [nucleoplasm] (Homo sapiens)

Inferred To

U2af1 [nucleoplasm] (Mus musculus)

U2af1 [nucleoplasm] (Rattus norvegicus)

U2af38 [nucleoplasm] (Drosophila melanogaster)

uaf-2 [nucleoplasm] (Caenorhabditis elegans)

U2AF1 [nucleoplasm] (Bos taurus)

U2AF1 [nucleoplasm] (Canis familiaris)

U2AF1 [nucleoplasm] (Gallus gallus)

U2AF1 [nucleoplasm] (Plasmodium falciparum)

U2AF1 [nucleoplasm] (Schizosaccharomyces pombe)

U2AF1 [nucleoplasm] (Sus scrofa)

zgc:111896 [nucleoplasm] (Danio rerio)

u2af1 [nucleoplasm] (Dictyostelium discoideum)

u2af1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001307580.1, NP_001307575.1, NP_006749.1, NP_001020375.1, NP_001020374.1, NP_001307577.1

OpenTargets

ENSG00000160201

HPA

ENSG00000160201-U2AF1

GeneCards

Q01081

Ensembl

ENST00000380276, ENSG00000160201, ENSP00000420672, ENSP00000418705, ENSP00000291552, ENSP00000369629, ENST00000464750, ENST00000291552, ENST00000459639

PRO

Q01081

Pharos - Targets

Q01081

Orphanet

25013

PDB

1JMT

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26368 U2AF2	2	5OHK15,276-U2AF2 [nucleoplasm] (R-HSA-9630011) U2AF2 [nucleoplasm] (R-HSA-71987)	0.938	11
UniProt:Q8N4J0 CARNMT1	1	CARNMT1 [cytosol] (R-HSA-8876689)	0.666	6
UniProt:P61978 HNRNPK	2	polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.666	4
UniProt:P84103 SRSF3	1	SRSF3 [nucleoplasm] (R-HSA-72035)	0.659	4
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.618	4
UniProt:P40692 MLH1	3	MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 [nucleoplasm] (R-HSA-912495)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.527	2
UniProt:Q01130 SRSF2	1	SRSF2 [nucleoplasm] (R-HSA-72033)	0.519	3
UniProt:Q8N5F7 NKAP	1	NKAP [nucleoplasm] (R-HSA-9769602)	0.508	2
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.508	2
UniProt:Q6NYC1 JMJD6	1	JMJD6 [nucleoplasm] (R-HSA-4754226)	0.508	2
UniProt:P82979 SARNP	1	SARNP [nucleoplasm] (R-HSA-8849146)	0.471	3