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REPS1 [cytosol]
Stable Identifier
R-HSA-8862265
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
RalBP1-associated Eps domain-containing protein 1, REPS1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q8NFH8 REPS2
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
REPS1 [cytosol] (Homo sapiens)
FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)
REPS1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96D71 REPS1
Gene Names
REPS1
Chain
chain:1-796
Reference Genes
BioGPS Gene:85021 REPS1
COSMIC - genes:REPS1 REPS1
CTD Gene:85021 REPS1
dbSNP Gene:85021 REPS1
ENSEMBL:ENSG00000135597 REPS1
HGNC:15578 REPS1
KEGG:hsa:85021 REPS1
Monarch:85021 REPS1
NCBI Gene:85021 REPS1
OMIM:614825 REPS1
UCSC:Q96D71 REPS1
Reference Transcript
RefSeq:NM_001286611.2 REPS1
RefSeq:NM_031922.4 REPS1
RefSeq:NM_001128617.3 REPS1
RefSeq:NM_001286612.2 REPS1
Other Identifiers
11740152_a_at
11755156_a_at
17024227
224366_PM_s_at
224366_s_at
2976627
2976628
2976629
2976630
2976631
2976632
2976633
2976634
2976635
2976636
2976637
2976638
2976639
2976641
2976642
2976643
2976644
2976645
2976646
2976647
2976649
2976650
2976655
2976659
2976660
2976661
2976664
2976665
2976666
2976667
2976669
2976670
2976671
2976672
2976673
2976674
2976675
2976676
2976677
2976678
2976689
2976690
3674137
48119_at
62781_at
8129901
85021
A_23_P70748
GE512530
GE56144
GE83275
GO:0005509
GO:0005515
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0005905
GO:0006897
GO:0016020
GO:0016192
GO:0016197
GO:0017124
GO:0030674
GO:0046872
GO:0060090
HMNXSV003038847
HMNXSV003058309
ILMN_2222768
PH_hs_0023839
TC06002164.hg
g13625165_3p_s_at
Participates
as an output of
Dissociation of clathrin-associated proteins (Homo sapiens)
as a component of
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
as an input of
FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)
Inferred To
Reps [cytosol]
(Drosophila melanogaster)
LOC102156511 [cytosol]
(Canis familiaris)
Ghost homologue of REPS1 [cytosol]
(Caenorhabditis elegans)
REPS1 [cytosol]
(Bos taurus)
REPS1 [cytosol]
(Gallus gallus)
REPS1 [cytosol]
(Mus musculus)
REPS1 [cytosol]
(Sus scrofa)
reps1 [cytosol]
(Xenopus tropicalis)
Reps1 [cytosol]
(Rattus norvegicus)
eps15 [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001122089.1
,
NP_114128.3
,
NP_001273540.1
,
NP_001273541.1
OpenTargets
ENSG00000135597
ENSEMBL
ENST00000450536
,
ENSG00000135597
,
ENST00000409812
,
ENSP00000386699
,
ENST00000367663
,
ENSP00000258062
,
ENSP00000356635
,
ENST00000258062
,
ENSP00000392065
HPA
ENSG00000135597-REPS1
GeneCards
REPS1
PRO
Q96D71
Pharos - Targets
Q96D71
GlyGen
Q96D71
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15311 RALBP1
1
RALBP1 [cytosol]
(R-HSA-195194)
0.845
9
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.527
4
UniProt:P53680 AP2S1
4
AP2S1 [cytosol]
(R-HSA-182197)
AP2S1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130707)
AP2S1 [plasma membrane]
(R-HSA-389382)
AP2S1 [endolysosome membrane]
(R-HSA-6784821)
0.527
2
UniProt:Q8NFH8 REPS2
1
REPS2 [cytosol]
(R-HSA-432938)
0.527
3
UniProt:Q9UL42 PNMA2
0.527
2
UniProt:Q9NSY1 BMP2K
0.527
2
UniProt:Q2M2I8 AAK1
1
AAK1 [cytosol]
(R-HSA-8854795)
0.527
3
UniProt:P63010 AP2B1
4
AP2B1 [cytosol]
(R-HSA-182166)
AP2B1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130489)
AP2B1 [plasma membrane]
(R-HSA-167690)
AP2B1 [endolysosome membrane]
(R-HSA-6784827)
0.527
3
UniProt:P12273 PIP
1
PIP [extracellular region]
(R-HSA-5252061)
0.527
2
UniProt:Q15287 RNPS1
2
RNPS1 [cytosol]
(R-HSA-159256)
RNPS1 [nucleoplasm]
(R-HSA-156778)
0.527
2
UniProt:Q9QZS3-1 NUMB
0.499
3
UniProt:Q9QZS3-2 NUMB
0.499
2
UniProt:P49757 NUMB
1
NUMB [plasma membrane]
(R-HSA-443595)
0.499
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
0.483
7
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