Reactome | PolyUb-TP73 [cytosol]

PolyUb-TP73 [cytosol]

Stable Identifier

R-HSA-8957256

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PolyUb-p73

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O15350 TP73

Gene Names

TP73, P73

Chain

chain:1-636

Reference Genes

BioGPS Gene:7161 TP73

COSMIC (genes):TP73 TP73

CTD Gene:7161 TP73

dbSNP Gene:7161 TP73

ENSEMBL:ENSG00000078900 TP73

HGNC:12003 TP73

KEGG:hsa:7161 TP73

Monarch:7161 TP73

NCBI Gene:7161 TP73

OMIM:601990 TP73

UCSC:O15350 TP73

Reference Transcript

Participates

as a component of

PolyUb-TP73 tetramer [cytosol] (Homo sapiens)

Other forms of this molecule

TP73 [nucleoplasm]

TP73 [cytosol]

Inferred To

PolyUb-TP73 [cytosol] (Bos taurus)

PolyUb-TP73 [cytosol] (Danio rerio)

PolyUb-TP73 [cytosol] (Drosophila melanogaster)

PolyUb-TP73 [cytosol] (Gallus gallus)

PolyUb-TP73 [cytosol] (Mus musculus)

PolyUb-TP73 [cytosol] (Rattus norvegicus)

PolyUb-TP73 [cytosol] (Sus scrofa)

PolyUb-TP73 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

ubiquitinylated lysine (polyubiquitin chain [nucleoplasm]) at unknown position

Modification

polyubiquitin chain [nucleoplasm]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

OpenTargets

ENSG00000078900

ENSEMBL

ENSP00000367545, ENSP00000367534, ENSP00000367537, ENSP00000346423, ENSP00000474322, ENST00000378290, ENST00000354437, ENSP00000367539, ENST00000604074, ENST00000603362, ENSP00000474626, ENST00000378288, ENST00000378285, ENST00000378295, ENST00000604479, ENSG00000078900, ENSP00000475143

HPA

ENSG00000078900-TP73

GeneCards

TP73

PRO

O15350

Pharos - Targets

O15350

Orphanet

TP73

PDB

8P9D, 2WQI, 1DXS, 2XWC, 8P9C, 5KBD, 4GUQ, 2MPS, 4GUO, 3VD1, 3VD0, 3VD2, 2WTT, 6FGS, 2KBY, 6IJQ, 1COK, 4A63, 5HOB, 5HOC, 4G82, 2NB1, 4G83, 2WQJ, 8P9E, 7EZJ

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96J02 ITCH	2	ITCH [cytosol] (R-HSA-975995) Ub-C871-ITCH [cytosol] (R-HSA-8864515)	0.75	5
UniProt:P46937 YAP1	8	YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-Y407-YAP1 [cytosol] (R-HSA-9865208)	0.73	5
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.653	3
UniProt:Q9NZC7 WWOX	1	WWOX [cytosol] (R-HSA-1253335)	0.641	4
UniProt:P38646 HSPA9	6	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993)	0.637	11
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [nucleoplasm] (R-HSA-4655443) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.632	11
UniProt:P46934 NEDD4	1	NEDD4 [cytosol] (R-HSA-975992)	0.623	2
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.602	4
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.558	4
UniProt:Q9ESJ1 Cables1	3	Cables1 [nucleoplasm] (R-MMU-1013861) Cables1 [cytosol] (R-MMU-1013843) Cables1 [nucleoplasm] (R-MMU-1013870)	0.482	3

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