Reactome | p-5Y-NTRK3 [plasma membrane]

p-5Y-NTRK3 [plasma membrane]

Stable Identifier

R-HSA-9034718

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-5Y-TrKC, p-Y516,Y705,Y709,Y710,Y834-NTRK3, p-Y516,Y705,Y709,Y710,Y834-TRKC

Icon

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Homo sapiens)
        
        NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
        
        p-5Y-NTRK3 [plasma membrane] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Homo sapiens)
        
        NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
        
        p-5Y-NTRK3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16288 NTRK3

Gene Names

NTRK3, TRKC

Chain

signal peptide:1-31, chain:32-839

Reference Genes

BioGPS Gene:4916 NTRK3

COSMIC (genes):NTRK3 NTRK3

CTD Gene:4916 NTRK3

dbSNP Gene:4916 NTRK3

ENSEMBL:ENSG00000140538 NTRK3

HGNC:8033 NTRK3

KEGG:hsa:4916 NTRK3

Monarch:4916 NTRK3

NCBI Gene:4916 NTRK3

OMIM:191316 NTRK3

UCSC:Q16288 NTRK3

Reference Transcript

Other Identifiers

1059_at

1060_g_at

11727684_at

11727685_at

11740579_a_at

11752325_a_at

1557795_PM_s_at

1557795_s_at

206462_PM_s_at

206462_s_at

213960_PM_at

213960_at

215025_PM_at

215025_at

215115_PM_x_at

215115_x_at

215311_PM_at

215311_at

217033_PM_x_at

217033_x_at

217377_PM_x_at

217377_x_at

228849_PM_at

228849_at

32345_at

3637794

3637795

3637796

3637797

3637799

3637801

3637802

3637803

3637805

3637807

3637809

3637810

3637811

3637812

3637813

3637815

3637817

3637819

3637820

3637821

3637822

3637823

3637824

3637825

3637826

3637831

3637833

3637837

3637838

3637839

3637840

3637841

3637845

3637846

3637872

3637873

3637874

3637875

3637876

3637877

3637878

3637879

3637900

3637909

3637910

3637912

3637913

3637921

3637922

3637924

3637925

3637927

3637928

3637929

3637930

3637931

3637936

3637945

3637949

3637971

3637978

3637979

3637980

3637981

3637982

3637986

3637987

3637988

3637989

3637992

3637993

37839_at

39596_at

4916

7991186

80936_at

A_23_P205900

A_23_P88538

A_24_P810476

A_32_P141969

A_33_P3260134

A_33_P3322814

GE481796

GE58876

GO:0001933

GO:0001934

GO:0002039

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005030

GO:0005515

GO:0005524

GO:0005886

GO:0006468

GO:0007155

GO:0007156

GO:0007165

GO:0007169

GO:0007399

GO:0007411

GO:0007507

GO:0008284

GO:0010628

GO:0010976

GO:0016020

GO:0016301

GO:0016740

GO:0030154

GO:0030335

GO:0030424

GO:0032148

GO:0033138

GO:0038179

GO:0043121

GO:0043235

GO:0043406

GO:0046872

GO:0048856

GO:0050927

GO:0051896

GO:0051897

GO:0060089

GO:0070593

GO:0090630

GO:0098631

GO:0098632

GO:0140096

GO:1990090

HMNXSV003005264

HMNXSV003005684

HMNXSV003043601

HMNXSV003049040

HMNXSV003052405

Hs.113137.0.A1_3p_at

Hs.13223.0.S1_3p_at

Hs.169081.1.A1_3p_s_at

Hs.185701.0.S1_3p_at

Hs.26776.1.S1_3p_at

Hs2.436210.1.S1_3p_s_at

ILMN_1687967

ILMN_1734893

ILMN_1837429

ILMN_1872446

PH_hs_0002366

PH_hs_0021606

PH_hs_0038721

S76475_at

TC15001815.hg

TC15002689.hg

TC15002690.hg

U05012_s_at

p25943

Participates

as a component of

NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

NTRK3 [plasma membrane]

NTRK3(496-641) [cytosol]

NTRK3(496-641) [mitochondrial outer membrane]

NTRK3(642-839) [cytosol]

NTRK3(32-495) [plasma membrane]

Inferred To

Ghost homologue of p-5Y-NTRK3 [plasma membrane] (Xenopus tropicalis)

phospho-p-5Y-NTRK3 [plasma membrane] (Bos taurus)

phospho-p-5Y-NTRK3 [plasma membrane] (Gallus gallus)

phospho-p-5Y-NTRK3 [plasma membrane] (Mus musculus)

phospho-p-5Y-NTRK3 [plasma membrane] (Rattus norvegicus)

phospho-p-5Y-NTRK3 [plasma membrane] (Sus scrofa)

phospho-NTRK3 [plasma membrane] (Canis familiaris)

Modified Residues

Name

O4'-phospho-L-tyrosine at 516

Coordinate

516

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 705

Coordinate

705

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 709

Coordinate

709

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 710

Coordinate

710

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 834

Coordinate

834

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001307064.1, NP_001307063.1, NP_002521.2, XP_016877742.1, NP_001012338.1

Guide to Pharmacology - Targets

1819

ENSEMBL

ENST00000317501, ENSG00000140538, ENSP00000318328, ENSP00000511942, ENSP00000350356, ENST00000394480, ENST00000695462, ENSP00000485864, ENST00000357724, ENSP00000453959, ENST00000557856, ENSP00000377990, ENST00000629765

OpenTargets

ENSG00000140538

ZINC - FDA approved

NTRK3_HUMAN

ZINC - Substances

NTRK3_HUMAN

ZINC - Biogenic

NTRK3_HUMAN

ZINC target

Q16288

PRO

Q16288

GlyGen

Q16288

PDB

1WWC, 3V5Q, 4YMJ, 6KZD, 6KZC

ZINC - Investigational

NTRK3_HUMAN

IntEnz

2.7.10.1

GeneCards

NTRK3

HPA

ENSG00000140538-NTRK3

Pharos - Targets

Q16288

Orphanet

NTRK3

ZINC - Predictions - Purchasable

NTRK3_HUMAN

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18031 PTPN1	2	PTPN1 [endosome membrane] (R-HSA-9815895) PTPN1 [cytosol] (R-HSA-210625)	0.571	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.564	2
UniProt:Q6PKX4 DOK6	1	DOK6 [cytosol] (R-HSA-8855620)	0.548	3
UniProt:Q99523 SORT1	2	SORT1 [cytoplasmic vesicle membrane] (R-HSA-434221) SORT1 [Golgi membrane] (R-HSA-434332)	0.544	2
UniProt:Q16620 NTRK2	6	p-5Y-NTRK2 [plasma membrane] (R-HSA-9026475) NTRK2 [plasma membrane] (R-HSA-6798236) NTRK2 [Golgi membrane] (R-HSA-3008801) p-5Y-NTRK2 [Golgi membrane] (R-HSA-3008809) p-5Y,S479-NTRK2 [plasma membrane] (R-HSA-9032864) p-Y706,Y707-NTRK2 [plasma membrane] (R-HSA-9037044)	0.539	3
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.527	2
UniProt:Q13332 PTPRS	1	PTPRS [plasma membrane] (R-HSA-197680)	0.527	2
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.527	2
UniProt:P04439 HLA-A	9	HLA class I histocompatibility antigen, A-3 alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-983100) HLA class I histocompatibility antigen, A-3 alpha chain precursor [early endosome membrane] (R-HSA-1236826) HLA class I histocompatibility antigen, A-3 alpha chain precursor [plasma membrane] (R-HSA-197642) HLA class I histocompatibility antigen, A-3 alpha chain precursor [phagocytic vesicle membrane] (R-HSA-1236740) HLA class I histocompatibility antigen, A-3 alpha chain precursor [recycling endosome membrane] (R-HSA-8863889) HLA class I histocompatibility antigen, A-3 alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-983347) HLA class I histocompatibility antigen, A-3 alpha chain precursor [Golgi membrane] (R-HSA-983376) HLA-A A-3 [endoplasmic reticulum membrane] (R-HSA-8943090) K48polyUb-HLA-A A-2 [endoplasmic reticulum membrane] (R-HSA-8943073)	0.527	2
UniProt:P04629 NTRK1	4	p-5Y-NTRK1 [plasma membrane] (R-HSA-3009413) NTRK1 [plasma membrane] (R-HSA-3008784) NTRK1 [Golgi membrane] (R-HSA-3008805) p-5Y-NTRK1 [Golgi membrane] (R-HSA-3008810)	0.499	2
UniProt:P61619 SEC61A1	2	SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591) SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813)	0.499	2
UniProt:Q16832 DDR2	1	DDR2 [plasma membrane] (R-HSA-211419)	0.499	2
UniProt:Q9UBV2 SEL1L	1	SEL1L [endoplasmic reticulum membrane] (R-HSA-1911545)	0.499	2
UniProt:Q15375 EPHA7	2	p-Y608,Y614-EPHA7 [plasma membrane] (R-HSA-3928358) EPHA7 [plasma membrane] (R-HSA-2682337)	0.499	2
UniProt:P08581 MET	7	p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973) MET [plasma membrane] (R-HSA-419603) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032)	0.499	2
UniProt:A8MVW0 F1712			0.483	2

Cite Us!