Reactome | PTPN1 [cytosol]

PTPN1 [cytosol]

Stable Identifier

R-HSA-210625

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PTP1B, Protein-tyrosine phosphatase 1B

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P18031 PTPN1

Gene Names

PTPN1, PTP1B

Chain

chain:1-435

Reference Genes

BioGPS Gene:5770 PTPN1

COSMIC (genes):PTPN1 PTPN1

CTD Gene:5770 PTPN1

dbSNP Gene:5770 PTPN1

ENSEMBL:ENSG00000196396 PTPN1

ENSEMBL_homo_sapiens_GENE:ENSG00000196396.10 PTPN1

HGNC:9642 PTPN1

KEGG Gene (Homo sapiens):5770 PTPN1

Monarch:5770 PTPN1

NCBI Gene:5770 PTPN1

OMIM:176885 PTPN1

UCSC:P18031 PTPN1

Reference Transcript

Other Identifiers

11717146_at

11717147_a_at

16914844

16914859

202716_PM_at

202716_at

3888722

3888723

3888724

3888725

3888747

3888751

3888753

3888755

3888761

3888762

3888764

3888766

3888767

3888769

3888770

3888772

3888773

3888774

3888775

3888776

3888777

3888778

3888783

3888785

40137_at

5770

588_at

591_s_at

8063394

A_14_P115470

A_23_P338890

GE57927

GO:0002376

GO:0003723

GO:0003824

GO:0004721

GO:0004725

GO:0004726

GO:0005158

GO:0005515

GO:0005737

GO:0005739

GO:0005759

GO:0005768

GO:0005769

GO:0005783

GO:0005789

GO:0005829

GO:0005886

GO:0006470

GO:0006886

GO:0007010

GO:0008270

GO:0008286

GO:0009966

GO:0009968

GO:0012501

GO:0016020

GO:0016192

GO:0016311

GO:0016787

GO:0016791

GO:0019899

GO:0019901

GO:0023052

GO:0030036

GO:0030061

GO:0030100

GO:0030948

GO:0030968

GO:0030971

GO:0031410

GO:0031904

GO:0032991

GO:0033157

GO:0034620

GO:0034976

GO:0035335

GO:0035791

GO:0036211

GO:0036498

GO:0038020

GO:0043226

GO:0043407

GO:0043507

GO:0045296

GO:0046626

GO:0046627

GO:0046875

GO:0051721

GO:0060338

GO:0060397

GO:0061098

GO:0070373

GO:0097443

GO:0098542

GO:0098554

GO:0140096

GO:1902202

GO:1902236

GO:1903896

GO:1903898

GO:1990264

GO:2000646

HMNXSV003018706

ILMN_1681591

M31724_at

M33684_s_at

PH_hs_0025079

TC20000403.hg

TC20000405.hg

g4506288_3p_at

Participates

as a component of

as an input of

as an output of

as a member of

Other forms of this molecule

PTPN1 [endosome membrane]

Inferred To

Ghost homologue of PTPN1 [cytosol] (Danio rerio)

PTPN1 [cytosol] (Bos taurus)

PTPN1 [cytosol] (Canis familiaris)

PTPN1 [cytosol] (Drosophila melanogaster)

PTPN1 [cytosol] (Gallus gallus)

PTPN1 [cytosol] (Mus musculus)

PTPN1 [cytosol] (Rattus norvegicus)

PTPN1 [cytosol] (Sus scrofa)

PTPN1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_002818.1, NP_001265547.1

ZINC - World Drugs

PTN1_HUMAN

Guide to Pharmacology - Targets

2976

OpenTargets

ENSG00000196396

ZINC - FDA approved

PTN1_HUMAN

ZINC - Substances

PTN1_HUMAN

ZINC - Biogenic

PTN1_HUMAN

ZINC target

P18031

PRO

P18031

PDB

5QEF, 7FRS, 2CNI, 7GT1, 5QDW, 5QF0, 7GU6, 7GSK, 5QE8, 7GU3, 1T4J, 7GTZ, 1QXK, 7FQV, 5QG8, 5QF6, 1NZ7, 7FQY, 5QEE, 1G7F, 3SME, 2CM3, 5QES, 2CMC, 7KEN, 7L0C, 7LFO, 7GS7, 5KA3, 1Q1M, 7S4F, 5QE5, 6XED, 2QBP, 5QFH, 7FQS, 7GSY, 2F70, 8EYA, 7FRH, 7GTY, 5QFN, 4QBW, 5QFU, 5T19, 8XOY, 5QET, 8G6A, 3A5J, 5QE3, 2HNQ, 2F6V, 5QEH, 5QFF, 7GTE, 5QF7, 7GTJ, 5KAC, 1T48, 2CMA, 6PG0, 8DU7, 5QDP, 2CNG, 5QG4, 7FRF, 1Q6S, 1LQF, 3ZV2, 6PGT, 5QFC, 5QE1, 8EYB, 7GTR, 2FJM, 6XEG, 7GSV, 3I80, 5QEG, 1NNY, 6B8E, 7GTD, 7GSR, 3EU0, 5QDN, 7MOW, 5K9W, 3CWE, 7GSE, 5QEN, 1G1G, 5QG1, 5QEW, 7FQP, 5QGC, 7MNB, 8F88, 1OEO, 7KEY, 2F6Y, 7GT8, 7GTQ, 7KLX, 7GU9, 1G1H, 6OLQ, 2HNP, 7RIN, 7GTL, 1C86, 6NTP, 5KA7, 7GTS, 1EEO, 2H4G, 1Q6P, 2CNF, 5QDY, 5QEP, 6B8X, 5QG3, 6PM8, 7GSX, 3ZMP, 7GSM, 2VEX, 2ZMM, 8U1E, 5QEB, 5QGE, 1AAX, 5QG0, 5QFP, 2BGD, 7FQX, 2VEV, 5QDF, 5QDV, 7GTA, 5K9V, 2F6T, 5QFG, 4I8N, 1SUG, 6XEA, 5QFJ, 5QDI, 8G65, 5QE7, 1OEM, 5QGB, 2HB1, 5QF2, 7FQR, 7FRE, 1PA1, 7GU1, 7GSU, 5KA1, 1OEV, 1XBO, 5QDT, 5QEA, 7GTN, 5QFE, 7FRK, 5QED, 2B4S, 5QEV, 5QF9, 7GSD, 6PFW, 8G67, 1OET, 5QEM, 5QDR, 5QEZ, 7FRN, 2AZR, 7GT7, 7MNA, 7FRQ, 5QG6, 5QFY, 2NTA, 7GSQ, 7GTM, 7GT4, 1PYN, 7FRU, 7GSG, 1PH0, 1C84, 8EXK, 1PTU, 7GU5, 5QEY, 1C83, 8EYC, 7GSA, 3EAX, 7MND, 5QFR, 2CM8, 3ZMQ, 7GTT, 6B8Z, 7FQM, 5QEC, 5QGF, 7GSJ, 3QKQ, 1NL9, 7GU7, 7GTC, 7FQO, 5KA2, 7MKZ, 8EXN, 5QG7, 7GTP, 7GTU, 5QFQ, 6OL4, 2CNH, 1GFY, 7MNF, 1OES, 7FQZ, 5QDX, 2ZN7, 1L8G, 7GT9, 7MOU, 5QF1, 1PXH, 2F6Z, 5QE9, 3D9C, 5QG5, 7FRG, 1NWE, 5QFM, 3A5K, 4ZRT, 7GTO, 5QFX, 7MN9, 6W30, 5QE4, 2CM2, 5QG2, 5KA4, 6OLV, 7GTB, 6B8T, 7GTI, 5QFI, 7GUC, 7GSC, 7GST, 7GT6, 6BAI, 5QF5, 5QER, 5QFL, 6OMY, 7GT3, 1C85, 7GSF, 2F6W, 2H4K, 7FRJ, 1ONZ, 1Q6T, 5QF8, 8G69, 1T49, 1NWL, 6PHA, 7FRP, 5QEX, 8EXJ, 5QFB, 2B07, 5QE0, 7MNC, 1BZJ, 6PHS, 5KA9, 6CWV, 7GU0, 7FQU, 7MM1, 2QBS, 5QDM, 5KAB, 7GU8, 2CMB, 7GTV, 1G1F, 7FRM, 5KAD, 1A5Y, 1KAV, 8EXI, 7MOV, 6XEF, 7GSL, 7GT0, 5QEO, 1G7G, 7FRR, 2FJN, 5QDK, 7GS9, 5QFT, 1PTY, 5QE2, 3I7Z, 7GTX, 1ONY, 7FRT, 2QBR, 5QEJ, 7FQN, 7MN7, 2NT7, 6B90, 7GU4, 1BZH, 1WAX, 5QDH, 5QE6, 1JF7, 5KA8, 1KAK, 6B95, 5QDZ, 5QEQ, 7FQW, 4BJO, 7GUB, 6CWU, 1Q6M, 5KAA, 5QDU, 7GTW, 5QFO, 7GTF, 5QEU, 5QEI, 6XE8, 7GS8, 7GTK, 1C87, 5QDG, 7GSN, 7GT2, 5QFZ, 5QFS, 3EB1, 1C88, 5QDJ, 1PTT, 7GSB, 7FRO, 5QF3, 7GSH, 7FRI, 1Q6J, 1PTV, 5QFK, 5QDS, 7GUA, 5QDL, 2BGE, 5QFW, 1BZC, 5QGA, 5QDO, 8G68, 5QEL, 7GSZ, 4QBE, 7GSO, 8SKL, 2CNE, 4Y14, 7FQT, 5QGD, 7GU2, 7GTH, 5QDQ, 2VEY, 2F71, 4QAP, 5QFA, 1NO6, 7GSI, 5QF4, 5QFD, 7L0H, 1EEN, 2VEW, 3QKP, 5QDE, 5QEK, 2VEU, 7GT5, 1I57, 8EXM, 7FQQ, 2QBQ, 5QG9, 7FRL, 7MNE, 7GTG, 7GSW, 2F6F, 6XEE, 2CM7, 5KA0, 1OEU, 1ECV, 5QFV, 4QAH, 1Q6N

ZINC - Investigational

PTN1_HUMAN

ZINC - Metabolites

PTN1_HUMAN

HPA

ENSG00000196396-PTPN1

GeneCards

P18031

Ensembl

ENSG00000196396, ENST00000371621, ENSP00000360683

Pharos - Targets

P18031

ZINC - Predictions - Purchasable

PTN1_HUMAN

HMDB Protein

HMDBP08931

Interactors (52)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06213 INSR	6	p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(763-1382) [endosome membrane] (R-HSA-141722) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.98	33
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.937	14
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.898	9
UniProt:O60674 JAK2	8	p-Y1007,Y1008-JAK2 [cytosol] (R-HSA-9005327) p-JAK2 [cytosol] (R-HSA-210621) p-Y813-JAK2 [cytosol] (R-HSA-997248) JAK2 V617F [nucleoplasm] (R-HSA-5211269) JAK2 [endosome lumen] (R-HSA-2002372) p-12Y-JAK2 [cytosol] (R-HSA-2586516) p-Y1007-JAK2 [cytosol] (R-HSA-873799) JAK2 [cytosol] (R-HSA-210620)	0.819	5
UniProt:P56945 BCAR1	4	p-Y-BCAR1 [cytosol] (R-HSA-372645) p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) BCAR1 [cytosol] (R-HSA-201625)	0.786	5
UniProt:Q61140 Bcar1	6	phospho-Bcar1 [cytosol] (R-MMU-372645) p-12Y-P130Cas [cytosol] (R-MMU-5218727) Bcar1 [cytosol] (R-MMU-201625) phospho-Bcar1 [cytosol] (R-MMU-8848723) phospho-Bcar1 [cytosol] (R-MMU-5218739) p130Cas [cytosol] (R-MMU-5218743)	0.756	5
UniProt:Q9H1D0 TRPV6	1	TRPV6 [plasma membrane] (R-HSA-937289)	0.744	6
UniProt:P09619 PDGFRB	3	p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039) PDGFRB [plasma membrane] (R-HSA-186767) p-12Y-PDGFRB [plasma membrane] (R-HSA-186803)	0.713	3
UniProt:P08581 MET	7	p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032) MET [plasma membrane] (R-HSA-419603) p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973)	0.713	3
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [early endosome membrane] (R-HSA-5368451)	0.697	5
UniProt:P08069 IGF1R	3	IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.688	4
UniProt:P07384 CAPN1	4	CAPN1 [plasma membrane] (R-HSA-3828038) CAPN1 [cytosol] (R-HSA-3288367) CAPN1 [extracellular region] (R-HSA-6806485) CAPN1 [ficolin-1-rich granule lumen] (R-HSA-6801284)	0.676	4
UniProt:P05622	3	phospho-p-11Y-PDGFRB [plasma membrane] (R-MMU-8864039) PDGFRB [plasma membrane] (R-MMU-186767) phospho-p-12Y-PDGFRB [plasma membrane] (R-MMU-186803)	0.656	3
UniProt:P10912 GHR	7	p-Y332,Y487,Y627-GHR(19-638) [plasma membrane] (R-HSA-1169226) GHR(257-638) [plasma membrane] (R-HSA-1168803) p-5Y-GHR(19-638) [plasma membrane] (R-HSA-1168904) GHR(19-638) [endosome lumen] (R-HSA-1169263) GHR(19-256) [extracellular region] (R-HSA-1168821) GHR(19-638) [plasma membrane] (R-HSA-982779) GHR activated [plasma membrane] (R-HSA-1168385)	0.645	5
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.642	4
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.623	2
ChEBI:17440 4-NITROPHENYL DIHYDROGEN PHOSPHATE			0.623	2
UniProt:Q96GX1 TCTN2	1	TCTN2 [ciliary membrane] (R-HSA-5626661)	0.615	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	11
UniProt:P19235 EPOR	2	EPOR [plasma membrane] (R-HSA-1168347) p-8Y-EPOR [plasma membrane] (R-HSA-9006274)	0.602	3
UniProt:P11274-1 BCR			0.602	3
UniProt:Q63767	4	phospho-Bcar1 [cytosol] (R-RNO-372645) phospho-Bcar1 [cytosol] (R-RNO-5218739) phospho-Bcar1 [cytosol] (R-RNO-8848723) Bcar1 [cytosol] (R-RNO-201625)	0.591	5
UniProt:O43561 LAT	3	p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829) LAT [plasma membrane] (R-HSA-202322) p-5Y-LAT [plasma membrane] (R-HSA-202364)	0.591	3
UniProt:P62994 Grb2	3	Grb2 [cytosol] (R-RNO-55929) Grb2 [plasma membrane] (R-RNO-202993) Grb2 [cytosol] (R-RNO-74686)	0.589	3
UniProt:Q63768 Crk	2	Crk [cytosol] (R-RNO-2980677) Crk [cytosol] (R-RNO-110017)	0.589	2
UniProt:Q16288 NTRK3	6	NTRK3(32-495) [plasma membrane] (R-HSA-9603541) NTRK3(642-839) [cytosol] (R-HSA-9603540) NTRK3(496-641) [mitochondrial outer membrane] (R-HSA-9603557) NTRK3(496-641) [cytosol] (R-HSA-9603542) NTRK3 [plasma membrane] (R-HSA-6798240) p-5Y-NTRK3 [plasma membrane] (R-HSA-9034718)	0.571	2
UniProt:Q96TC7 RMD3			0.568	4
UniProt:Q9WUD9 Src	11	MyrG,p-Y419-Src [plasma membrane] (R-RNO-9037057) SRC [cytosol] (R-RNO-9628701) phospho-p-Y419-SRC [cytosol] (R-RNO-8964276) MyrG-SRC [plasma membrane] (R-RNO-8876922) MyrG-p-Y419-Src [plasma membrane] (R-RNO-8937901) phospho-p-Y419-SRC-1 [plasma membrane] (R-RNO-112331) phospho-p-Y419-SRC [cytosol] (R-RNO-377592) phospho-MyrG,p-Y530-SRC [plasma membrane] (R-RNO-377598) SRC_RAT [cytosol] (R-RNO-548926) phospho-MyrG-p-Y419-SRC [plasma membrane] (R-RNO-1810408) SRC-1 [plasma membrane] (R-RNO-65043)	0.564	2
UniProt:P42229 STAT5A	4	STAT5A [nucleoplasm] (R-HSA-9701901) p-Y694-STAT5A [nucleoplasm] (R-HSA-507995) p-Y694-STAT5A [cytosol] (R-HSA-507936) STAT5A [cytosol] (R-HSA-380747)	0.558	2
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:Q96HV5 TM41A			0.556	3
UniProt:Q9GZR5 ELOVL4	1	ELOVL4 [endoplasmic reticulum membrane] (R-HSA-548705)	0.556	3
IntAct:EBI-22326698 CCSB ORF ID			0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:P57054 PIGP	1	PIGP(26-158) [endoplasmic reticulum membrane] (R-HSA-162761)	0.556	3
UniProt:P10686 Plcg1	8	p-4Y-Plcg1 [plasma membrane] (R-RNO-9034825) phospho-p-Y771,Y783-PLCG1 [plasma membrane] (R-RNO-1169084) phospho-p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-RNO-202357) p-Plcg1 [plasma membrane] (R-RNO-182042) Plcg1 [plasma membrane] (R-RNO-182093) PLCG1 [plasma membrane] (R-RNO-167682) PLCG1 [cytosol] (R-RNO-202320) phospho-p-4Y-PLCG1 [plasma membrane] (R-RNO-167679)	0.556	4
UniProt:Q9NPL8 TIMMDC1	1	TIMMDC1 [mitochondrial inner membrane] (R-HSA-5689720)	0.556	3
UniProt:Q99679 GPR21			0.527	2
UniProt:Q9H3K2 GHITM			0.527	3
UniProt:O94886 TMEM63A	3	TMEM63A [specific granule membrane] (R-HSA-6799721) TMEM63A [plasma membrane] (R-HSA-6800445) TMEM63A [tertiary granule membrane] (R-HSA-6800945)	0.527	3
UniProt:O00461 GOLIM4	2	GOLIM4 [transport vesicle] (R-HSA-8847524) GOLIM4 [Golgi membrane] (R-HSA-8847523)	0.527	2
UniProt:Q8IZF4 AGRG5			0.527	2
UniProt:A2RU67 F234B			0.527	2
UniProt:Q9P296 C5AR2	1	C5AR2 [plasma membrane] (R-HSA-964798)	0.527	2
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	2
UniProt:Q16581 C3AR1	3	C3AR1 [plasma membrane] (R-HSA-444727) C3AR1 [azurophil granule membrane] (R-HSA-6799517) C3AR1 [specific granule membrane] (R-HSA-6799516)	0.527	2
UniProt:Q63HN8 RNF213	3	RNF213(1-1172)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9715284) RNF213(1-1172)-ALK(1058-1620) fusion [cytosol] (R-HSA-9715291) RNF213 [cytosol] (R-HSA-9635613)	0.527	2
UniProt:P35570 Irs1	7	Irs1 [cytosol] (R-RNO-1168867) phospho-Irs1 [plasma membrane] (R-RNO-2445090) Irs1 [plasma membrane] (R-RNO-2425392) p-Y-Irs1 [cytosol] (R-RNO-112362) Irs1 [cytosol] (R-RNO-74769) phospho-Irs1 [cytosol] (R-RNO-74772) phospho-Irs1 [plasma membrane] (R-RNO-198366)	0.525	3
UniProt:P15116	3	CDH2 [plasma membrane] (R-MMU-191429) phospho-p-CDH2 [endoplasmic reticulum lumen] (R-MMU-8956899) CDH2 [endoplasmic reticulum lumen] (R-MMU-8956761)	0.524	3
UniProt:P05106 ITGB3	3	p-T779-ITGB3 [plasma membrane] (R-HSA-432107) ITGB3(27-?) [platelet alpha granule membrane] (R-HSA-114512) ITGB3 [plasma membrane] (R-HSA-57600)	0.499	4
UniProt:P02730 SLC4A1	8	SLC4A1 R589H [plasma membrane] (R-HSA-5657833) SLC4A1 G701D [plasma membrane] (R-HSA-5657836) SLC4A1 E90K [plasma membrane] (R-HSA-5657855) SLC4A1 S613F [plasma membrane] (R-HSA-5657854) SLC4A1 R589C [plasma membrane] (R-HSA-5657843) SLC4A1 V488M [plasma membrane] (R-HSA-5657845) SLC4A1 V850del [plasma membrane] (R-HSA-5657828) SLC4A1 [plasma membrane] (R-HSA-420408)	0.499	2
UniProt:P05787 KRT8	1	KRT8 [cytosol] (R-HSA-446043)	0.463	2

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