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p-T365,S369,T577-RPS6KA3 [cytosol]
Stable Identifier
R-HSA-9619959
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phospho(T365,S369,T577)-Ribosomal protein S6 kinase alpha 3, p-T365,S369,T577-RSK2
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
RSK activation (Homo sapiens)
ERKs phosphorylate RSKs (Homo sapiens)
p-T359,S363,T573-RSK [cytosol] (Homo sapiens)
p-T365,S369,T577-RPS6KA3 [cytosol] (Homo sapiens)
RSKs autophosphorylate (Homo sapiens)
p-T359,S363,T573-RSK [cytosol] (Homo sapiens)
p-T365,S369,T577-RPS6KA3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51812 RPS6KA3
Gene Names
RPS6KA3, ISPK1, MAPKAPK1B, RSK2
Chain
chain:1-740
Reference Genes
BioGPS Gene:6197 RPS6KA3
COSMIC (genes):RPS6KA3 RPS6KA3
CTD Gene:6197 RPS6KA3
dbSNP Gene:6197 RPS6KA3
ENSEMBL:ENSG00000177189 RPS6KA3
HGNC:10432 RPS6KA3
KEGG:hsa:6197 RPS6KA3
Monarch:6197 RPS6KA3
NCBI Gene:6197 RPS6KA3
OMIM:300075 RPS6KA3
UCSC:P51812 RPS6KA3
Reference Transcript
RefSeq:NM_004586.2 RPS6KA3
Other Identifiers
11742811_at
11742812_a_at
17109716
203843_PM_at
203843_at
226335_PM_at
226335_at
33229_at
4002174
4002175
4002176
4002177
4002178
4002179
4002180
4002181
4002182
4002184
4002189
4002190
4002191
4002192
4002194
4002196
4002199
4002201
4002202
4002203
4002205
4002211
4002212
4002214
4002218
4002219
4002221
4002224
4002225
4002226
4002227
4002228
4002230
4002233
4002238
4002239
4002240
4002241
46959_at
51906_at
6197
8171762
865_at
A_32_P517749
GE79413
GE87121
GO:0000287
GO:0001501
GO:0002224
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004711
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0005840
GO:0006355
GO:0006468
GO:0007165
GO:0007268
GO:0007417
GO:0016740
GO:0018105
GO:0019901
GO:0023052
GO:0030307
GO:0032496
GO:0035556
GO:0043027
GO:0043066
GO:0043226
GO:0043555
GO:0045202
GO:0045597
GO:0045944
GO:0046872
GO:0048856
GO:0098772
GO:0106310
GO:0140096
HMNXSV003041000
HMNXSV003046361
Hs.173965.0.S2_3p_at
Hs.188361.0.S1_3p_at
ILMN_1652736
ILMN_1770822
ILMN_1806294
PH_hs_0022897
TC0X000911.hg
U08316_at
Participates
as a member of
p-T359,S363,T573-RSK [cytosol] (Homo sapiens)
Other forms of this molecule
p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm]
p-T365,S369,S386,T577,T737-RPS6KA3 [cytosol]
p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol]
RPS6KA3 [cytosol]
p-4S,T231,T365-RPS6KA3 [nucleoplasm]
RPS6KA3 [nucleoplasm]
Modified Residues
Name
O-phospho-L-threonine at 365
Coordinate
365
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 369
Coordinate
369
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 577
Coordinate
577
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_004577.1
ZINC - World Drugs
KS6A3_HUMAN
Guide to Pharmacology - Targets
1528
OpenTargets
ENSG00000177189
ENSEMBL
ENST00000379565
,
ENSP00000368884
ZINC - FDA approved
KS6A3_HUMAN
ZINC - Substances
KS6A3_HUMAN
ZINC - Biogenic
KS6A3_HUMAN
ZINC target
P51812
PRO
P51812
GlyGen
P51812
PDB
4NUS
,
8XEY
,
4NW5
,
4D9U
,
4JG8
,
4D9T
,
4JG7
,
4JG6
,
5D9L
,
5D9K
,
8EQ5
,
8XFY
,
7OPO
,
4NW6
ZINC - Investigational
KS6A3_HUMAN
HPA
ENSG00000177189-RPS6KA3
Pharos - Targets
P51812
Orphanet
RPS6KA3
ZINC - Predictions - Purchasable
KS6A3_HUMAN
HMDB Protein
HMDBP01443
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P28482 MAPK1
18
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
MAPK1 [cytosol]
(R-HSA-59282)
MAPK1 [nucleoplasm]
(R-HSA-199960)
p-T185-MAPK1 [cytosol]
(R-HSA-9635773)
p-T185,Y187 MAPK1 P58G [cytosol]
(R-HSA-9652802)
p-T185,Y187 MAPK1 E322A [cytosol]
(R-HSA-9652794)
p-T185,Y187 MAPK1 D321N [cytosol]
(R-HSA-9652785)
p-T185,Y187 MAPK1 D321V [cytosol]
(R-HSA-9652791)
p-T185,Y187 MAPK1 P58L [cytosol]
(R-HSA-9652806)
p-T185,Y187 MAPK1 S142L [cytosol]
(R-HSA-9652808)
p-T185,Y187 MAPK1 E81K [cytosol]
(R-HSA-9652799)
p-T185,Y187 MAPK1 E322K [cytosol]
(R-HSA-9652175)
p-T185,Y187 MAPK1 E322V [cytosol]
(R-HSA-9652797)
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
MAPK1 [endoplasmic reticulum lumen]
(R-HSA-9636293)
0.878
12
UniProt:Q15418 RPS6KA1
7
p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm]
(R-HSA-444292)
p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619993)
p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619871)
p-T359,S363,T573-RPS6KA1 [cytosol]
(R-HSA-9619957)
RPS6KA1 [cytosol]
(R-HSA-444256)
p-4S,T359,T573-RPS6KA1 [nucleoplasm]
(R-HSA-199829)
RPS6KA1 [nucleoplasm]
(R-HSA-199860)
0.788
6
UniProt:P21802 FGFR2
20
FGFR2 IIIa TM [extracellular region]
(R-HSA-8851703)
FGFR2 [plasma membrane]
(R-HSA-2023840)
FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
(R-HSA-8853137)
FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane]
(R-HSA-8853154)
FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane]
(R-HSA-8853123)
FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane]
(R-HSA-8853158)
FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane]
(R-HSA-8853150)
FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane]
(R-HSA-8853153)
FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane]
(R-HSA-8853139)
FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane]
(R-HSA-8853159)
FGFR2 N549H [plasma membrane]
(R-HSA-2033296)
FGFR2 N549K [plasma membrane]
(R-HSA-1637910)
FGFR2 K660N [plasma membrane]
(R-HSA-1637905)
p-8Y-FGFR2 K660M [plasma membrane]
(R-HSA-2033300)
p-8Y-FGFR2 K660E [plasma membrane]
(R-HSA-2033298)
phosphorylated FGFR2 L764Hfs*4 [plasma membrane]
(R-HSA-2071957)
p-8Y-FGFR2 W290C [plasma membrane]
(R-HSA-2029875)
p-8Y-FGFR2 S267P [plasma membrane]
(R-HSA-2029879)
p-8Y-FGFR2 [plasma membrane]
(R-HSA-2029874)
p-8Y-FGFR2 N549K [plasma membrane]
(R-HSA-2033306)
0.745
5
UniProt:P11362 FGFR1
9
FGFR1 [plasma membrane]
(R-HSA-9756433)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
0.671
4
UniProt:P27361 MAPK3
6
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
MAPK3 [cytosol]
(R-HSA-59284)
MAPK3 [nucleoplasm]
(R-HSA-73724)
p-T202-MAPK3 [cytosol]
(R-HSA-9635775)
MAPK3 [endoplasmic reticulum lumen]
(R-HSA-9636295)
0.615
5
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.564
3
UniProt:Q12849 GRSF1
2
GRSF1 [mitochondrial matrix]
(R-HSA-9837006)
GRSF1 [cytosol]
(R-HSA-192689)
0.527
2
UniProt:Q8WUM4 PDCD6IP
1
PDCD6IP [cytosol]
(R-HSA-917717)
0.527
2
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