Reactome | p-8Y-FGFR1 N546K [plasma membrane]

p-8Y-FGFR1 N546K [plasma membrane]

Stable Identifier

R-HSA-2023358

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by FGFR in disease (Homo sapiens)
    - Signaling by FGFR1 in disease (Homo sapiens)
      - Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
      - Activated FGFR1 mutants and fusions bind PLCG1 (Homo sapiens)
        
        Activated FGFR1 mutants and fusions [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants and fusions:PLCG1 [cytosol] (Homo sapiens)
        
        Activated FGFR1 mutants and fusions [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
      - Activated FGFR1 mutants and fusions phosphorylate PLCG1 (Homo sapiens)
        
        Activated FGFR1 mutants and fusion:p-PLCG1 [cytosol] (Homo sapiens)
        
        Activated FGFR1 mutants and fusions [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants and fusions:PLCG1 [cytosol] (Homo sapiens)
        
        Activated FGFR1 mutants and fusions [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
      - Activated FGFR1 mutants bind FRS2 (Homo sapiens)
        
        Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants:FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
      - Activated FGFR1 mutants phosphorylate FRS2 (Homo sapiens)
        
        Activated FGFR1 mutants:FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
      - Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)
        
        Activated FGFR1 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
        
        FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
      - Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
        
        Activated FGFR1 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
      - Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)
        
        Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
      - Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
        
        FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
      - FGFR1 mutant receptor activation (Homo sapiens)
        
        Signaling by activated point mutants of FGFR1 (Homo sapiens)
        
        Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity (Homo sapiens)
        
        Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
      - p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions (Homo sapiens)
        
        Activated FGFR1 mutants and fusion:p-PLCG1 [cytosol] (Homo sapiens)
        
        Activated FGFR1 mutants and fusions [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants and fusions [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P11362 FGFR1

Gene Names

FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR

Chain

signal peptide:1-21, chain:22-822

Reference Genes

BioGPS Gene:2260 FGFR1

COSMIC (genes):FGFR1 FGFR1

CTD Gene:2260 FGFR1

dbSNP Gene:2260 FGFR1

ENSEMBL:ENSG00000077782 FGFR1

ENSEMBL:ENSG00000077782.23 FGFR1

HGNC:3688 FGFR1

KEGG Gene (Homo sapiens):2260 FGFR1

Monarch:2260 FGFR1

NCBI Gene:2260 FGFR1

OMIM:136350 FGFR1

UCSC:P11362 FGFR1

Reference Transcript

Other Identifiers

11716548_x_at

11727300_a_at

11727301_a_at

11734765_a_at

11747416_a_at

11747417_x_at

2056_at

2057_g_at

207937_PM_x_at

207937_x_at

211535_PM_s_at

211535_s_at

2260

226705_PM_at

226705_at

3132013

3132015

3132017

3132018

3132019

3132020

3132021

3132022

3132023

3132025

3132026

3132027

3132028

3132029

3132031

3132033

3132036

3132039

3132041

3132044

3132046

3132055

3132056

3132070

3132072

3132076

3132078

3132080

3132081

3132083

3132095

3132108

3132109

3132111

3132112

3132113

3132114

3132115

3132116

3493097

36168_at

424_s_at

53212_at

8150318

91005_at

A_23_P301304

A_23_P372923

A_24_P4171

GE59934

GO:0000165

GO:0000166

GO:0001501

GO:0001764

GO:0001837

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005007

GO:0005515

GO:0005524

GO:0005576

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006468

GO:0007165

GO:0007169

GO:0008201

GO:0008284

GO:0008543

GO:0010518

GO:0010863

GO:0012501

GO:0014068

GO:0016020

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0017134

GO:0018108

GO:0023052

GO:0030154

GO:0031410

GO:0033674

GO:0036211

GO:0042802

GO:0042803

GO:0043009

GO:0043226

GO:0043235

GO:0043406

GO:0043410

GO:0043536

GO:0045595

GO:0045597

GO:0045666

GO:0046777

GO:0048015

GO:0048513

GO:0048705

GO:0048856

GO:0048870

GO:0051897

GO:0060089

GO:0071363

GO:0090722

GO:0140096

GO:1905564

GO:2000546

GO:2001239

HMNXSV003006005

HMNXSV003036243

Hs.748.8.A1_3p_at

ILMN_1729369

ILMN_1796229

ILMN_2398261

PH_hs_0000085

X66945_at

g13186246_3p_a_at

g182560_3p_a_at

Participates

as a component of

p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]

FGFR1 K656E [plasma membrane]

FGFR1 N546K [plasma membrane]

FGFR1 R576W [plasma membrane]

p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]

p-8Y-FGFR1 K656E [plasma membrane]

p-8Y- FGFR1 R576W [plasma membrane]

FGFR1 [plasma membrane]

Modified Residues

Name

O4'-phospho-L-tyrosine at 766

Coordinate

766

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 463

Coordinate

463

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 583

Coordinate

583

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 585

Coordinate

585

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 653

Coordinate

653

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 654

Coordinate

654

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 730

Coordinate

730

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 776

Coordinate

776

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

L-asparagine 546 replaced with L-lysine

Coordinate

546

PsiMod

L-lysine residue [MOD:00021]

A protein modification that effectively converts a source amino acid residue to L-lysine.

L-asparagine removal [MOD:01633]

A protein modification that effectively removes or replaces an L-asparagine.

Disease

Name	Identifier	Synonyms
glioblastoma	DOID:3068	spongioblastoma multiforme, Spongioblastoma multiforme, primary glioblastoma multiforme, Glioblastoma multiforme, Glioblastoma (morphologic abnormality), GBM (Glioblastoma), Glioblastoma NOS (morphologic abnormality)
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Cross References

RefSeq

NP_001167538.1, NP_075594.1, NP_001167535.1, NP_075593.1, NP_056934.2, NP_075598.2, NP_001167536.1, NP_001167534.1, NP_001167537.1

ZINC - World Drugs

FGFR1_HUMAN

Guide to Pharmacology - Targets

1808

OpenTargets

ENSG00000077782

ZINC - FDA approved

FGFR1_HUMAN

ZINC - Substances

FGFR1_HUMAN

ZINC - Biogenic

FGFR1_HUMAN

ZINC target

P11362

PRO

P11362

PDB

6P68, 5O4A, 6C19, 3OJV, 4NKA, 4RWJ, 3DPK, 3TT0, 1CVS, 4UWB, 3GQI, 5A46, 5AM6, 1EVT, 5EW8, 6ITJ, 4F65, 6C18, 4WUN, 3RHX, 4NKS, 6NVL, 2FGI, 4NK9, 5A4C, 5W59, 4RWI, 6C1B, 4F64, 4V04, 7OZB, 6C1C, 4F63, 4V01, 3KY2, 3KRJ, 1FQ9, 5AM7, 3C4F, 5ZV2, 7OZD, 5VND, 4V05, 5FLF, 3KXX, 3JS2, 6C1O, 4RWL, 6MZW, 1FGI, 4ZSA, 3GQL, 6P69, 5Z0S, 1AGW, 5O49, 5W21, 2CR3, 7OZF, 1XR0, 5UQ0, 4UWC, 3KRL, 5B7V, 4UWY, 5UR1, 4RWK, 7WCL, 6MZQ, 1FGK

ZINC - Investigational

FGFR1_HUMAN

IntEnz

2.7.10.1

HPA

ENSG00000077782-FGFR1

GeneCards

P11362

Ensembl

ENSP00000348537, ENSP00000337247, ENSP00000327229, ENSP00000432972, ENST00000397113, ENST00000397108, ENSG00000077782, ENST00000447712, ENST00000356207, ENSP00000380280, ENSP00000380297, ENST00000532791, ENSP00000400162, ENST00000397091, ENST00000326324, ENST00000335922, ENSP00000380302, ENST00000484370, ENSP00000433163

Pharos - Targets

P11362

Orphanet

16046

ZINC - Predictions - Purchasable

FGFR1_HUMAN

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09038 FGF2	1	FGF2(10-155) [extracellular region] (R-HSA-189898)	0.912	9
UniProt:P19174 PLCG1	6	p-Y-PLCG1 [cytosol] (R-HSA-9029082) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [plasma membrane] (R-HSA-167682) PLCG1 [cytosol] (R-HSA-202320) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084)	0.903	11
UniProt:P05230 FGF1	1	FGF1 [extracellular region] (R-HSA-189856)	0.789	4
UniProt:P46934 NEDD4	1	NEDD4 [cytosol] (R-HSA-975992)	0.672	26
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.669	3
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.644	6
UniProt:Q8IVI9 NOSTRIN	2	NOSTRIN [endocytic vesicle membrane] (R-HSA-535014) NOSTRIN [plasma membrane] (R-HSA-202134)	0.633	5
UniProt:P23352 ANOS1	1	KAL1 [extracellular region] (R-HSA-5654345)	0.626	7
UniProt:P11362 FGFR1	9	FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) FGFR1 [plasma membrane] (R-HSA-9756433)	0.623	4
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.623	3
UniProt:P08908 HTR1A	1	HTR1A [plasma membrane] (R-HSA-390971)	0.62	9
UniProt:P10686 Plcg1	8	p-4Y-Plcg1 [plasma membrane] (R-RNO-9034825) phospho-p-Y771,Y783-PLCG1 [plasma membrane] (R-RNO-1169084) phospho-p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-RNO-202357) PLCG1 [cytosol] (R-RNO-202320) p-Plcg1 [plasma membrane] (R-RNO-182042) Plcg1 [plasma membrane] (R-RNO-182093) PLCG1 [plasma membrane] (R-RNO-167682) phospho-p-4Y-PLCG1 [plasma membrane] (R-RNO-167679)	0.611	4
UniProt:P51812 RPS6KA3	7	RPS6KA3 [nucleoplasm] (R-HSA-199869) p-4S,T231,T365-RPS6KA3 [nucleoplasm] (R-HSA-199830) RPS6KA3 [cytosol] (R-HSA-444250) p-T365,S369,T577-RPS6KA3 [cytosol] (R-HSA-9619959) p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619872) p-T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619989) p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm] (R-HSA-444286)	0.569	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.569	4
UniProt:Q8WU20 FRS2	6	p-Y-FRS2 [cytosol] (R-HSA-162551) FRS2 [cytosol] (R-HSA-190244) p-6Y-FRS2 [cytosol] (R-HSA-190355) p-8T-FRS2 [plasma membrane] (R-HSA-1270462) FRS2 [plasma membrane] (R-HSA-170963) p-6Y-FRS2 [plasma membrane] (R-HSA-170959)	0.569	3
UniProt:O35082	2	Kl [plasma membrane] (R-MMU-190198) Kl [extracellular region] (R-MMU-190201)	0.558	2
UniProt:Q9GZV9 FGF23	6	p-FGF23 [endoplasmic reticulum lumen] (R-HSA-8957077) FGF23 [endoplasmic reticulum lumen] (R-HSA-8956697) FGF23(25-251) [Golgi lumen] (R-HSA-8851630) GalNAc-T178-FGF23(25-251) [Golgi lumen] (R-HSA-8851624) FGF23(25-251) [extracellular region] (R-HSA-189891) GalNAc-T178-FGF23(25-251) [extracellular region] (R-HSA-8851633)	0.544	2
UniProt:P22455 FGFR4	12	FGFR4 Y367C [plasma membrane] (R-HSA-1614439) FGFR4 N535K [plasma membrane] (R-HSA-1614430) FGFR4 V550E [plasma membrane] (R-HSA-1614433) FGFR4 V550L [plasma membrane] (R-HSA-1614436) FGFR4 N535D [plasma membrane] (R-HSA-1614427) p-5Y-FGFR4 V550E [plasma membrane] (R-HSA-2038932) p-5Y-FGFR4 N535K [plasma membrane] (R-HSA-2038931) p-5Y-FGFR4 V550L [plasma membrane] (R-HSA-2038935) p-5Y-FGFR4 N535D [plasma membrane] (R-HSA-2038934) p5Y-FGFR4 Y367C mutant [plasma membrane] (R-HSA-2011873) FGFR4 [plasma membrane] (R-HSA-189921) p-5Y-FGFR4 [plasma membrane] (R-HSA-190330)	0.539	3
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.536	3
UniProt:P21802 FGFR2	20	FGFR2 IIIa TM [extracellular region] (R-HSA-8851703) FGFR2 [plasma membrane] (R-HSA-2023840) FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane] (R-HSA-8853137) FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane] (R-HSA-8853154) FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane] (R-HSA-8853123) FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane] (R-HSA-8853158) FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane] (R-HSA-8853150) FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane] (R-HSA-8853153) FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane] (R-HSA-8853139) FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane] (R-HSA-8853159) FGFR2 N549H [plasma membrane] (R-HSA-2033296) FGFR2 N549K [plasma membrane] (R-HSA-1637910) FGFR2 K660N [plasma membrane] (R-HSA-1637905) FGFR2 K660M [plasma membrane] (R-HSA-1637902) FGFR2 K660E [plasma membrane] (R-HSA-1637900) FGFR2 S267P [plasma membrane] (R-HSA-1637920) FGFR2 L764Hfs*4 [plasma membrane] (R-HSA-1637908) FGFR2 W290C [plasma membrane] (R-HSA-1637929) p-6Y-FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane] (R-HSA-8853134) p-6Y-FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane] (R-HSA-8853146)	0.499	2
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.483	2
UniProt:Q7KZF4 SND1	2	SND1(1-593)-BRAF(381-766) fusion [cytosol] (R-HSA-6802469) SND1(1-593)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802552)	0.483	2
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.483	3
UniProt:O88900	1	Grb14 [cytosol] (R-RNO-204771)	0.471	3