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p-8Y-FGFR1 N546K [plasma membrane]
Stable Identifier
R-HSA-2023358
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR1 in disease (Homo sapiens)
Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants and fusions bind PLCG1 (Homo sapiens)
Activated FGFR1 mutants and fusions [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants and fusions:PLCG1 [cytosol] (Homo sapiens)
Activated FGFR1 mutants and fusions [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants and fusions phosphorylate PLCG1 (Homo sapiens)
Activated FGFR1 mutants and fusion:p-PLCG1 [cytosol] (Homo sapiens)
Activated FGFR1 mutants and fusions [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants and fusions:PLCG1 [cytosol] (Homo sapiens)
Activated FGFR1 mutants and fusions [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants bind FRS2 (Homo sapiens)
Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants phosphorylate FRS2 (Homo sapiens)
Activated FGFR1 mutants:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)
Activated FGFR1 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
Activated FGFR1 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)
Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
FGFR1 mutant receptor activation (Homo sapiens)
Signaling by activated point mutants of FGFR1 (Homo sapiens)
Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity (Homo sapiens)
Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions (Homo sapiens)
Activated FGFR1 mutants and fusion:p-PLCG1 [cytosol] (Homo sapiens)
Activated FGFR1 mutants and fusions [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants and fusions [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants [plasma membrane] (Homo sapiens)
Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
p-8Y-FGFR1 N546K [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11362 FGFR1
Gene Names
FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
Chain
signal peptide:1-21, chain:22-822
Reference Genes
BioGPS Gene:2260 FGFR1
COSMIC (genes):FGFR1 FGFR1
CTD Gene:2260 FGFR1
dbSNP Gene:2260 FGFR1
ENSEMBL:ENSG00000077782 FGFR1
ENSEMBL_homo_sapiens_GENE:ENSG00000077782.23 FGFR1
HGNC:3688 FGFR1
KEGG Gene (Homo sapiens):2260 FGFR1
Monarch:2260 FGFR1
NCBI Gene:2260 FGFR1
OMIM:136350 FGFR1
UCSC:P11362 FGFR1
Reference Transcript
RefSeq:NM_001174064.1 FGFR1
RefSeq:NM_023106.2 FGFR1
RefSeq:NM_001174067.1 FGFR1
RefSeq:NM_023110.2 FGFR1
RefSeq:NM_015850.3 FGFR1
RefSeq:NM_001174065.1 FGFR1
RefSeq:NM_001174063.1 FGFR1
RefSeq:NM_023105.2 FGFR1
RefSeq:NM_001174066.1 FGFR1
Other Identifiers
11716548_x_at
11727300_a_at
11727301_a_at
11734765_a_at
11747416_a_at
11747417_x_at
2056_at
2057_g_at
207937_PM_x_at
207937_x_at
211535_PM_s_at
211535_s_at
2260
226705_PM_at
226705_at
3132013
3132015
3132017
3132018
3132019
3132020
3132021
3132022
3132023
3132025
3132026
3132027
3132028
3132029
3132031
3132033
3132036
3132039
3132041
3132044
3132046
3132055
3132056
3132070
3132072
3132076
3132078
3132080
3132081
3132083
3132095
3132108
3132109
3132111
3132112
3132113
3132114
3132115
3132116
3493097
36168_at
424_s_at
53212_at
8150318
91005_at
A_23_P301304
A_23_P372923
A_24_P4171
GE59934
GO:0000122
GO:0000165
GO:0000166
GO:0000278
GO:0001501
GO:0001525
GO:0001657
GO:0001701
GO:0001759
GO:0001764
GO:0001837
GO:0002053
GO:0002062
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005007
GO:0005515
GO:0005524
GO:0005576
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006260
GO:0006351
GO:0006355
GO:0006468
GO:0006629
GO:0006766
GO:0007165
GO:0007169
GO:0007420
GO:0007435
GO:0007605
GO:0008201
GO:0008283
GO:0008284
GO:0008543
GO:0010463
GO:0010467
GO:0010468
GO:0010518
GO:0010629
GO:0010863
GO:0010966
GO:0010976
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0017134
GO:0018108
GO:0021769
GO:0021847
GO:0023052
GO:0030031
GO:0030154
GO:0030324
GO:0030326
GO:0030901
GO:0031175
GO:0031410
GO:0031982
GO:0035607
GO:0036211
GO:0042169
GO:0042472
GO:0042473
GO:0042474
GO:0042802
GO:0042803
GO:0043009
GO:0043226
GO:0043235
GO:0043406
GO:0043410
GO:0043536
GO:0043583
GO:0045595
GO:0045597
GO:0045666
GO:0045787
GO:0046777
GO:0048015
GO:0048339
GO:0048378
GO:0048469
GO:0048513
GO:0048514
GO:0048699
GO:0048705
GO:0048762
GO:0048856
GO:0048863
GO:0048870
GO:0050678
GO:0050877
GO:0050886
GO:0051174
GO:0051897
GO:0055065
GO:0055074
GO:0060038
GO:0060045
GO:0060089
GO:0060117
GO:0060255
GO:0060445
GO:0060484
GO:0060665
GO:0070640
GO:0071344
GO:0071529
GO:0072089
GO:0090080
GO:0090272
GO:0090722
GO:0140096
GO:1903465
GO:1904383
GO:1905564
GO:2000546
GO:2000648
GO:2000830
GO:2001239
HMNXSV003006005
HMNXSV003036243
Hs.748.8.A1_3p_at
ILMN_1729369
ILMN_1796229
ILMN_2398261
PH_hs_0000085
X66945_at
g13186246_3p_a_at
g182560_3p_a_at
Participates
as a component of
p-8Y-FGFR1 N546K dimer [plasma membrane] (Homo sapiens)
Other forms of this molecule
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
FGFR1 K656E [plasma membrane]
FGFR1 N546K [plasma membrane]
FGFR1 R576W [plasma membrane]
p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
p-8Y-FGFR1 K656E [plasma membrane]
p-8Y- FGFR1 R576W [plasma membrane]
FGFR1 [plasma membrane]
Modified Residues
Name
O4'-phospho-L-tyrosine at 766
Coordinate
766
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 463
Coordinate
463
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 583
Coordinate
583
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 585
Coordinate
585
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 653
Coordinate
653
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 654
Coordinate
654
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 730
Coordinate
730
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 776
Coordinate
776
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
L-asparagine 546 replaced with L-lysine
Coordinate
546
PsiMod
L-lysine residue [MOD:00021]
A protein modification that effectively converts a source amino acid residue to L-lysine.
L-asparagine removal [MOD:01633]
A protein modification that effectively removes or replaces an L-asparagine.
Disease
Name
Identifier
Synonyms
glioblastoma
DOID:3068
spongioblastoma multiforme, Spongioblastoma multiforme, primary glioblastoma multiforme, Glioblastoma multiforme, Glioblastoma (morphologic abnormality), GBM (Glioblastoma), Glioblastoma NOS (morphologic abnormality)
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
NP_075594.1
,
NP_075593.1
,
NP_056934.2
,
NP_001167535.1
,
NP_075598.2
,
NP_001167534.1
,
NP_001167537.1
,
NP_001167538.1
,
NP_001167536.1
ZINC - World Drugs
FGFR1_HUMAN
Guide to Pharmacology - Targets
1808
OpenTargets
ENSG00000077782
ZINC - FDA approved
FGFR1_HUMAN
ZINC - Substances
FGFR1_HUMAN
ZINC target
P11362
ZINC - Biogenic
FGFR1_HUMAN
PRO
P11362
PDB
4NKS
,
4WUN
,
8JMZ
,
4RWI
,
4V04
,
1FGK
,
3RHX
,
1FGI
,
5A4C
,
3KRJ
,
6C19
,
5UR1
,
2CR3
,
5A46
,
4V05
,
6P68
,
6C1C
,
8XLO
,
5Z0S
,
6C18
,
7OZF
,
3KRL
,
6MZQ
,
4ZSA
,
3TT0
,
5B7V
,
2FGI
,
7OZD
,
5EW8
,
1AGW
,
7WCL
,
6MZW
,
6C1O
,
3DPK
,
3JS2
,
7OZB
,
4UWB
,
3GQL
,
5AM6
,
5UQ0
,
5FLF
,
5W21
,
5O4A
,
7YSH
,
6P69
,
4F65
,
4UWY
,
1CVS
,
4UWC
,
5AM7
,
4NKA
,
4RWJ
,
4RWK
,
5O49
,
5VND
,
6C1B
,
6ITJ
,
3GQI
,
5ZV2
,
4F63
,
3OJV
,
5W59
,
1XR0
,
3KXX
,
4RWL
,
3C4F
,
4F64
,
4NK9
,
3KY2
,
1FQ9
,
6NVL
,
4V01
,
1EVT
ZINC - Investigational
FGFR1_HUMAN
IntEnz
2.7.10.1
HPA
ENSG00000077782-FGFR1
GeneCards
P11362
Ensembl
ENST00000356207
,
ENSP00000337247
,
ENSP00000380297
,
ENSP00000380280
,
ENSP00000348537
,
ENST00000397091
,
ENST00000532791
,
ENSG00000077782
,
ENST00000484370
,
ENST00000447712
,
ENSP00000400162
,
ENSP00000433163
,
ENST00000397108
,
ENST00000335922
,
ENST00000397113
,
ENSP00000380302
,
ENSP00000327229
,
ENSP00000432972
,
ENST00000326324
Pharos - Targets
P11362
Orphanet
16046
ZINC - Predictions - Purchasable
FGFR1_HUMAN
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P09038 FGF2
1
FGF2(10-155) [extracellular region]
(R-HSA-189898)
0.912
9
UniProt:P19174 PLCG1
6
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
0.903
11
UniProt:P05230 FGF1
1
FGF1 [extracellular region]
(R-HSA-189856)
0.838
5
UniProt:P46934 NEDD4
1
NEDD4 [cytosol]
(R-HSA-975992)
0.672
26
UniProt:P51812 RPS6KA3
7
RPS6KA3 [nucleoplasm]
(R-HSA-199869)
p-4S,T231,T365-RPS6KA3 [nucleoplasm]
(R-HSA-199830)
RPS6KA3 [cytosol]
(R-HSA-444250)
p-T365,S369,T577-RPS6KA3 [cytosol]
(R-HSA-9619959)
p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol]
(R-HSA-9619872)
p-T365,S369,S386,T577,T737-RPS6KA3 [cytosol]
(R-HSA-9619989)
p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm]
(R-HSA-444286)
0.671
4
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.669
3
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.644
6
UniProt:Q8IVI9 NOSTRIN
2
NOSTRIN [endocytic vesicle membrane]
(R-HSA-535014)
NOSTRIN [plasma membrane]
(R-HSA-202134)
0.633
5
UniProt:P23352 ANOS1
1
KAL1 [extracellular region]
(R-HSA-5654345)
0.626
7
UniProt:P11362 FGFR1
9
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
FGFR1 [plasma membrane]
(R-HSA-9756433)
0.623
4
UniProt:P21802 FGFR2
20
FGFR2 IIIa TM [extracellular region]
(R-HSA-8851703)
FGFR2 [plasma membrane]
(R-HSA-2023840)
FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
(R-HSA-8853137)
FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane]
(R-HSA-8853154)
FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane]
(R-HSA-8853123)
FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane]
(R-HSA-8853158)
FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane]
(R-HSA-8853150)
FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane]
(R-HSA-8853153)
FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane]
(R-HSA-8853139)
FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane]
(R-HSA-8853159)
FGFR2 N549H [plasma membrane]
(R-HSA-2033296)
FGFR2 N549K [plasma membrane]
(R-HSA-1637910)
FGFR2 K660N [plasma membrane]
(R-HSA-1637905)
FGFR2 K660M [plasma membrane]
(R-HSA-1637902)
FGFR2 K660E [plasma membrane]
(R-HSA-1637900)
FGFR2 S267P [plasma membrane]
(R-HSA-1637920)
FGFR2 L764Hfs*4 [plasma membrane]
(R-HSA-1637908)
FGFR2 W290C [plasma membrane]
(R-HSA-1637929)
p-6Y-FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
(R-HSA-8853134)
p-6Y-FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane]
(R-HSA-8853146)
0.623
3
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.623
3
UniProt:P08908 HTR1A
1
HTR1A [plasma membrane]
(R-HSA-390971)
0.62
9
UniProt:P10686 Plcg1
8
p-4Y-Plcg1 [plasma membrane]
(R-RNO-9034825)
phospho-p-Y771,Y783-PLCG1 [plasma membrane]
(R-RNO-1169084)
phospho-p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-RNO-202357)
p-Plcg1 [plasma membrane]
(R-RNO-182042)
Plcg1 [plasma membrane]
(R-RNO-182093)
PLCG1 [plasma membrane]
(R-RNO-167682)
PLCG1 [cytosol]
(R-RNO-202320)
phospho-p-4Y-PLCG1 [plasma membrane]
(R-RNO-167679)
0.611
4
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.569
4
UniProt:Q9NQH7 XPP3
0.569
3
UniProt:Q8WU20 FRS2
6
p-Y-FRS2 [cytosol]
(R-HSA-162551)
FRS2 [cytosol]
(R-HSA-190244)
p-6Y-FRS2 [cytosol]
(R-HSA-190355)
p-8T-FRS2 [plasma membrane]
(R-HSA-1270462)
FRS2 [plasma membrane]
(R-HSA-170963)
p-6Y-FRS2 [plasma membrane]
(R-HSA-170959)
0.569
3
UniProt:O35082
2
Kl [plasma membrane]
(R-MMU-190198)
Kl [extracellular region]
(R-MMU-190201)
0.558
2
UniProt:Q9GZV9 FGF23
6
p-FGF23 [endoplasmic reticulum lumen]
(R-HSA-8957077)
FGF23 [endoplasmic reticulum lumen]
(R-HSA-8956697)
FGF23(25-251) [Golgi lumen]
(R-HSA-8851630)
GalNAc-T178-FGF23(25-251) [Golgi lumen]
(R-HSA-8851624)
FGF23(25-251) [extracellular region]
(R-HSA-189891)
GalNAc-T178-FGF23(25-251) [extracellular region]
(R-HSA-8851633)
0.544
2
UniProt:P22455 FGFR4
12
FGFR4 Y367C [plasma membrane]
(R-HSA-1614439)
FGFR4 N535K [plasma membrane]
(R-HSA-1614430)
FGFR4 V550E [plasma membrane]
(R-HSA-1614433)
FGFR4 V550L [plasma membrane]
(R-HSA-1614436)
FGFR4 N535D [plasma membrane]
(R-HSA-1614427)
p-5Y-FGFR4 V550E [plasma membrane]
(R-HSA-2038932)
p-5Y-FGFR4 N535K [plasma membrane]
(R-HSA-2038931)
p-5Y-FGFR4 V550L [plasma membrane]
(R-HSA-2038935)
p-5Y-FGFR4 N535D [plasma membrane]
(R-HSA-2038934)
p5Y-FGFR4 Y367C mutant [plasma membrane]
(R-HSA-2011873)
FGFR4 [plasma membrane]
(R-HSA-189921)
p-5Y-FGFR4 [plasma membrane]
(R-HSA-190330)
0.539
3
UniProt:P12830 CDH1
8
CDH1(732-882) [plasma membrane]
(R-HSA-3827997)
CDH1(155-700) [plasma membrane]
(R-HSA-2534244)
CDH1(701-882) [extracellular region]
(R-HSA-2534158)
Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8877002)
p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8876938)
CDH1(155-750) [plasma membrane]
(R-HSA-202940)
CDH1(751-882) [plasma membrane]
(R-HSA-202929)
CDH1(155-882) [plasma membrane]
(R-HSA-198003)
0.536
3
UniProt:Q7KZF4 SND1
2
SND1(1-593)-BRAF(381-766) fusion [cytosol]
(R-HSA-6802469)
SND1(1-593)-p-BRAF(381-766) fusion [cytosol]
(R-HSA-6802552)
0.483
2
UniProt:P06493 CDK1
11
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [cytosol]
(R-HSA-170075)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
0.483
3
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.483
2
UniProt:O88900
1
Grb14 [cytosol]
(R-RNO-204771)
0.471
3
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