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About
What is Reactome ?
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License Agreement
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Disclaimer
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Table of Contents
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COVID-19 Disease Pathways
Docs
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Diseases
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Computationally inferred events
FAQ
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Citing us
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Analyse gene list
Analyse gene expression
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TTR [extracellular region]
Stable Identifier
R-HSA-976883
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Transthyretin, TTHY_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of the neuronal system (Homo sapiens)
Diseases associated with visual transduction (Homo sapiens)
Retinoid cycle disease events (Homo sapiens)
Defective STRA6 does not transport atROL (Homo sapiens)
TTR:RBP4:atROL:STRA6 mutants [plasma membrane] (Homo sapiens)
TTR:RBP4:atROL [extracellular region] (Homo sapiens)
TTR tetramer [extracellular region] (Homo sapiens)
TTR [extracellular region] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Homo sapiens)
FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
Transthyretin tetramer [extracellular region] (Homo sapiens)
TTR [extracellular region] (Homo sapiens)
HSPG2:FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
Transthyretin tetramer [extracellular region] (Homo sapiens)
TTR [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
TTR [extracellular region] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
RBP4:atROL binds TTR (Homo sapiens)
TTR tetramer [extracellular region] (Homo sapiens)
TTR [extracellular region] (Homo sapiens)
TTR:RBP4:atROL [extracellular region] (Homo sapiens)
TTR tetramer [extracellular region] (Homo sapiens)
TTR [extracellular region] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
Amyloid fibrils have additional components (Homo sapiens)
Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Systemic amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Transthyretin fibril [extracellular region] (Homo sapiens)
TTR [extracellular region] (Homo sapiens)
Amyloid fibrils [plasma membrane] (Homo sapiens)
Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Systemic amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Transthyretin fibril [extracellular region] (Homo sapiens)
TTR [extracellular region] (Homo sapiens)
Amyloid precursor proteins form ordered fibrils (Homo sapiens)
Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Systemic amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Transthyretin fibril [extracellular region] (Homo sapiens)
TTR [extracellular region] (Homo sapiens)
Amyloid fibril monomers [extracellular region] (Homo sapiens)
Systemic amyloid fibril monomers [extracellular region] (Homo sapiens)
TTR [extracellular region] (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
RBP4:atROL binds TTR (Homo sapiens)
TTR tetramer [extracellular region] (Homo sapiens)
TTR [extracellular region] (Homo sapiens)
TTR:RBP4:atROL [extracellular region] (Homo sapiens)
TTR tetramer [extracellular region] (Homo sapiens)
TTR [extracellular region] (Homo sapiens)
The canonical retinoid cycle in rods (twilight vision) (Homo sapiens)
STRA6 transports atROL from extracellular region to cytosol (Homo sapiens)
TTR:RBP4:STRA6 [plasma membrane] (Homo sapiens)
TTR tetramer [extracellular region] (Homo sapiens)
TTR [extracellular region] (Homo sapiens)
TTR:RBP4:atROL:STRA6 [plasma membrane] (Homo sapiens)
TTR:RBP4:atROL [extracellular region] (Homo sapiens)
TTR tetramer [extracellular region] (Homo sapiens)
TTR [extracellular region] (Homo sapiens)
TTR:RBP:atROL binds to STRA6 receptor (Homo sapiens)
TTR:RBP4:atROL [extracellular region] (Homo sapiens)
TTR tetramer [extracellular region] (Homo sapiens)
TTR [extracellular region] (Homo sapiens)
TTR:RBP4:atROL:STRA6 [plasma membrane] (Homo sapiens)
TTR:RBP4:atROL [extracellular region] (Homo sapiens)
TTR tetramer [extracellular region] (Homo sapiens)
TTR [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02766 TTR
Gene Names
TTR, PALB
Chain
signal peptide:1-20, chain:21-147
Reference Genes
BioGPS Gene:7276 TTR
COSMIC (genes):TTR TTR
CTD Gene:7276 TTR
dbSNP Gene:7276 TTR
ENSEMBL:ENSG00000118271 TTR
ENSEMBL:ENSG00000118271.12 TTR
HGNC:12405 TTR
KEGG Gene (Homo sapiens):7276 TTR
Monarch:7276 TTR
NCBI Gene:7276 TTR
OMIM:176300 TTR
UCSC:P02766 TTR
Reference Transcript
RefSeq:NM_000371.3 TTR
Other Identifiers
11754285_a_at
16851786
209660_PM_at
209660_at
32252_at
3783578
3783579
3783581
3783587
3783588
3783589
7276
8020795
A_23_P130333
GE80911
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005764
GO:0005773
GO:0006144
GO:0007165
GO:0023052
GO:0031410
GO:0035578
GO:0042802
GO:0043226
GO:0048018
GO:0055086
GO:0070062
GO:0070324
GO:0098772
HMNXSV003012754
M15517_cds5_at
PH_hs_0019852
PH_hs_0033292
TC18000129.hg
g5533090_3p_at
Participates
as a component of
Transthyretin tetramer [extracellular region] (Homo sapiens)
TTR tetramer [extracellular region] (Homo sapiens)
as a member of
Systemic amyloid fibril monomers [extracellular region] (Homo sapiens)
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
as a repeated unit of
Transthyretin fibril [extracellular region] (Homo sapiens)
Other forms of this molecule
TTR [azurophil granule lumen]
Inferred To
LOC112531842 [extracellular region]
(Gallus gallus)
Homologues of TTR [extracellular region]
(Caenorhabditis elegans)
Homologues of TTR [extracellular region]
(Gallus gallus)
TTR [extracellular region]
(Bos taurus)
TTR [extracellular region]
(Caenorhabditis elegans)
TTR [extracellular region]
(Canis familiaris)
TTR [extracellular region]
(Dictyostelium discoideum)
TTR [extracellular region]
(Drosophila melanogaster)
TTR [extracellular region]
(Gallus gallus)
TTR [extracellular region]
(Mus musculus)
TTR [extracellular region]
(Rattus norvegicus)
TTR [extracellular region]
(Schizosaccharomyces pombe)
TTR [extracellular region]
(Sus scrofa)
TTR [extracellular region]
(Xenopus tropicalis)
zgc:103583 [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_000362.1
ZINC - World Drugs
TTHY_HUMAN
Guide to Pharmacology - Targets
2851
OpenTargets
ENSG00000118271
ZINC - FDA approved
TTHY_HUMAN
ZINC - Substances
TTHY_HUMAN
ZINC target
P02766
ZINC - Biogenic
TTHY_HUMAN
PRO
P02766
PDB
3OZK
,
3TFB
,
5H0X
,
1DVT
,
4HJU
,
3DJT
,
5EN3
,
2WQA
,
1DVS
,
4I85
,
5K1J
,
4HJT
,
2NBO
,
2B15
,
6IMY
,
2QGD
,
5AKS
,
4FI7
,
2QGE
,
3U2J
,
7DT3
,
6XTK
,
3B56
,
1ETA
,
3NEO
,
7ERK
,
6R6I
,
5U4A
,
4TQH
,
2NOY
,
3A4F
,
3HJ0
,
1BM7
,
3P3R
,
1BZE
,
5JIM
,
5AKV
,
4WNS
,
4ABV
,
5E4O
,
6E76
,
4Y9E
,
5U4C
,
4ABU
,
4I87
,
3W3B
,
4MAS
,
5FW7
,
4PWG
,
6R66
,
3IMT
,
1Y1D
,
6D0W
,
7Q9L
,
7Q3I
,
1X7S
,
4DET
,
1FHN
,
4N86
,
4HJS
,
3DJR
,
4FI8
,
7ERH
,
1TZ8
,
4TL4
,
4N85
,
1QWH
,
3U2I
,
4TLS
,
5AKT
,
3I9A
,
1E5A
,
4IKL
,
4TNF
,
1DVY
,
7EJR
,
4FI6
,
3GLZ
,
4PWI
,
6SUG
,
5IHH
,
4Y9F
,
5CLX
,
5L4I
,
3CFT
,
3IMU
,
3A4D
,
4IKI
,
5FW8
,
1IJN
,
1TTB
,
5E23
,
6TXV
,
5H0Y
,
5LLV
,
3CN1
,
3CFN
,
5N5Q
,
2G9K
,
4DEW
,
4QYA
,
4ABQ
,
7DT5
,
3TCT
,
4DEU
,
3P3U
,
5DWP
,
5CNH
,
7ACU
,
3IMR
,
2B14
,
1BMZ
,
6FWD
,
5U48
,
3DID
,
6E71
,
1TTC
,
2B9A
,
6E74
,
4Y9B
,
3CN4
,
3NEE
,
3KGU
,
5AL0
,
5H0V
,
2G3Z
,
5AYT
,
3DO4
,
4IKJ
,
3NG5
,
4HIS
,
5JIQ
,
2G3X
,
6FXU
,
7Q9N
,
1BZ8
,
5L4J
,
7Z60
,
6R67
,
6E6Z
,
4PWF
,
1F41
,
3IMS
,
2ROX
,
6E77
,
1SOK
,
3IPB
,
4PWE
,
4TL5
,
1TSH
,
1BZD
,
4IK7
,
3P3T
,
1SOQ
,
1ZD6
,
4DES
,
3GS7
,
4PMF
,
2TRY
,
4IK6
,
4YDM
,
7W9R
,
2QGB
,
2F8I
,
5NFE
,
3GS4
,
4PVN
,
5HJG
,
2QGC
,
2TRH
,
8ADE
,
4IKK
,
4D7B
,
4PWH
,
3CFQ
,
5TTR
,
6U0Q
,
7QC5
,
3KGS
,
3CFM
,
1TYR
,
4KY2
,
4HIQ
,
2G5U
,
3KGT
,
5U4D
,
6GR7
,
2F7I
,
6SUH
,
4TM9
,
5CM1
,
2B77
,
6EOY
,
7ERI
,
5K1N
,
1DVX
,
3CXF
,
5JID
,
5EZP
,
3NEX
,
5U4F
,
6E72
,
4DER
,
4AC4
,
4PME
,
7WL6
,
4TQI
,
1ICT
,
7DT6
,
5TZL
,
4WO0
,
3DK2
,
5FW6
,
1DVQ
,
1U21
,
4TNG
,
5U4B
,
2ROY
,
5H0W
,
4ACT
,
5CR1
,
3SSG
,
5BOJ
,
2H4E
,
1ZCR
,
6TXW
,
6TI9
,
1Z7J
,
6FZL
,
3GPS
,
3D7P
,
1E4H
,
3ESP
,
1TTA
,
3CN0
,
3DGD
,
1DVU
,
4TKW
,
2FBR
,
4TLT
,
1THA
,
4TNE
,
3GS0
,
5OQ0
,
3M1O
,
4ANK
,
4PVM
,
1FH2
,
5L4F
,
1THC
,
3GRG
,
2GAB
,
3FCB
,
6SDZ
,
1ETB
,
4IIZ
,
5LLL
,
4PVL
,
5NFW
,
7OB4
,
5CLY
,
6E75
,
3CN3
,
5A6I
,
6E78
,
3CBR
,
3GRB
,
1F86
,
3ESO
,
3OZL
,
5N62
,
2NBP
,
3DK0
,
3I9P
,
6E70
,
1TLM
,
3FC8
,
5U49
,
5H0Z
,
3D2T
,
3NES
,
1E3F
,
5U4G
,
5DEJ
,
5E4A
,
4PWK
,
6R68
,
1III
,
4QXV
,
3ESN
,
6IMX
,
3I9I
,
7DT8
,
3P3S
,
4PWJ
,
1TT6
,
4Y9C
,
2QEL
,
4ABW
,
1IIK
,
4AC2
,
2M5N
,
2B16
,
4L1T
,
7ERJ
,
4QRF
,
4MRC
,
3DJZ
,
4I89
,
4L1S
,
5FO2
,
8AWI
,
4TQP
,
4MRB
,
4Y9G
,
5AL8
,
3IPE
,
6FFT
,
2G4E
,
5U4E
,
1GKO
,
4TQ8
,
3BT0
,
5L4M
,
1X7T
,
3BSZ
,
5CLZ
,
6TJN
,
5N7C
,
4N87
,
1RLB
,
4TLU
,
6GRP
,
3DJS
,
7EJQ
,
7Q9O
,
2G4G
,
4WNJ
,
6EP1
,
6KGB
,
1DVZ
,
3A4E
,
2FLM
,
7W9Q
,
1G1O
,
4YDN
,
1TTR
,
6E73
,
3IMW
,
5CN3
,
7Y1I
,
3CN2
,
3IMV
,
4TLK
,
2PAB
,
4PM1
,
1QAB
ZINC - Metabolites
TTHY_HUMAN
GeneCards
P02766
HPA
ENSG00000118271-TTR
Ensembl
ENSP00000237014
,
ENSG00000118271
,
ENST00000649620
,
ENSP00000497927
,
ENST00000237014
Pharos - Targets
P02766
ZINC - Predictions - Purchasable
TTHY_HUMAN
Orphanet
15674
HMDB Protein
HMDBP01831
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18848 ATF4
2
ATF4 [cytosol]
(R-HSA-381084)
ATF4 [nucleoplasm]
(R-HSA-381016)
0.668
3
UniProt:P02753 RBP4
3
RBP4 G75D [extracellular region]
(R-HSA-2471928)
RBP4 I41N [extracellular region]
(R-HSA-2471954)
RBP4(19-201) [extracellular region]
(R-HSA-2453675)
0.646
4
UniProt:P25713 MT3
1
MT3 [cytosol]
(R-HSA-5660396)
0.593
3
UniProt:Q15109 AGER
1
AGER [plasma membrane]
(R-HSA-197639)
0.558
2
UniProt:Q13569 TDG
3
polySUMO2,3-K330-TDG [nucleoplasm]
(R-HSA-4551628)
monoSUMO1-K330-TDG [nucleoplasm]
(R-HSA-4551718)
TDG [nucleoplasm]
(R-HSA-65812)
0.556
3
UniProt:Q8N3R9 PALS1
2
MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9689606)
MPP5 [plasma membrane]
(R-HSA-419969)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q9Y2D1 ATF5
1
ATF5 [nucleoplasm]
(R-HSA-9653719)
0.556
3
UniProt:Q8N163 CCAR2
2
DBC1 [nucleoplasm]
(R-HSA-3371479)
p-T454-DBC1 [nucleoplasm]
(R-HSA-3371569)
0.556
3
UniProt:Q06136 KDSR
1
KDSR [endoplasmic reticulum membrane]
(R-HSA-428134)
0.556
3
UniProt:Q6NXG1 ESRP1
3
ESRP1(1-606)-RAF1(227-648) fusion [cytosol]
(R-HSA-6802312)
ESRP1 [nucleoplasm]
(R-HSA-6803472)
ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol]
(R-HSA-6802523)
0.556
3
UniProt:Q8NBJ7 SUMF2
1
SUMF2 [endoplasmic reticulum lumen]
(R-HSA-1614305)
0.556
3
UniProt:Q12873 CHD3
2
CHD3 [nucleoplasm]
(R-HSA-4657012)
monoSUMO1-K1971-CHD3 [nucleoplasm]
(R-HSA-8956372)
0.553
2
UniProt:P08670 VIM
11
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.553
2
UniProt:Q15047 SETDB1
1
SETDB1 [nucleoplasm]
(R-HSA-417136)
0.553
2
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