Reactome | SETDB1 [nucleoplasm]

SETDB1 [nucleoplasm]

Stable Identifier

R-HSA-417136

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone-lysine N-methyltransferase SETDB1, SETB1_HUMAN, ESET, KMT1E

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q15047 SETDB1

Gene Names

SETDB1, ESET, KIAA0067, KMT1E

Chain

chain:1-1291

Reference Genes

BioGPS Gene:9869 SETDB1

COSMIC (genes):SETDB1 SETDB1

CTD Gene:9869 SETDB1

dbSNP Gene:9869 SETDB1

ENSEMBL:ENSG00000143379 SETDB1

ENSEMBL_homo_sapiens_GENE:ENSG00000143379.13 SETDB1

HGNC:10761 SETDB1

KEGG Gene (Homo sapiens):9869 SETDB1

Monarch:9869 SETDB1

NCBI Gene:9869 SETDB1

OMIM:604396 SETDB1

UCSC:Q15047 SETDB1

Reference Transcript

Other Identifiers

11719687_at

11757711_a_at

16670632

203155_PM_at

203155_at

214197_PM_s_at

214197_s_at

2358521

2358522

2358523

2358527

2358528

2358530

2358531

2358533

2358534

2358537

2358541

2358542

2358543

2358544

2358545

2358546

2358548

2358549

2358552

2358553

2358554

2358555

2358557

2358559

2358560

2358562

2358563

2358565

2358567

2358568

2358569

34189_at

7905258

9869

A_14_P100717

A_23_P126393

A_23_P126398

A_33_P3252479

A_33_P3305399

D31891_at

GE57172

GO:0003677

GO:0003682

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006325

GO:0008168

GO:0008270

GO:0010629

GO:0016279

GO:0016740

GO:0032259

GO:0034968

GO:0036211

GO:0042054

GO:0043226

GO:0043231

GO:0045869

GO:0046872

GO:0046974

GO:0070828

GO:0090309

GO:0140096

GO:0140938

GO:0140947

GO:0140948

GO:0140949

GO:1990841

HMNXSV003010699

HMNXSV003056740

HMNXSV003057471

Hs.20991.1.S1_3p_a_at

Hs.20991.1.S1_3p_at

ILMN_1718207

PH_hs_0023897

TC01001194.hg

TC01004737.hg

g6912651_3p_at

Participates

as a component of

as an input of

ATF7IP binds SETDB1 (Homo sapiens)

Inferred To

SETDB1 [nucleoplasm] (Bos taurus)

SETDB1 [nucleoplasm] (Canis familiaris)

SETDB1 [nucleoplasm] (Danio rerio)

SETDB1 [nucleoplasm] (Drosophila melanogaster)

SETDB1 [nucleoplasm] (Gallus gallus)

SETDB1 [nucleoplasm] (Mus musculus)

SETDB1 [nucleoplasm] (Sus scrofa)

Setdb1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_016858444.1, NP_001138887.1, NP_036564.3, NP_001230420.1

ZINC - World Drugs

SETB1_HUMAN

Guide to Pharmacology - Targets

2705

OpenTargets

ENSG00000143379

ZINC - Substances

SETB1_HUMAN

ZINC - Biogenic

SETB1_HUMAN

ZINC target

Q15047

PRO

Q15047

PDB

6BHH, 5KH6, 6AU3, 6BHD, 4X3S, 5QT2, 6BHI, 5KCH, 8IYA, 7C9N, 7CAJ, 6BPI, 8UWP, 5KCO, 8G5E, 7CD9, 6AU2, 6BHG, 7CJT, 3DLM, 5QT1, 5KE3, 6BHE, 5KE2

ZINC - Metabolites

SETB1_HUMAN

IntEnz

2.1.1.366

HPA

ENSG00000143379-SETDB1

GeneCards

Q15047

Ensembl

ENSP00000271640, ENSG00000143379, ENST00000368969, ENSP00000357965, ENSP00000357958, ENST00000368962, ENST00000271640

Pharos - Targets

Q15047

ZINC - Predictions - Purchasable

SETB1_HUMAN

HMDB Protein

HMDBP00411

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.639	9
UniProt:Q9Y6K1 DNMT3A	2	monoSUMO1-K-DNMT3A [nucleoplasm] (R-HSA-4655415) DNMT3A [nucleoplasm] (R-HSA-212287)	0.61	7
UniProt:Q9UIS9 MBD1	2	monoSUMO1-K499,K538-MBD1 [nucleoplasm] (R-HSA-4090331) MBD1 [nucleoplasm] (R-HSA-417134)	0.581	3
UniProt:Q99549 MPHOSPH8	1	MPHOSPH8 [nucleoplasm] (R-HSA-9844052)	0.564	3
UniProt:P04183 TK1	1	TK1 [cytosol] (R-HSA-73500)	0.553	2
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481)	0.553	2
UniProt:P11802 CDK4	3	CDK4 [cytosol] (R-HSA-68330) CDK4 [nucleoplasm] (R-HSA-113843) p-T172-CDK4 [nucleoplasm] (R-HSA-113830)	0.553	2
UniProt:Q9H9J2 MRPL44	1	MRPL44 [mitochondrial inner membrane] (R-HSA-5368245)	0.553	2
UniProt:Q15714 T22D1			0.553	2
UniProt:P61956 SUMO2	6	lysyl-G93-SUMO2 [cytosol] (R-HSA-9834803) SUMO2(1-95) [nucleoplasm] (R-HSA-2990837) UBA2-G93-SUMO2 [nucleoplasm] (R-HSA-3730618) SUMO2 [nucleoplasm] (R-HSA-2984281) UBE2I-G93-SUMO2 [nucleoplasm] (R-HSA-3730625) lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm] (R-HSA-9761546)	0.553	2
UniProt:P02766 TTR	2	TTR [azurophil granule lumen] (R-HSA-6799366) TTR [extracellular region] (R-HSA-976883)	0.553	2
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	5
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.527	2
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.524	3
UniProt:Q9NWR8 MCUB	1	MCUB [mitochondrial inner membrane] (R-HSA-8949153)	0.499	3

Cite Us!