Reactome | monoSUMO1-K330-TDG [nucleoplasm]

monoSUMO1-K330-TDG [nucleoplasm]

Stable Identifier

R-HSA-4551718

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.-)

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13569 TDG

Gene Names

TDG

Chain

chain:1-410

Reference Genes

BioGPS Gene:6996 TDG

COSMIC (genes):TDG TDG

CTD Gene:6996 TDG

dbSNP Gene:6996 TDG

ENSEMBL:ENSG00000139372 TDG

HGNC:11700 TDG

Monarch:6996 TDG

NCBI Gene:6996 TDG

OMIM:601423 TDG

UCSC:Q13569 TDG

Reference Transcript

RefSeq:NM_003211.4 TDG

Other Identifiers

11746509_a_at

11758036_s_at

11761192_a_at

16756111

203742_PM_s_at

203743_PM_s_at

203743_s_at

3373603

3408686

3408687

3408690

3408691

3408693

3408694

3408697

3429366

3429367

3429369

3429372

3429373

3429374

3429375

3429377

3429378

3429379

3429380

3429381

3429383

3429384

3429385

3429386

3429387

40865_at

6996

7958147

A_14_P110025

A_14_P129081

A_14_P138419

A_23_P204579

A_24_P526177

A_33_P3357445

GE81245

GO:0000122

GO:0000287

GO:0000700

GO:0003676

GO:0003677

GO:0003684

GO:0003690

GO:0003712

GO:0003824

GO:0004844

GO:0005080

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005886

GO:0006281

GO:0006284

GO:0006285

GO:0006325

GO:0006355

GO:0008263

GO:0016605

GO:0016787

GO:0019104

GO:0019904

GO:0030983

GO:0031402

GO:0031404

GO:0032183

GO:0040029

GO:0043226

GO:0043739

GO:0045008

GO:0045995

GO:0055086

GO:0060090

GO:0140097

GO:0140110

GO:0140297

GO:0141016

GO:0141167

GO:1901135

HMNXSV003003285

HMNXSV003007708

ILMN_1777096

ILMN_1782331

PH_hs_0030709

TC12000254.hg

TC12000804.hg

TC12002547.hg

U51166_at

g4507422_3p_a_at

Participates

as an output of

SUMOylation of TDG with SUMO1 (Homo sapiens)

Other forms of this molecule

TDG [nucleoplasm]

polySUMO2,3-K330-TDG [nucleoplasm]

Inferred To

monoSUMO1-K330-TDG [nucleoplasm] (Gallus gallus)

TDG [nucleoplasm] (Bos taurus)

TDG [nucleoplasm] (Sus scrofa)

tdg [nucleoplasm] (Xenopus tropicalis)

thp1 [nucleoplasm] (Schizosaccharomyces pombe)

tdg.1 [nucleoplasm] (Danio rerio)

Tdg [nucleoplasm] (Mus musculus)

Tdg [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 330

Coordinate

330

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

OpenTargets

ENSG00000139372

ENSEMBL

ENST00000392872, ENSP00000376611

IntEnz

3.2.2.29

HPA

ENSG00000139372-TDG

PRO

Q13569

Pharos - Targets

Q13569

HMDB Protein

HMDBP09192

PDB

1WYW, 5CYS, 4Z7Z, 4Z47, 6U15, 5HF7, 4Z7B, 6U17, 4JGC, 3UO7, 5T2W, 4Z3A, 6U16, 4XEG, 3UFJ, 3UOB, 4FNC, 5JXY, 2RBA, 2D07, 5FF8

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.667	3
UniProt:Q15788 NCOA1	3	NCOA1 [nucleoplasm] (R-HSA-442496) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291)	0.576	8
UniProt:Q9GZX7 AICDA	1	AICDA [nucleoplasm] (R-HSA-452477)	0.576	5
UniProt:P61956 SUMO2	6	lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm] (R-HSA-9761546) UBE2I-G93-SUMO2 [nucleoplasm] (R-HSA-3730625) SUMO2 [nucleoplasm] (R-HSA-2984281) lysyl-G93-SUMO2 [cytosol] (R-HSA-9834803) UBA2-G93-SUMO2 [nucleoplasm] (R-HSA-3730618) SUMO2(1-95) [nucleoplasm] (R-HSA-2990837)	0.558	2
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P02766 TTR	2	TTR [azurophil granule lumen] (R-HSA-6799366) TTR [extracellular region] (R-HSA-976883)	0.556	3
UniProt:Q92870-2 Q928702			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:A0A6Q8PF08 A0A6Q8PF08			0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.556	3
UniProt:P60891 PRPS1	1	PRPS1 [cytosol] (R-HSA-73483)	0.556	3
UniProt:P24522 GADD45A	1	GADD45A [nucleoplasm] (R-HSA-3215139)	0.524	3
UniProt:O88846	1	RNF4 [cytosol] (R-RNO-975974)	0.499	2
UniProt:PGR ENSG00000082175			0.499	2

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