polySUMO2,3-K330-TDG [nucleoplasm]

Stable Identifier
R-HSA-4551628
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.-)
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
11889051 Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover

Hardeland, U, Steinacher, R, Jiricny, J, Schär, P

EMBO J. 2002
24782567 Proteome-wide identification of SUMO2 modification sites

Tammsalu, T, Matic, I, Jaffray, EG, Ibrahim, AF, Tatham, MH, Hay, RT

Sci Signal 2014
16626738 Crystal structure of SUMO-3-modified thymine-DNA glycosylase

Baba, D, Maita, N, Jee, JG, Uchimura, Y, Saitoh, H, Sugasawa, K, Hanaoka, F, Tochio, H, Hiroaki, H, Shirakawa, M

J. Mol. Biol. 2006
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC

Nat. Struct. Mol. Biol. 2014
External Reference Information
External Reference
UniProt:Q13569 TDG
Gene Names
TDG
Chain
chain:1-410
Reference Genes
BioGPS Gene:6996 TDG
COSMIC (genes):TDG TDG
CTD Gene:6996 TDG
dbSNP Gene:6996 TDG
ENSEMBL:ENSG00000139372 TDG
HGNC:11700 TDG
KEGG:hsa:6996 TDG
Monarch:6996 TDG
NCBI Gene:6996 TDG
OMIM:601423 TDG
UCSC:Q13569 TDG
Reference Transcript
Other Identifiers
11746509_a_at
11758036_s_at
11761192_a_at
16756111
203742_PM_s_at
203743_PM_s_at
203743_s_at
3373603
3408686
3408687
3408690
3408691
3408693
3408694
3408697
3429366
3429367
3429369
3429372
3429373
3429374
3429375
3429377
3429378
3429379
3429380
3429381
3429383
3429384
3429385
3429386
3429387
40865_at
6996
7958147
A_14_P110025
A_14_P129081
A_14_P138419
A_23_P204579
A_24_P526177
A_33_P3357445
GE81245
GO:0000122
GO:0000287
GO:0000700
GO:0003676
GO:0003677
GO:0003684
GO:0003690
GO:0003712
GO:0003824
GO:0004844
GO:0005080
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005886
GO:0006281
GO:0006284
GO:0006285
GO:0006325
GO:0006355
GO:0006974
GO:0008263
GO:0016605
GO:0016787
GO:0019104
GO:0019904
GO:0030983
GO:0031402
GO:0031404
GO:0032183
GO:0040029
GO:0043739
GO:0045008
GO:0045995
GO:0055086
GO:0140097
GO:0140297
GO:0141016
GO:0141167
GO:1901135
HMNXSV003003285
HMNXSV003007708
ILMN_1777096
ILMN_1782331
PH_hs_0030709
TC12000254.hg
TC12000804.hg
TC12002547.hg
U51166_at
g4507422_3p_a_at
Participates
as an output of
Other forms of this molecule
TDG [nucleoplasm]
monoSUMO1-K330-TDG [nucleoplasm]
Inferred To
tdg.2 [nucleoplasm] (Danio rerio)
TDG [nucleoplasm] (Bos taurus)
TDG [nucleoplasm] (Sus scrofa)
tdg [nucleoplasm] (Xenopus tropicalis)
5-MCDG [nucleoplasm] (Gallus gallus)
Tdg [nucleoplasm] (Drosophila melanogaster)
Tdg [nucleoplasm] (Mus musculus)
Tdg [nucleoplasm] (Rattus norvegicus)
Modified Residues
Name
sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 330
Coordinate
330
Modification
polySUMO2,3 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
OpenTargets
ENSEMBL
IntEnz
HPA
GeneCards
TDG
PRO
Pharos - Targets
HMDB Protein
PDB
Interactors (19)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P63165 SUMO1  11 0.667 3
 UniProt:Q9GZX7 AICDA  1 0.576 5
 UniProt:Q15788 NCOA1  3 0.576 8
 UniProt:P61956 SUMO2  6 0.558 2
 UniProt:P02766 TTR  2 0.556 3
 UniProt:Q92870-2 Q928702      0.556 3
 IntAct:EBI-25847655 CCSB      0.556 3
 UniProt:O60333-2 KIF1B      0.556 3
 UniProt:P28799 GRN  2 0.556 3
 UniProt:A0A6Q8PF08 A0A6Q8PF08      0.556 3
 UniProt:Q9Y3C5 RNF11      0.556 3
 UniProt:P04792 HSPB1  3 0.556 3
 UniProt:P07196 NEFL  1 0.556 3
 UniProt:P60891 PRPS1  1 0.556 3
 UniProt:O76024 WFS1  3 0.556 3
 UniProt:P37840 SNCA  5 0.556 3
 UniProt:P24522 GADD45A  1 0.524 3
 UniProt:O88846  1 0.499 2
 UniProt:PGR ENSG00000082175      0.499 2
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