polySUMO2,3-K330-TDG [nucleoplasm]

Stable Identifier
R-HSA-4551628
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.-)
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
11889051 Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover

Steinacher, R, Hardeland, U, Schär, P, Jiricny, J

EMBO J. 2002
24782567 Proteome-wide identification of SUMO2 modification sites

Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I

Sci Signal 2014
16626738 Crystal structure of SUMO-3-modified thymine-DNA glycosylase

Shirakawa, M, Baba, D, Hiroaki, H, Maita, N, Tochio, H, Uchimura, Y, Sugasawa, K, Hanaoka, F, Saitoh, H, Jee, JG

J. Mol. Biol. 2006
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M

Nat. Struct. Mol. Biol. 2014
External Reference Information
External Reference
UniProt:Q13569 TDG
Gene Names
TDG
Chain
chain:1-410
Reference Genes
BioGPS Gene:6996 TDG
COSMIC (genes):TDG TDG
CTD Gene:6996 TDG
dbSNP Gene:6996 TDG
ENSEMBL:ENSG00000139372 TDG
HGNC:11700 TDG
Monarch:6996 TDG
NCBI Gene:6996 TDG
OMIM:601423 TDG
UCSC:Q13569 TDG
Reference Transcript
Other Identifiers
11746509_a_at
11758036_s_at
11761192_a_at
16756111
203742_PM_s_at
203743_PM_s_at
203743_s_at
3373603
3408686
3408687
3408690
3408691
3408693
3408694
3408697
3429366
3429367
3429369
3429372
3429373
3429374
3429375
3429377
3429378
3429379
3429380
3429381
3429383
3429384
3429385
3429386
3429387
40865_at
6996
7958147
A_14_P110025
A_14_P129081
A_14_P138419
A_23_P204579
A_24_P526177
A_33_P3357445
GE81245
GO:0000122
GO:0000287
GO:0000700
GO:0003676
GO:0003677
GO:0003684
GO:0003690
GO:0003712
GO:0003824
GO:0004844
GO:0005080
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005886
GO:0006281
GO:0006284
GO:0006285
GO:0006325
GO:0006355
GO:0008263
GO:0016605
GO:0016787
GO:0019104
GO:0019904
GO:0030983
GO:0031402
GO:0031404
GO:0032183
GO:0040029
GO:0043226
GO:0043739
GO:0045008
GO:0045995
GO:0055086
GO:0060090
GO:0140097
GO:0140110
GO:0140297
GO:0141016
GO:0141167
GO:1901135
HMNXSV003003285
HMNXSV003007708
ILMN_1777096
ILMN_1782331
PH_hs_0030709
TC12000254.hg
TC12000804.hg
TC12002547.hg
U51166_at
g4507422_3p_a_at
Participates
as an output of
Other forms of this molecule
TDG [nucleoplasm]
monoSUMO1-K330-TDG [nucleoplasm]
Inferred To
polySUMO2,3-K330-TDG [nucleoplasm] (Gallus gallus)
TDG [nucleoplasm] (Bos taurus)
TDG [nucleoplasm] (Sus scrofa)
tdg [nucleoplasm] (Xenopus tropicalis)
tdg.1 [nucleoplasm] (Danio rerio)
Tdg [nucleoplasm] (Drosophila melanogaster)
Tdg [nucleoplasm] (Mus musculus)
Tdg [nucleoplasm] (Rattus norvegicus)
Modified Residues
Name
sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 330
Coordinate
330
Modification
polySUMO2,3 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
OpenTargets
ENSEMBL
IntEnz
HPA
PRO
Pharos - Targets
HMDB Protein
PDB
Interactors (19)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P63165 SUMO1  11 0.667 3
 UniProt:Q15788 NCOA1  3 0.576 8
 UniProt:Q9GZX7 AICDA  1 0.576 5
 UniProt:P61956 SUMO2  6 0.558 2
 UniProt:P37840 SNCA  5 0.556 3
 UniProt:P04792 HSBP1  3 0.556 3
 UniProt:O76024 WFS1  3 0.556 3
 UniProt:P02766 TTR  2 0.556 3
 UniProt:Q92870-2 Q928702      0.556 3
 IntAct:EBI-25847655 CCSB      0.556 3
 UniProt:O60333-2 KIF1B      0.556 3
 UniProt:P28799 GRN  2 0.556 3
 UniProt:A0A6Q8PF08 A0A6Q8PF08      0.556 3
 UniProt:Q9Y3C5 RNF11      0.556 3
 UniProt:P07196 NEFL  1 0.556 3
 UniProt:P60891 PRPS1  1 0.556 3
 UniProt:P24522 GADD45A  1 0.524 3
 UniProt:O88846  1 0.499 2
 UniProt:PGR ENSG00000082175      0.499 2
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