p-S2,S5-POLR2A [nucleoplasm]

Stable Identifier
R-HSA-113420
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
RNA Pol II (Ser2,5 phosphorylated) largest subunit, DNA-directed RNA polymerase II largest subunit , RPB1
Locations in the PathwayBrowser
General

The C-terminal domain (CTD) of POLR2A contains about 52 repeats of the consensus heptad YSPTSPS. Serines-2 and 5 of the heptads are phosphorylated in RNA polymerase II initiating transcription of protein coding genes. The exact repeats that are phosphorylated are not known.

Literature References
PubMed ID Title Journal Year
16012166 Evidence that phosphorylation of the RNA polymerase II carboxyl-terminal repeats is similar in yeast and humans

Morris, DP, Michelotti, GA, Schwinn, DA

J. Biol. Chem. 2005
Participates
Other forms of this molecule
Inferred To
Modified Residues
Name
O-phospho-L-serine at 5
Coordinate
5
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 2
Coordinate
2
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
OpenTargets
GeneCards
PRO
HMDB Protein
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