Reactome | NCBP2 [cytosol]

NCBP2 [cytosol]

Stable Identifier

R-HSA-162458

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CBP20, 20 kDa nuclear cap binding protein (NCBP 20 kDa subunit) (CBP20) (NCBP interacting protein 1) (NIP1), 20 kDa nuclear cap binding protein, NCBP 20 kDa subunit, NCBP interacting protein 1, NIP1

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Regulation of expression of SLITs and ROBOs (Homo sapiens)
        
        Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP2 [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        ROBO3.2 mRNA:CBC:EIF4G1:PABPC1 [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP2 [cytosol] (Homo sapiens)
        
        Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        ROBO3.2 mRNA:CBC:EIF4G1:PABPC1 [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP2 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Metabolism of non-coding RNA (Homo sapiens)
  - snRNP Assembly (Homo sapiens)
    - Nuclear export of snRNA transcripts (Homo sapiens)
      - Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP2 [cytosol] (Homo sapiens)
- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)
      - Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP2 [cytosol] (Homo sapiens)
      - mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP2 [cytosol] (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP2 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP2 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP2 [cytosol] (Homo sapiens)
      - mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP2 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP2 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP2 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP2 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP2 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP2 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP2 [cytosol] (Homo sapiens)
- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - Transport of Mature Transcript to Cytoplasm (Homo sapiens)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
      - Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP2 [cytosol] (Homo sapiens)
      - mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP2 [cytosol] (Homo sapiens)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Homo sapiens)
        
        Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
        
        NCBP2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P52298 NCBP2

Gene Names

NCBP2, CBP20, PIG55

Chain

initiator methionine:, chain:2-156

Reference Genes

BioGPS Gene:22916 NCBP2

COSMIC (genes):NCBP2 NCBP2

CTD Gene:22916 NCBP2

dbSNP Gene:22916 NCBP2

ENSEMBL:ENSG00000114503 NCBP2

HGNC:7659 NCBP2

KEGG:hsa:22916 NCBP2

Monarch:22916 NCBP2

NCBI Gene:22916 NCBP2

OMIM:605133 NCBP2

UCSC:P52298 NCBP2

Reference Transcript

Participates

as a component of

Cap Binding Complex (CBC) [cytosol] (Homo sapiens)

Other forms of this molecule

NCBP2 [nucleoplasm]

Inferred To

NCBP2 [cytosol] (Bos taurus)

NCBP2 [cytosol] (Caenorhabditis elegans)

NCBP2 [cytosol] (Canis familiaris)

NCBP2 [cytosol] (Danio rerio)

NCBP2 [cytosol] (Dictyostelium discoideum)

NCBP2 [cytosol] (Drosophila melanogaster)

NCBP2 [cytosol] (Gallus gallus)

NCBP2 [cytosol] (Mus musculus)

NCBP2 [cytosol] (Plasmodium falciparum)

NCBP2 [cytosol] (Rattus norvegicus)

NCBP2 [cytosol] (Saccharomyces cerevisiae)

NCBP2 [cytosol] (Schizosaccharomyces pombe)

NCBP2 [cytosol] (Sus scrofa)

NCBP2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001036005.1, NP_031388.2, NP_001294965.1

OpenTargets

ENSG00000114503

ENSEMBL

ENSG00000114503, ENSP00000326806, ENST00000321256, ENSP00000397619, ENST00000452404, ENSP00000412785, ENST00000427641

HPA

ENSG00000114503-NCBP2

GeneCards

NCBP2

PRO

P52298

Pharos - Targets

P52298

GlyGen

P52298

PDB

5OOB, 8PMP, 8SRR, 6D0Y, 8PNT, 5OO6, 8SUY, 7ABG, 1H2T, 1N52, 1N54, 1H2V, 1H2U, 3FEY, 3FEX, 8BY6, 1H6K

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.965	54
UniProt:Q9H814 PHAX	2	PHAX [cytosol] (R-HSA-191804) PHAX [nucleoplasm] (R-HSA-191803)	0.725	10
ChEBI:50210 7-METHYL-GTP			0.688	13
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.643	6
UniProt:Q9BXP5 SRRT	1	SRRT [nucleoplasm] (R-HSA-6814858)	0.643	8
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.643	3
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.643	9
UniProt:P18615 NELFE	2	NELFE [nucleoplasm] (R-HSA-62907) p-NELFE [nucleoplasm] (R-HSA-170698)	0.643	4
UniProt:Q6NZY4 ZCCHC8	1	ZCCHC8 [nucleoplasm] (R-HSA-8985573)	0.643	3
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.643	6
UniProt:Q9Y5S9 RBM8A	2	RBM8A [nucleoplasm] (R-HSA-156659) RBM8A [cytosol] (R-HSA-162462)	0.643	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:P42285 SKIV2L2	2	SKIV2L2 [nucleoplasm] (R-HSA-6791189) MTREX [nucleolus] (R-HSA-9935826)	0.527	4
UniProt:O60684 KPNA6	2	KPNA6 [nucleoplasm] (R-HSA-9734665) KPNA6 [cytosol] (R-HSA-9734672)	0.527	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.527	2
UniProt:Q53F19 NCBP3			0.527	4
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.527	2
UniProt:Q9Y580 RBM7	1	RBM7 [nucleoplasm] (R-HSA-8985564)	0.527	2
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.527	2
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.527	3
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.527	5
UniProt:Q8WX92 NELFB	3	NELFB [cytosol] (R-HSA-9603526) NELFB [mitochondrial outer membrane] (R-HSA-9603553) NELFB [nucleoplasm] (R-HSA-112427)	0.527	3
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.527	2
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.483	2
UniProt:Q9NWB6 ARGL1			0.483	2