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PPP3CA [nucleoplasm]
Stable Identifier
R-HSA-2685599
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform, P2BA_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A (Dectin-1) induces NFAT activation (Homo sapiens)
Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
NFAT:CaN:CaM [nucleoplasm] (Homo sapiens)
CaN:CaM:Ca2+ [nucleoplasm] (Homo sapiens)
CaN catalytic alpha/beta:Zn++:Fe3+:CaM:Ca2+ [nucleoplasm] (Homo sapiens)
CaN catalytic alpha/beta:Zn++:Fe3+ [nucleoplasm] (Homo sapiens)
CaN-catalytic alpha/beta chains [nucleoplasm] (Homo sapiens)
PPP3CA [nucleoplasm] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
NFAT:CaN:CaM [nucleoplasm] (Homo sapiens)
CaN:CaM:Ca2+ [nucleoplasm] (Homo sapiens)
CaN catalytic alpha/beta:Zn++:Fe3+:CaM:Ca2+ [nucleoplasm] (Homo sapiens)
CaN catalytic alpha/beta:Zn++:Fe3+ [nucleoplasm] (Homo sapiens)
CaN-catalytic alpha/beta chains [nucleoplasm] (Homo sapiens)
PPP3CA [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
Translocation of NFATC1:CaN:CaM to nucleus (Homo sapiens)
NFATC1:CaN:CaM [nucleoplasm] (Homo sapiens)
CaN:CaM:Ca2+ [nucleoplasm] (Homo sapiens)
CaN catalytic alpha/beta:Zn++:Fe3+:CaM:Ca2+ [nucleoplasm] (Homo sapiens)
CaN catalytic alpha/beta:Zn++:Fe3+ [nucleoplasm] (Homo sapiens)
CaN-catalytic alpha/beta chains [nucleoplasm] (Homo sapiens)
PPP3CA [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q08209 PPP3CA
Gene Names
PPP3CA, CALNA, CNA
Chain
initiator methionine:, chain:2-521
Reference Genes
COSMIC (genes):PPP3CA PPP3CA
dbSNP Gene:5530 PPP3CA
ENSEMBL:ENSG00000138814 PPP3CA
Participates
as a member of
CaN-catalytic alpha/beta chains [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PPP3CA [cytosol]
Inferred To
PPP3CA [nucleoplasm]
(Bos taurus)
PPP3CA [nucleoplasm]
(Caenorhabditis elegans)
PPP3CA [nucleoplasm]
(Canis familiaris)
PPP3CA [nucleoplasm]
(Dictyostelium discoideum)
PPP3CA [nucleoplasm]
(Drosophila melanogaster)
PPP3CA [nucleoplasm]
(Gallus gallus)
PPP3CA [nucleoplasm]
(Mus musculus)
PPP3CA [nucleoplasm]
(Plasmodium falciparum)
PPP3CA [nucleoplasm]
(Rattus norvegicus)
PPP3CA [nucleoplasm]
(Schizosaccharomyces pombe)
PPP3CA [nucleoplasm]
(Sus scrofa)
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.678
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
10
UniProt:P49841 GSK3B
4
GSK3B [cytosol]
(R-HSA-2997551)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [nucleoplasm]
(R-HSA-2022823)
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
0.483
2
UniProt:P54578 USP14
1
USP14 [cytosol]
(R-HSA-5689541)
0.463
3
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