Reactome | CASK [cytosol]

CASK [cytosol]

Stable Identifier

R-HSA-373631

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Peripheral plasma membrane protein CASK

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External Reference Information

External Reference

UniProt:O14936 CASK

Gene Names

CASK, LIN2

Chain

chain:1-926

Reference Genes

BioGPS Gene:8573 CASK

COSMIC (genes):CASK CASK

CTD Gene:8573 CASK

dbSNP Gene:8573 CASK

ENSEMBL:ENSG00000147044 CASK

HGNC:1497 CASK

KEGG Gene (Homo sapiens):8573 CASK

Monarch:8573 CASK

NCBI Gene:8573 CASK

OMIM:300172 CASK

UCSC:O14936 CASK

Reference Transcript

Other Identifiers

0001660504

11721586_a_at

11729379_s_at

11729380_a_at

11758271_s_at

17110237

207620_s_at

211208_s_at

227156_at

238699_s_at

31854_at

36414_s_at

4005868

4005869

4005870

4005871

4005872

4005873

4005874

4005875

4005876

4005877

4005882

4005885

4005886

4005887

4005888

4005891

4005892

4005893

4005897

4005898

4005899

4005902

4005903

4005904

4005908

4005910

4005915

4005919

4005921

4005924

4005933

4005936

4005948

4005956

4005969

4005970

4005971

4005972

4005973

4005974

61707_at

8172158

8573

88441_g_at

A_24_P288722

A_32_P168464

GE54283

GE87345

GO:0000166

GO:0001953

GO:0003674

GO:0004385

GO:0004672

GO:0004674

GO:0005515

GO:0005516

GO:0005524

GO:0005575

GO:0005576

GO:0005604

GO:0005622

GO:0005634

GO:0005652

GO:0005730

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005911

GO:0005925

GO:0005929

GO:0006464

GO:0006468

GO:0006810

GO:0006950

GO:0007155

GO:0007267

GO:0007269

GO:0008150

GO:0008283

GO:0010839

GO:0015629

GO:0016020

GO:0016301

GO:0016310

GO:0016363

GO:0016740

GO:0031012

GO:0034641

GO:0042734

GO:0043167

GO:0043226

GO:0044281

GO:0046037

GO:0046710

GO:0060170

GO:0061045

GO:0090288

GO:0106310

GO:0106311

HMNXSV003022794

Hs.3327.0.S1_3p_at

ILMN_1654773

PH_hs_0000403

PH_hs_0023503

TC0X000969.hg

TC0X002040.hg

g13359270_3p_a_at

g4502566_3p_a_at

Participates

as a component of

as an input of

Inferred To

caska [cytosol] (Danio rerio)

lin-2 [cytosol] (Caenorhabditis elegans)

CASK [cytosol] (Bos taurus)

CASK [cytosol] (Canis familiaris)

CASK [cytosol] (Drosophila melanogaster)

CASK [cytosol] (Gallus gallus)

CASK [cytosol] (Sus scrofa)

Cask [cytosol] (Mus musculus)

Cask [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001119526.1, NP_001119527.1, NP_003679.2

ZINC - World Drugs

CSKP_HUMAN

OpenTargets

ENSG00000147044

ZINC - FDA approved

CSKP_HUMAN

ZINC - Substances

CSKP_HUMAN

ZINC - Biogenic

CSKP_HUMAN

ZINC target

O14936

PRO

O14936

PDB

3TAC, 3C0I, 3MFU, 6KMH, 3MFT, 1ZL8, 3C0H, 3MFR, 1KGD, 1KWA, 3MFS, 3C0G

ZINC - Investigational

CSKP_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000147044-CASK

GeneCards

O14936

Ensembl

ENSG00000147044, ENSP00000494788, ENST00000378154, ENST00000378163, ENSP00000494183, ENST00000644347, ENSP00000400526, ENSP00000367396, ENSP00000367405, ENST00000645566, ENST00000421587

ZINC - Predictions - Purchasable

CSKP_HUMAN

Orphanet

17592

HMDB Protein

HMDBP08709

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14910 LIN7A	2	LIN7A [transport vesicle membrane] (R-HSA-9610413) LIN7A [plasma membrane] (R-HSA-5216076)	0.775	6
UniProt:Q9H788 SH24A			0.666	4
UniProt:Q8WXD9 CSKI1			0.639	4
UniProt:Q63373 NRX1B			0.582	3
UniProt:Q9Y2J0 RP3A			0.581	3
UniProt:Q8VHK2 CSKI1			0.544	2
UniProt:P34741 SDC2	28	SDC2 [plasma membrane] (R-HSA-2090052) p-Y179,Y191-SDC2 [plasma membrane] (R-HSA-4093306) SDC2 [lysosomal lumen] (R-HSA-2090083) HS(6)-SDC2 [lysosomal lumen] (R-HSA-2090064) HS(6)-SDC2 [Golgi lumen] (R-HSA-2076588) HS(5)-SDC2 [Golgi lumen] (R-HSA-2076320) Heparan-SDC2 [Golgi lumen] (R-HSA-2076608) Heparan(1)-SDC2 [Golgi lumen] (R-HSA-2076536) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) SDC2 [Golgi lumen] (R-HSA-2054101) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443)	0.527	2
UniProt:Q12929 EPS8	1	EPS8 [cytosol] (R-HSA-9662382)	0.524	3
UniProt:P41134 ID1	1	ID1 [nucleoplasm] (R-HSA-2534101)	0.508	3